Marvel – Immortal Path

Li Ang glanced at the Father Asgard in the glass jar, and said calmly, "As I said before, there are two explanations for the reason why lifeform will die.

One is that the lifeform automatically evolves the Death mechanism, and the other is that the lifeform is lost during operation.

For the first theory, the Urban Regenerative Medicine Department of the Academy under the leadership of Dr. Strange He believes that the goal of delaying the limit of physiological lifespan can be achieved by artificially intervening in the aging process." After that, he raised his hands, and there was a healthy spindle cell projection suspended above his left hand, and above the right hand. Suspended a bloated spindle cell projection.

"The ones on the left are normal cells, and the ones on the right are senescent cells."

Li Ang gave two illusory shadows and asked Thor and the others:" Can you see the difference?"

Thor scratched his forehead, carrying a hammer to battle and killing the enemy. It was really hard for the god of Thunder to recognize the cell map.

On the contrary, Luo Ji slightly raised her hand and said, "There is more damaged DNA in senescent cells."

"Yes."

Li Ang nodded, said: "According to common sense, multicellular organisms, especially senescent cells in the human body, will be replaced by new cells, but as time goes by, senescent cells will begin to occupy the pit without shit, and are retained. , Promotes the aging of multicellular organisms.

This abnormality is due to the shutdown of the p53 protein in the human body.

P53 gene is a tumor suppressor gene located in humans Chromosome 17p13.1, which encodes a 53kD nuclear phosphorylated protein consisting of 393 amino acids, is called p53 protein.

It is responsible for cell cycle regulation, DNA repair, cell differentiation, and cell apoptosis.

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Once the p53 protein shuts down, the senescent cells cannot be targeted to Death, and eventually become congested inside the body, accelerating the body’s aging process."

Speaking of which, Li Ang glanced at the Odin family , Found that only Luo Ji and Queen Flia can understand, Thor and Odin are in a daze.

Flya, the queen of heaven, can understand it because she is quite eager to learn. After selling herself in the Academy City, she knew her shame and then courageously, learning knowledge like a sponge.

And Luo Ji can also understand, it is completely because of the last time the "Frost Giant Sex Chromosome Disorder Incident" was too deeply injured.

For this god of lies and cunning, it is difficult for her to bear this ignorance and the feeling that the situation is completely out of oneself's grasp.

Therefore, while Luo Ji became an idol, she also made up for a while of genetic biology.

From this point of view, she is many times stronger than a certain Thor who only likes to think with muscles.

Li Ang smiled and said: "On this basis, Dr. Strange did further research.

They found that it was a transcription called FOXO4 The factor combines with p53 to prevent p53 from functioning and cannot make senescent cells die.

This FOXO4 transcription factor is quite an overbearing president. It can force p53 to have a relationship with it. The solution is to inject a Alternative to FOXO4, FOXO4-DRI short peptide.

This short peptide is a D-retroinverso isoform. Simply put, the L-type amino acid is replaced with the D-type, and the backbone direction is also reversed. .

FOXO4—DRI short peptide has a higher priority than FOXO4, and is more domineering than the domineering president. It can deprive FOXO4 of the'mating rights' and preferentially bind to P53 without preventing the latter from continuing. Play a role.

From a macro perspective, this short peptide can target senescent cells to undergo targeted apoptosis, thereby promoting new cells to replace old cells, thereby delaying or even preventing the overall aging process of individual life."

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I have to say that the day after the day, Freya’s brain is turning fast. After this time, I have guessed Li Ang’s intentions, and said a little excitedly: "Then if this FOXO4-DRI is injected into Odin’s body , Let his body, which is on the verge of aging and collapse, start metabolism again, destroy old cells, and produce new cells.

My husband does not need to die?!"

Not only did Thor's face flashed with excitement, but even Odin in the glass cylinder showed a slight mood swing.

He just saw through the essence of some things and looked down upon the world, but he didn't mean he wanted to die.

If lifespan can be extended for another minute, 1 minute, or even one month or one year, who wants to die?

Unexpectedly, Li Ang shook the head and poured cold water on Freya and the others, who was so excited, "It's not that simple.

FOXO4——DRI short Peptide is just a test product. Even with the addition of Ultron, the computing power of the entire scientific research project has been qualitatively improved.

It is just a few transcription factors that have similar effects to the short peptide.

Odin’s divine body has long been on the verge of its limit. It is similar to the realm of the five decays of heaven and man. Every part of his body begins to decay and decay.

All these transcription factors are tied together to control If the adult'senescent cells target apoptosis medicament', if it is directly imported into Odin's body, it will only cause the cells throughout his body to collapse instantly and become a pool of ignorant cell soup."

Freya and the others wilted in an instant, and the gap between hope and disappointment was too great.

This is actually Odin’s own reason. If he is not Aesir’s Divine King, but is just an ordinary and ordinary Earth old man, he can completely rely on the primordial cells of the underground base of the Academy. .

The primordial cells that have been able to multiply by Infinity for a long time can invade the host's body, siege the city among the cell tissues, replace most of the host's body, and allow the host to achieve another degree of immortality.

However, the powerful body of Aesir can block the erosion of primordial cells, making the latter unable to help the former to continue lifespan. We must rely on our own body's life mechanism in order to counteract aging.

Just when Freya and the others were disappointed and desperate, Li Ang said slowly: "In the first lifeform Death explanation. The senescent cell targeting apoptosis containing FOXO4-DRI short peptide Death medicament can indeed play a part.

However, targeting apoptosis medicament is like a double-edged sword, which will break the dynamic balance of Odin’s cells.

This At that time, we can turn our attention to the second explanation of lifeform death."

second explanation?

Luo Ji and Freya hurriedly refreshed their spirits. According to their little understanding of Li Ang, this second explanation is the highlight.

Sure enough, Li Ang said slowly: "The second explanation of the cause of lifeform death is the'principle of wear.'

Free radicals generated in the process of mitochondrial metabolism can damage DNA and cause Abnormal damaged cells gradually accumulate and form senescence.

This is almost an unavoidable thing. Thermal exercise and regular metabolism in the human body will inevitably lead to the gradual breakage of chemical bonds in proteins.

It is precisely this kind of chemical bond breakage that accumulates more and more necrotic cells, and the human body gradually ages.

In a professional way, it is the gradual decrease of molecular fidelity and The gradual increase in molecular disorder has resulted in changes in molecular structure, resulting in changes in the overall function of cells, and ultimately leading to senescence'."