The Godfather of Surgery

Li Ruizhong called his wife at home and asked about the study status of his two children. He lied to his wife and said that it was nothing serious, just ordinary arthritis and that he would need to stay in the hospital for a few days for treatment.

His wife told him to cure his illness and not to worry about his family.

Li Ruizhong works in a science and technology park. There are many companies in this science and technology park. He has worked in a factory there for more than ten years and is also an old employee. His two children attend private schools nearby, a primary school and a kindergarten.

In order to supplement his family income, he rented a small shop next to the park. His wife usually works at the shop and sells mineral water, ice cream, milk, drinks and snacks. He also uses the shop as a courier collection station. Although the income is not high, it can subsidize some living expenses. In short He also works outside the home and tries his best to expand his income, so the whole family needs money.

When this kind of thing happened, Li Ruizhong could only carry it silently. He had no choice but to call himself the backbone of the family. Fortunately, he met a good doctor, and Professor Zhang became his spiritual support for treating diseases.

Yang Ping read Li Ruizhong's medical records. In fact, Li Ruizhong's condition is still very serious. The effect of chemotherapy may not be good. Cell therapy is the best choice. Unfortunately, for an ordinary migrant worker, it is difficult to take out a One million and two hundred thousand is simply impossible.

How? Song Zimo asked.

For surgeons who perform operations every day, it is a bit uncomfortable to suddenly receive patients who need medical treatment.

In fact, medicine and surgery are all means, and the purpose is to eliminate the pain of disease and restore patients to health.

Diffuse large B-cell lymphoma requires either chemotherapy, radiotherapy, or CAR-T cells. Other treatments are of little use.

''If - the economic conditions - are good, just give him - CAR-T cell therapy - that's it. I guess one shot can solve the problem. Xu Zhiliang couldn't help but feel a little pity.

Song Zimo felt that the CAR-T cells mentioned by Xu Zhiliang were not realistic at all: Chemotherapy, rituximab + CHOP regimen.

Everyone discussed and discussed, looking at Yang Ping.

Yang Ping thought for a moment and said, Give him cell therapy.

Surgical research has its own characteristics, and we should try our best to give full play to our own research characteristics, rather than simply providing patients with routine treatment.

It's 1.2 million, plus other expenses, it's almost two million.

Song Zimo reminded Yang Ping that this was an ordinary migrant worker, how could he afford such expensive treatment.

Yang Ping nodded, indicating that he knew the situation, and then said: Our own stem cell laboratory can operate and perform cell therapy without using current patented technology. Our own laboratory can collect, purify and amplify T lymphocytes. Let the genetics laboratory of Nandu Medical University do the cell modification, and it won’t cost much.”

Not using patented technology? Bypassing them?

Song Zimo was a little confused. It was impossible to bypass other people's patents.

Yes, go around it! Yang Ping was very sure.

Everyone was very surprised. This shows that Professor Yang has his own method, which is different from the current mainstream cell therapy in the world. Professor Yang always catches people by surprise.

In fact, these cell therapies are all by-products of Yang Ping's experiments in the system space. Because of a large number of experiments and a lot of trial and error, although those trial and error experiments did not achieve the experimental goals, they obtained some unexpected new things. Cell therapy is such a by-product. In fact, the tumor cell apoptosis that Yang Ping is currently studying is also a by-product of trial and error. However, this method is currently not suitable for non-Hodgkin lymphoma, but is suitable for osteosarcoma.

''Can it really be done?

Professor Zhang was silent just now. When he heard the young people's conversation, he felt that he had been abandoned by the times. The place where he worked every day could actually do such high-end operations.

Our stem cell experiments can even discover spatial guidance genes. It is very simple for us to do this. Moreover, my method is simple and fast, and the conditions are not high. As long as the sterility requirements are met, our laboratory's sterile The bacterial hardware conditions are fully met.”

Yang Ping said with great certainty.

This technology is nothing more than modifying the patient's T lymphocytes, and then amplifying the modified cells. After they are injected into the human body, the modified T lymphocytes encounter the specific antigens of tumor cells and immediately continue to expand in the body. , kill tumor cells accurately, and we happen to be qualified in this area, so as long as the patient is willing to participate in the experiment, we can use cell therapy. My method is simpler and cheaper.

Just as he said, Yang Ping took everyone to the stem cell laboratory to study how to use the laboratory's hardware conditions to transform T lymphocytes.

Li Yingtong did not leave. She took the past few days to familiarize herself with the laboratory environment and work procedures. He left China for the United States a few days later. She had to handle some matters in the United States before returning to China to officially start work.

She was very surprised when she saw Yang Ping and his team coming to the laboratory in large numbers and heard that they were doing cell therapy for patients.

As an outstanding doctorate in stem cell science, Li Yingtong knew the difficulty of CAR-T cell therapy. This was not a project that could be completed in a laboratory, so she was very curious about how Yang Ping could complete this project.

As the experiment progressed, Yang Ping was no longer a human being in Tang Shun's eyes, but a god, so he would believe whatever Yang Ping said. Moreover, under Yang Ping's influence, he himself became extremely confident and started to express his opinions on some scientific research ideas. I am more imaginative than before, more daring to think and do than before.

T lymphocytes are extracted from the patient, then modified, and finally reinfused into the patient.

Yang Ping told Tang Shun.

Tang Shun said worriedly: Technically there is no problem, but it involves intellectual property rights, and our CAR-T cell production requires a specialized laboratory, professor?

Yang Ping affirmed: In order to show respect for intellectual property rights, we bypassed their patents and followed the method I provided. It is very simple, has few steps, and does not require high conditions.

At this time, the A4 paper should be presented. Tang Shun knew the professor's habits, so before Yang Ping reached out, the pencil and A4 paper were already delivered to Yang Ping.

Yang Ping just thought about it for a moment and wrote down a new CAR-T cell production method on an A4 paper. Tang Shun looked at it and had to admire God's thinking. There were fewer steps and only existing equipment could be used to complete it. The sterility requirements of the stem cell laboratory can be fully met.

Professor Yang, once your method is introduced, the current mainstream methods in the world will lose their blood. Tang Shun exclaimed.

Li Yingtong was also surprised that Professor Yang could use a piece of A4 paper to present the world's top technology with just a few strokes. If this method were widely used, gold would be beaten into stone.

Yes, my method will turn gold into stone, but in order to respect the market, I will not launch it for the time being.

Most people can only see some things on the surface, but Yang Ping is thinking about deeper issues.

Song Zimo looked at the method on the A4 paper and joked: Professor, it's very dangerous for you to do this. The method you come up with at will can subvert the entire market and disturb other people's cheese. Those pharmaceutical giants will regard you as a thorn in their side. I'm really worried about you. safety.

''Don't worry, if anyone dares to take my idea, he will be destroyed first, because I have a lot of technical reserves in my hands. In order to respect the existing market structure, I just hold them quietly in my hands. , but once they want to deal with me, these technologies will automatically spread unrestrictedly on the Internet, allowing any company in the world to produce cheaply, instantly leveling the major giants with ordinary companies, and the foundations of giant companies will be destroyed instantly, but I respect the present Ecology, so I didn’t do this. I didn’t want to destroy the entire market mechanism and innovation mechanism. If someone forced me to do this like you said, then I could only snap my fingers reluctantly. Yang Ping also said jokingly.

In fact, the technical safety of these technologies has yet to be verified. It is impossible for Yang Ping to spread on a large scale for the time being. Once there are any security issues, it will be difficult to end them.

Therefore, Yang Ping is very cautious. When mature and safe, these technologies will slowly spread through the Internet. This requires an excellent rhythm, which can be the catfish of the industry without destroying the current incentive and innovation mechanism of the entire industry.

Okay, I have given the draft. Let's discuss how to do it and formulate a strict and standardized process. Yang Ping put down his pencil.

A world-class cell therapy requires countless researchers to work together to complete it. Now, here, it can be done with just a few people, a pencil, and a piece of A4 paper. What a magical place this is.

It is hard for Li Yingtong to believe that this is true. If she had not experienced it personally, she would not believe it at all.

——

Li Ruizhong heard Dr. Zhao's introduction that he could be an experimental volunteer. He hesitated a little, then thought for a while and said, I'll ask Professor Zhang before asking.

Obviously, Li Ruizhong only believed in Professor Zhang, so he came to the outpatient clinic again to see Professor Zhang. Professor Zhang took a break after seeing the patients at hand and chatted with Li Ruizhong.

Hearing that Li Ruizhong was worried about the experiment, Professor Zhang said kindly: Don't worry, it's very safe. This is our own technology, and it is free for you to use. If you use an outside one, it will cost 1.2 million per injection. At present, , this kind of cell therapy can cure your tumors, we consider your financial situation, so it is free of charge if you take the experimental volunteer route.

Li Ruizhong believed 100% in Professor Zhang. He was very moved when he heard what Professor Zhang said. He held Professor Zhang's hand and said excitedly: Thank you for your great kindness! Professor Zhang, you are a living Bodhisattva.

Don't say that. If you trust us and cooperate with us, we will definitely find a solution for you. Professor Zhang said kindly.

Li Ruizhong did not dare to waste Professor Zhang's time too much. There were patients waiting outside the door. He immediately said: I will go back to the ward to sign.

Back in the ward, Li Ruizhong found the supervisor, Dr. Zhao, to sign, and he agreed to be a volunteer and participate in clinical experiments. He didn't understand anyway, so he listened to Professor Zhang. If Professor Zhang said yes, then it was okay.

After signing, everything was ready. Song Zimo drew blood for Li Ruizhong personally, and then took the blood sample to the stem cell laboratory for cell separation. After separating the T lymphocytes in the blood, he purified the separated and purified T lymphocytes. The cells were placed in a constant-temperature refrigerator and sent to the Genetics Laboratory of Nandu Medical University for genetic modification. After the modification, the cells were sent to the Sanbo Stem Cell Laboratory for amplification. After amplification to a certain number, the cells were packed into sterile bags. bottles, the entire process is guaranteed to be sterile, but it is not difficult for laboratories conducting stem cell research.

The current mainstream technology takes about a month to complete the entire process, but Yang Ping's method only takes about 7 days, and qualified modified T lymphocytes can be obtained in 7 days.

In the past few days, Li Yingtong has been staying at Sanbo Hospital and participated in the entire process of Li Ruizhong's treatment. She now knows Yang Ping's method well. This method is indeed better than the current mainstream method, and the cost will be lower.

Li Yingtong checked and found that Yang Ping had applied for patents in many countries for this method. However, the patent did not mention the technical details. It just cleverly used several key information to protect its intellectual property rights. That is to say, patents can not only protect intellectual property rights, but also No technical details are disclosed.

But she was very curious, why no one bought or studied this patent? It turns out that the patent only discloses a few technical control nodes, which are impossible to truly realize, and most people may regard it as a patent with no actual technical value that has not been tested.

——

Li Gaoyang's newly relaxed brows were furrowed again, and they were furrowed deeper than anyone else's. The latest information sent shivers down his spine.

''Yes, our man personally participated in cell therapy. If this method were popularized, cell therapy would be as cheap as a pack of tissues. But he did not do this because he only expressed respect for the current ecology. Rolf said frustratedly.

I have to admit that he is a noble man. Li Gaoyang didn't know what to say.

He also said that he holds a large number of similar technologies in his hands. Under certain conditions, these technologies will spread on the Internet and become cheap technologies that anyone can use. Rolf believed what Yang Ping said. it is true.

Because the new method of CAR-T cells has shown its strength.

In this way, the technology Professor Yang is holding is like a nuclear weapon. Once used, it will destroy the entire medical industry, and we will not be immune.

Li Gaoyang understood the seriousness of the situation.

What we are facing now is not an ordinary person, but a god-like figure. We may not be in the same dimension.

Rolf didn't expect this to happen.

If this is really the case, I'm afraid we can only limit the war to commercial war, and we must not threaten his personal safety, otherwise we may really be destroyed.

Li Gaoyang couldn't be sure, because no one had seen the technology Yang Ping said he had. Judging from the public patents, he did have a large number of patents, but no one knew whether those patents could be realized.

But Li Gaoyang cannot deny it, because the new CAR-T cell therapy has really been realized.

So now that the information is not transparent, Li Gaoyang does not dare to act rashly. If it is true and a wrong move stimulates this genius, it will destroy the entire BG's century-old foundation.

Li Gaoyang took a deep breath. He had to reconsider the methods and limits of the war, because the other party held nuclear weapons in their hands, and BG Company could never take this risk.

No matter how powerful BG Company is, a balance has been achieved between it and Yang Ping. This balance prevents BG Company from going too far, and some despicable and shameless means that have no lower limit must be reconsidered.

Things are more complicated than we thought. It seems that we must treat this war with caution. Rolf said.

Li Gaoyang nodded: Let me discuss it with the elders. Why do I feel that the powerful BG cannot exert its strength at this time? What is the problem?

''I don't know either! Rolf sighed.

''In front of Professor Yang Ping, those scientists who had always been smart became stupid and made frequent mistakes in judgment. Li Gaoyang was very distressed.

Rolf said: I am also stupid now. Is he really that powerful? Does he have technology that can destroy us?

''If everything in the patent information is true, he can do it.

But many patents are just applied after thinking about them, without experimental testing at all, so they are invalid.

''The question is what if it's true.

''He said he had ten bullets in his gun. Now he has fired one bullet at you. Is it true? Do you still dare to rush forward and try?

I feel so stupid now.