The Godfather of Surgery

The development of digital human will inevitably develop toward microanatomy and functional human. The two are related. If microanatomy cannot be achieved, functional human cannot be realized. To achieve the goal of digital cell, that is, a digital cell, microanatomy must have the ability to simulate In terms of structure and function, it is necessary to realize the connection between cells to form tissues and tissues to form organs, so as to gradually realize the true digital human function. Yang Ping said his thoughts.

This is a summary of a large number of anatomical studies he has done in the system space.

That's right. I once participated in an academic meeting. An American team was studying the digital liver. They wanted to successfully simulate the anatomy and function of the liver, and they succeeded. So they used this liver as a model of drug-induced hepatitis. It was very realistic, but then the data gradually became distorted, and finally the model collapsed. The old academician of the project has a deep memory of this incident.

Thinking about it now, they didn't achieve the cellular level in structure, nor did they establish internal logical connections at the three levels of cells, tissues, and organs. They only developed digital functional modules with the goal of function, so this kind of simulation is superficial. Can’t stand the test.” Academician Xiang continued.

Yang Ping thought for a while and said: I went to Japan last year. The digital human being researched by the University of Tokyo has already achieved the goal of functional human beings, but they are the same as the Americans, taking the route of embedding functional modules. Applying to the extreme, hundreds of thousands of functional modules have been developed and placed in supercomputers, such as bleeding and coagulation, how much blood vessels are cut, how much blood is produced, and how long it takes to coagulate, all are simulated by functional modules, and there are countless supporting algorithms .”

Academician Xiang is also very familiar with the research on digital humans of international students, so Academician Xiang of the University of Tokyo is also very familiar with it.

Nandu Medical University used to be a leader in digital humans in the world, but with the iteration of technology, it gradually fell behind, and the plan for functional human research has not yet started. According to Yang Ping's analysis, Southern Metropolis Medical University still has the opportunity to strike late.

The old academician was quite relieved, it was rare for someone with such a high vision to be a young surgeon.

So we want to do research on digital cells? Then do research on the logical relationship between cells forming tissues and tissues forming organs, and finally digital cells forming a human body? Academician Xiang Lao has made very clear the entire route proposed by Yang Ping.

That's right, I think so. The top priority is supercomputers, and these researches must rely on supercomputers. Yang Ping said bluntly.

The old academician nodded: If the research is really successful, this is a cornerstone scientific research achievement, which can promote the technological progress of many industries.

The two chatted while eating, a bottle of wine, and a table of people hadn't finished drinking, and the drinking was superficial.

The meal lasted for five hours, but the old academician was still unsatisfied. Before leaving, Academician Xiang was reluctant to part with Yang Ping.

Yang Ping wanted to find a driver to go back, but the old academician refused to let him. He insisted that Professor He arrange an old driver from the logistics department of Nandu Medical University to be the driver and send Yang Ping back.

Everyone parted at the entrance of the hotel, but Academician Xiang insisted on sending Yang Ping to the car. When he got on the car, he was still discussing with Yang Ping about the upgrade of the digital human, and finally told Yang Ping to come to the house with Professor He when he had time.

It can be said that Yang Ping and Academician Xiang fell in love at the first sight and formed a long-lasting friendship.

Saying goodbye to the old academician, Yang Ping thought a lot in the car, and he was very moved by the attention of the old academician Xiang.

Academician Xiang is a leading figure in the national basic medical field, a researcher of many important national projects, and the most respected old academician of Southern Metropolis Medical University.

The older generation of experts, starting from Professor Zhang Zongshun, to Academician Feng Tiancheng, Professor Xiehe Liang, and then to Academician Xiang Lao, they are really pure people without many selfish distractions, and there are many things worth learning by themselves.

At that time, Academician Feng Tiancheng knew that his tumor could not be cured, and the success rate of the operation was very small, so he still insisted on surgery to gain experience for young people, and his will stated that an autopsy would be performed afterwards to accumulate pathological data.

Thinking about it, Yang Ping couldn't help feeling a lot of emotion in his heart.

Thinking of the upgrade of the digital human mentioned by Mr. Xiang, Yang Ping also had some thoughts in his mind. The digital human must develop towards miniaturization and functionalization.

Subtlety is relative, and it can be improved infinitely, but for now at least it must reach the level of cells, that is, the digital human is composed of digital cells.

For functionalization, at least it must be able to simulate the known basic functions of the human body, and the basic functions of each organ must be simulated.

For example, to cut a wound on a digital human, the wound bleeding, blood coagulation, the human body's response to bleeding, etc., all must be able to be simulated.

These data far exceed the previous digital anatomy human, and without supercomputers, the research cannot be completed.

As for my own stem cell research project, I can also rely on digital humans to conduct research in the future to improve efficiency.

Therefore, with the development of science and technology, computing power is also a precious resource, and supercomputers are the embodiment of computing power.

With the functional digital human, many research data of Yang Ping can be directly used for model development and indirectly applied to reality.

In the system space, Yang Ping actually has a lot of anatomical data, but he can't get it all at once, he can only get it out bit by bit as the subject progresses.

And you can't give the data directly, you can only teach others how to obtain the data, and let them accumulate the data themselves.

That is, only methods can be given, not data directly.

If you give some data directly, it will make people feel that these data are fabricated out of thin air and have no basis.

Of course, if some data can be explained clearly with realistic reasons, Yang Ping will directly show the data, which is very rare.

In short, the results in the system laboratory must be produced in a reasonable way. This is what Yang Ping himself said about the realization method, and it must be realized in a reasonable way.

For example, with the spinal external fixator, the entire experimental process is carried out in reality. All the data are made in reality, and none of the data is created out of thin air. This makes the whole process reasonable and reasonable. This is the realization of classic system laboratory results.

For the stem cell project, Yang Ping adopted a similar method, but because the project was too large, in order to start as soon as possible in reality, Yang Ping did not wait for the whole project to end in the system laboratory before starting the real experiment. The results of the final stage are realized in reality.

In this way, the whole experimental process will be led by myself, avoid trial and error, and directly follow the correct route, so as to ensure success and spend the least time.

After returning from Nandu Medical University, Yang Ping is more confident in the progress of the project. With the support of Nandu Medical University, the time for this project will be shortened a lot.

Just like the external fixator for the spine at the beginning, if there is no full support from Xiehe, it will not be so fast for the laboratory, for the animal model, and for a large number of Ph.D.s as front-line researchers.

Just imagine that there is a complete drawing of the aircraft, and qualified engineers, workers, factories, and raw materials are needed to manufacture the aircraft.

The results obtained by Yang Ping in the system laboratory are drawings, and he needs manpower, material and financial resources to realize them.

When Yang Ping came back, it was already twelve o'clock in the evening. Xiao Su hadn't slept yet. He had been waiting for Yang Ping, and fell asleep lying on the coffee table in the living room in his pajamas.

When Yang Ping entered the room, she rubbed her big sleepy eyes and said, I'm back!

Then I went to help Yang Ping prepare clean pajamas, and asked Yang Ping to take a shower and rest early.

Yang Ping hugged Xiao Su and kissed her on the forehead.

As a surgeon in a tertiary teaching hospital, he does both surgery and scientific research. He really doesn't have much time to spend with his family, so it is very important to have a wife who understands himself.

Xiao Su is an equipment nurse, and she can meet Yang Ping in the operating room every day, and the two of them can be regarded as staying together in another way.

Did you drink today? Xiao Su asked distressedly.

Yang Ping nodded: A little bit, eat with old academician Xiang. The old man is happy and wants to drink some wine, so he drinks with him, and the whole table can't finish a bottle of wine.

It's okay, I'm just asking, the old man seldom participates in the dinner, you have enough face. Xiao Su reached out and touched Yang Ping's nose.

Xiao Su is very familiar with the people and things of Nandu Medical University.

Go take a shower and rest early, there are so many surgeries tomorrow. Xiao Su told Yang Ping infinitely and gently. She not only prepared pajamas, but also squeezed toothpaste for her.

Recently, knowing that Yang Ping is busy with projects, Mrs. Su has relaxed a lot in urging the marriage.

Professor Su came up with a good idea, a new method in the new era, and asked Yang Ping and Xiao Su to pick a date to go to the Civil Affairs Bureau to get the certificate. As for the wedding, we can do it later when we have time.

So Yang Ping and Xiao Su wondered which day they would go to the Civil Affairs Bureau to get the certificate.

——

The next day, Yang Ping went to participate in the case discussion between Qin Xiaowei and Li Jun after a day of surgery.

The notification call from the medical office said that experts from other hospitals were also invited to participate in the discussion.

After Li Jun went offline, his vital signs were stable, and he was transferred to the Department of Respiratory Medicine. He spent almost two million yuan in the ICU, and finally saved his life.

During his stay in the ICU, because the arteriovenous fistula in both upper arms had been occluded, and a thrombus with a length of more than ten centimeters had formed, there was no way to remove the thrombus by thrombolysis, and the upper limb dialysis access was basically exhausted. A catheter was temporarily inserted to meet short-term hemodialysis needs. Later, arteriovenous fistula was performed on his left lower extremity. Not long after, the left lower extremity was blocked again, and it was replaced with arteriovenous fistula formation on the right lower extremity. Now the right lower extremity has occlusion again. signs.

The volume of fluid for each dialysis is getting less and less, and the effect is getting worse and worse. The urgency for Li Jun to get a kidney transplant is getting bigger and bigger.

And Qin Xiaowei is still in the ICU, but his vital signs are still stable, but because of severe liver failure, he can only rely on the artificial liver to maintain his life, waiting for the follow-up liver transplant to save his life.

After all, the artificial liver is not as good as the normal human liver. If the liver failure is only caused by liver disease, Qin Xiaowei can wait for half a year to a year by relying on the artificial liver. The initial stage of multiple organ failure, if the artificial liver is not effective in the follow-up, there is a high chance of triggering multiple organ failure.

Therefore, Li Jun is also eagerly waiting for a liver replacement.

After Li Jun knew about Qin Xiaowei's condition, he offered to donate his liver to Qin Xiaowei without hesitation, which was expected by everyone.

The fate of the two people is so wonderfully intertwined.

This kind of double-donated organ transplant is not very common, so the organ transplant center attaches great importance to it. At present, both operations are urgent and dangerous.

The more contradictory problem is that one of them is still in the ICU, and the other has just been out of the ICU. Both of them can hardly bear the blow of surgery, and the risk of surgery is extremely high.

Moreover, whether it is liver transplantation or kidney transplantation, when an organ is taken out from a human body, processed and then transplanted into another human body, there will be an ischemic period, which will damage the organ and lead to a decline in the function of the transplanted organ in the early stage. After liver transplantation, the aspartate aminotransferase is at High levels, and high levels of creatinine after kidney transplantation, the probability of occurrence of such events is more than 50%.

This is nothing to ordinary patients, but it is fatal to Qin Xiaowei and Li Jun. It can easily trigger multiple organ failure, and the whole organ function system will collapse.

During this period of time, Yang Ping was also thinking about when and how to perform the surgery for these two cases.

Director Liu of the kidney transplantation and Director Li of the liver transplantation also attached great importance to these two cases, hoping to complete the operation at the best time, but due to the complexity of the condition, they dare not act rashly.

Qin Xiaowei and Li Jun have no relatives, they are alone, they can make decisions on their own, and they will not receive other interference. Both of their donated organs have passed the ethical review, and the matching has been very successful.

In this case, there is very little external interference, and the rest is how the doctor decides the timing of the operation.

Speaking of which, these two are also bitter children. According to Dr. An, when Li Jun was seven years old, his mother abandoned him and his father, ran away with others, and took away the family's money. Later, when Li Jun was ten years old, his father was at the construction site. Died in an accident, Li Jun lived in a relative's house until he was 15 years old, and then came out to work to make a living.

Qin Xiaowei was not much better either. He had no parents since he was a child and grew up in an orphanage. He also came out to explore the world in his teens.

Fortunately, Qin Xiaowei raised money this time, and did not give up on Li Jun, and asked the ICU doctor to fight for Li Jun's life. If Qin Xiaowei hadn't insisted at that time, Li Jun would not have survived.

Li Jun is now willing to take the risk of surgery and donate part of his liver to save Tan Xiaowei.

However, Director Liu and Director Li of the transplant center have to consider various factors, and there are still many difficulties in the operation.

Director Liu and Director Li are in a dilemma. Doctors are at great risk if they do surgery now. If they don't do surgery now, the risk will be even greater for patients in the future, and their lives will be in danger at any time.

Do you want to take a gamble at this point? It is good for both of them if the bet is successful, but if something goes wrong, even if one of them goes wrong, it will be disastrous.

If you don't gamble, the two basically don't have much life.

Director Liu and Director Zhao were really not sure.

So everyone was called to discuss and discuss, and experts from the outer court were invited.

Especially now that Qin Xiaowei is a celebrity, the two directors are even more stressed. If something goes wrong, they may face the risk of cyberbullying.