Forty-eight years of Qianlong

Chapter 282 Dr. Hong's Native Anti-Inflammatory Medicine

Since Zhao Xin entrusted Lin Ziping with a heavy responsibility, the old man's body is extremely important.

In history, Lin Ziping was banned by the shogunate soon after he published "Hai Guo Bing Tan" at his own expense in 1791. He was also ordered by the shogunate to return to his home in Sendai to "live in seclusion" and died of illness two years later.

So on the second day, Sheng Haizhou, who received Zhao Xin's order, took Lin Ziping, who hadn't eaten breakfast, to the hospital for a physical examination.

Although Hong Tao hated the islanders, he heard that the old man in front of him was the director of the "Surveying and Mapping Bureau" appointed by Zhao Xin, and he was going to help Beihai Town draw a map, so he didn't dare to neglect.First blood test, urine test and stool test, followed by X-ray echocardiogram, followed by Lin Ziping complaining non-stop.

Later, Sheng Haizhou took Lin Ziping to find Wu Xianhou.

Now the Wu brothers have relied more and more on various inspection reports to see a doctor.Although the four diagnostic methods of traditional Chinese medicine have been passed down for more than 2000 years, this method relies too much on consultation experience and personal self-cultivation ability; many doctors in this era are only proficient in a certain subject throughout their lives, and it is difficult to become a general practitioner.

However, Beihai Town now has a small number of doctors, and what it needs most is generalists who can deal with common diseases, frequently-occurring diseases and general emergencies.So in the two years since they came to Beihai Town, the Wu brothers have changed from specialist doctors to general practitioners. What they see most every day are headaches, brain fever and injuries caused by industrial accidents.

Wu Xianhou took Lin Ziping's various inspection reports and read it, and after some consultation and pulse, he judged that the other party should be the "upper flu" that Dean Hong mentioned before, and it was an upper respiratory tract infection.

These days, it is very common for the wind-cold to turn into pneumonia. Sometimes even after the fever subsides, the inflammation remains latent, and in the end it is a lung infection and even the end of the game.

Yong Lian, the son of Emperor Qianlong and Empress Fucha next door, caught a cold and had a fever because he went to the northern suburbs to review, and finally lost his life.

The ancients' treatment for typhoid fever was either "Guizhi Decoction" or "Mahuang Decoction". The effect was to sweat and dispel cold, and only the rich could afford it;But even the emperor's son couldn't be cured, which shows the effect of this thing.

After coming to Beihai Town for two years, Wu Xianhou has seen a lot of "miracle drugs" in Beihai Town, and knows how to deal with them, so with a swipe of a pen, he prescribed "penicillin injection", one injection a day, for three consecutive days .

Right now, the Beihai Town Hospital's penicillin powder is divided into three types, 80 units for the people of this time and space, and 160 million and 400 million units for the time-travelers.The shelf life of this thing is at most three years, and it doesn't make much sense to buy too much and stock up.

Although the price of penicillin powder in another time and space is not expensive, after Zhao Xin came back from Guangzhou, he actually asked Hong Tao to take time to develop the development of penicillin.

Hong Tao was stumped now.The acetylsalicylic acid mentioned earlier has not been solved yet, and if we make a synthetic penicillin, it will kill people!
Don't talk about boiling willow bark, the purified willow bark is called "salicylic acid", and the very strong organic acid extracted from willow glycoside is called salicylic acid.And salicylic acid has a big problem, that is, it irritates the gastrointestinal tract and is difficult to take.In addition, light extraction from bark cannot form industrialized production at all.

The production of modern salicylic acid is to make sodium phenate by reacting phenol with sodium, and then introduce carbon dioxide under normal pressure for hydroxylation reaction to produce salicylate, and then acidify with sulfuric acid to obtain crude salicylic acid. Salicylic acid is then refined through sublimation.

Hong Tao waited for almost a year, but the problem of industrial production of salicylic acid has not been solved.

The most important thing here is the high-pressure reactor. Zhao Xin can buy a ready-made one, but the problem is not that he wants to produce it himself.For more than a year, several workers under Zhao Liang went back and forth to process more than a dozen, and now they can finally produce a qualified tank body.

The main material of this thing is not complicated, and it uses ordinary stainless steel plates. Beihai Town can't make it right now, and all the materials are in stock.However, due to the poor craftsmanship of the workers, the high precision and smoothness of the contact surface of the tank cannot be guaranteed, and the first few failed.

During the whole process, Zhao Liang watched coldly from the side, not interfering at all.If he wants to help, he will definitely do it, but he can't do everything!
Several workers who were born as blacksmiths pondered for a long time, and finally thought, if the big one can't be made, can't we make a small one first!So when Hong Tao finally saw the finished shell of the reactor, several months had passed.

There is only one shell and it is not finished!Pressure gauges, vapor-liquid phase valves, temperature sensors must be installed on the lid of the kettle, and a bursting film must be pasted.In addition, there must be a lot of magnetic couplings and cooling water jackets.

At this point, all the blacksmiths are completely blinded, this is really impossible!
But being able to make the shell of the reactor means that the people in the workshop can already make old-fashioned boilers. At least Zhao Xin no longer needs to buy public baths and water boilers everywhere.

Hong Tao thought about the matter of penicillin for a long time but couldn't come up with a clue. The day after Lin Ziping finished the inspection, Zhao Xin called.

"Dean Hong, can this penicillin be produced?"

"Mr. Zhao, I'm a clinical student, not a biotechnology student. You need to know how much the wholesale price of 6-APA is now? It costs 30 yuan per kilogram. If you buy a lot, it's cheaper than Chinese cabbage. There is no need to torment this!"

On the phone, Hong Tao explained to Zhao Xin, a half-assed Mongolian doctor, that there was absolutely no need for penicillin now.

"As far as I know, there are no manufacturers that synthesize penicillin from scratch anymore. They are all semi-synthetic or bio-fermented. Moreover, the synthesis of semi-synthetic penicillin uses 6-aminopenicillanic acid (6-APA) as the raw material. It is obtained by joining various amide side chains by the acid chloride method or the acid anhydride method. Moreover, the current domestic production capacity is [-] tons, and most of them are used for export.”

"Oh! So that's the case." Zhao Xin rolled his eyes and heard a bunch of terms he didn't understand at all, and finally heard about overcapacity. No wonder the price is the same as that of cabbage.

Don't you see how much movement was made to save a man-made penicillin in "Benevolent Doctor", but it may not work in the end.If industrial production is used for medical use, safety must be the first priority.

At this time, only Hong Tao continued on the phone: "Mr. Zhao, my opinion is that it is better to use allicin than penicillin. It is also good for sterilization and anti-inflammation. The process is also simple and can be used by both humans and animals. Mr. Zhao, Just let go of the mycelium."

How could Zhao Xin understand this!He had only heard about allicin before, but he really didn't understand the details.After Hong Tao briefly explained the medicinal effects of allicin, he quickly asked, "Is this not difficult to make?"

Hong Tao laughed and said, "Pounding garlic, what's the difficulty? At most, use a blender. Solvent or steam distillation extraction is similar to making perfume."

It was easy for Hong Tao to say it, but when he actually made it, he realized that there were a lot of troubles.

The first is that the taste is too great!
It is said that there is no allicin in fresh garlic, only alliin.When the garlic is cut or crushed, the alliinase in the garlic will be activated to catalyze the decomposition and synthesis of allicin.

This thing is so outrageous that if some brave woman eats garlic before giving birth, the baby's first cry will be filled with the smell of garlic!That scene, tsk tsk~~
The second is dosage.One kilogram of garlic can only produce 8 mg of allicin at most, so if someone wants to achieve the effect of reducing inflammation and curing diseases by eating garlic, the daily dose should be at least 160 mg.

Didn't I say it before, garlic is cut or crushed to produce allicin.In other words, you have to eat twenty kilograms of mashed garlic.Whether it can cure the disease is still a matter of opinion, it is certain that it will die.
In the afternoon, Hong Tao and his assistant carried a box of equipment to the canteen in Beihai Town.This thing can't be made in the hospital, it can smoke everyone out, and some people will "YUE".
The first is mashed garlic.

Twenty kilograms of fresh garlic, more than a dozen women working in the big cafeteria lined up in a row, with a garlic mortar in front of each of them, and everyone started pounding and pounding.

To prevent oxidation, Hong Tao's assistant puts a portion of the mashed garlic into a glass container and seals it up for enzymatic digestion.After almost one kilogram of mashed garlic filled two glass bottles, Hong Tao went out.

In order to make the operation simple and convenient, Hong Tao did not choose to use ethanol for extraction, but used earth distillation.

A group of women watched Hong Tao take out the glass decanter and alcohol lamp from the box, wondering what kind of treasure it was, when they saw Hong Tao, who was wearing gloves and a mask, pour the mashed garlic from one of the bottles into the decanter.

In fact, it can be used without a decanter. The ancient man-made wine was fumigated to extract the liquor, which is the same reason.Use iron sheets to make a pot, connect a copper pipe to the lid, wind the copper pipe a few more times, use cold water or a damp cloth in the middle to promote condensation, and put it on the stove to burn it.

However, the temperature is still very important, and the extraction effect is best below 80 degrees.

A few hours later, two bottles of light yellow and clear allicin extracted from [-] kilograms of garlic paste finally came out, and a strong garlic smell wafted through the operating room of the kitchen.

At this time, the kitchen, including everyone's body, was full of garlic smell, and even the cooks in the cafeteria were suffocated, one by one came in with their noses covered, and they went out with their noses covered.

After Hong Tao returned to the hospital with two bottles of allicin, he found that everyone who approached him wrinkled his nose until he finally broke out when he saw Director Liu.

"Hey! It stinks, you got into the garlic basket?!"

"Ah?" Hong Tao sniffed himself, his nose was already numb from the garlic.

"Hurry up and take a shower in a while! Don't enter the door until you wash off the smell!" Director Liu clutched his nose and walked away.

Hong Tao was stunned for a while, then shook his head and smiled wryly.

Now it's time to test the effect of the extracted allicin, who should be the "guinea pig"?This thing is too irritating to the stomach and intestines. If you take it directly, you may get gastric perforation.In another time and space, it is made into capsules and dissolved after entering the small intestine.

After thinking about it, Hong Tao first went to the injection room to get a bottle of glucose in a plastic package, took a disposable syringe and an infusion needle, then changed into his clothes and went out, stepping on the snow, and strolled to the horse farm.

Ever since Liu Zheng went to Guangzhou, Yalha was in charge of the racecourse.This poor man now has more than 200 refugees, taking care of thousands of Mongolian horses.

Seldan kept asking him to find another wife, but Yalha always shook his head; the departure of his family members at the same time stimulated him too much. Although Yalha looks smiling every day now, the scars in his heart have never been healed. heal.

"Lao Ya, how busy are you?" Hong Tao opened the door and walked into the office (office) of the racecourse, and saw Yalha sitting cross-legged on the kang smoking a cigarette.

"Hey! Doctor Hong, why are you here?" Yalha looked up and saw that it was Hong Tao, and hurriedly got up to greet him, and boiled water again, preparing to make tea for Hong Tao; it was Hong Tao who performed the amputation of his fingers and toes.

"Don't be too busy, Lao Ya, I came here to ask you, have any of the horses in the racecourse suffered trauma?"

Yalha hesitated when he heard the words, and immediately replied: "You really asked. The day before yesterday, two stallions got into a fight for some reason, and one of them was bitten."

"Bite it?"

Yalha nodded and said: "It's still not broken, I asked someone to find some herbs and wrap it up."

Hong Tao was overjoyed, and hurriedly said, "Take me to have a look."

Yalha thought in his heart that Doctor Hong changed his profession to a veterinarian?

The bitten stallion was alone in a pen in a shed, drooping and looking listless.The wound at the lower end of the neck was wrapped in a white cloth, and some green liquid of herbs was faintly oozing out.

Hong Tao asked Yalha to untie the white cloth first, and then remove the herbs on the paste.Yalha didn't know what he was going to do, but as a doctor, everything he said was right and he had to listen.

During the process of rubbing the herbal medicine, the horse must have been touched by the wound, shaking its head and neighing in pain, and jumping restlessly.Yalha calmed down for a while before calming down.

Hong Tao asked Yalha to lead the horse to the fence and take a closer look.Maybe the worker arranged by Yalha didn't work carefully, or maybe there was something wrong with the herbal medicine, the wound didn't heal at all, and it had already started to inflame.

When Yalha saw it, he was so angry that he cursed at the worker.The worker had only been at the racecourse for more than a month, and he knew that he had made a mistake, so he just bowed his body and kept admitting his mistake.

Hong Tao waited until Yalha had learned the lesson, and then took out the glucose and allicin in his coat pocket and placed them on a wooden board in the stable. He put on gloves, and first took 60 mg of allicin with a syringe. Then inject it into 500 ml of glucose injection, shake well, and connect the infusion needle again.

He had heard from Liu Zheng once before that to infuse a horse, the needle needs to be inserted through the jugular groove, which is the long tendon-like part under the horse's neck.Although the jugular groove of a horse is very long, only the middle third is safe; the top is too close to the brain, and the bottom is too close to the heart.

Hong Tao asked Yalha and the worker to calm the horse, and he stretched out his hand to pinch the lower end of the jugular vein. After the blood vessel was exposed, he quickly inserted a needle sideways.

"It's okay! The craftsmanship is not wasted!" Hong Tao praised himself in his heart.

The horse was also a little dazed, and shook its head uneasily, and Yalha hurriedly stroked the horse's head to comfort him.After seeing that there was no problem with the return of blood, Hong Tao unscrewed the flow regulator on the infusion tube.Because it was the first time to infuse a horse, Hong Tao couldn't grasp the flow rate well, so he chose the middle flow rate.

After about four or ten minutes, the infusion was completed. Hong Tao pulled out the needle and said to Yalha, "Don't apply the medicine first, just wrap it in a cloth. I'll come over at noon tomorrow."

After two consecutive days of infusion, the wound inflammation of the horse was stopped.But the horse exuded a garlic smell mixed with sweat, which could make Hong Tao stumble.

Done!The next step is to detect the content of allicin in the extracted allicin solution to improve the extraction rate.

A few days later, Chen Qingsong, who heard the news, immediately issued an order to the civil affairs clerks, informing all the residents of Beihai Town and Fuldan City that from now on, every household must grow garlic!
(End of this chapter)