Rebirth of the God-level Xueba

"Show me your experiment log."

"How are you doing now?"

Yang Rui came to the laboratory and asked all the way. He rarely does this. In fact, few heads of large laboratories do this. On the one hand, there is no time, and on the other hand, there is insufficient ability.

It is obvious that there is no time. The person in charge of any large laboratory is a busy guy. They either spend time in the laboratory or use time to raise funds. If anyone wants a The person in charge of a high-level laboratory circled him all day, so he had better be the Flash or some other eel.

Insufficient ability is another kind of helplessness. The work in the laboratory is no longer known work. No matter how easy the work of the scientific research dogs is, it is still on the edge of the unknown world. If the person in charge of the laboratory can explain all the problems, he will also There is no need for the scientific research dogs to work hard to do experiments. Therefore, the unknown problems encountered by the scientific research dogs are also unknown problems for the person in charge of the laboratory. Perhaps the latter has more experience to solve these problems, but the same It takes a lot of energy and time.

Therefore, the more high-end laboratories are, the less the person in charge of the laboratories can give hands-on guidance.

Give systematic training, point out the direction of development, provide cutting-edge information, and high-level brothers, who are basically the heads of high-end laboratories, and they can provide the most valuable things. Of course, if you consider more secular, high-end laboratories have more abundant experimental resources and social resources, which is also a big plus.

However, Yang Rui is not an ordinary laboratory manager.

In the face of the unknown scientific world, the heads of other laboratories, perhaps like the scientific dog, are waiting for the results of the exploration with their eyes darkened. In the best case, they are just searching and searching with a candle.

But for Yang Rui, the world of science in the 1980s was even brighter and clearer than the playground under the noon sun.

Therefore, he is indeed capable of hand-in-hand guidance.

However, in the past, Yang Rui didn't do this. It was mainly because he was not confident enough. In addition, he didn't know enough about the details, especially the details. Only after several years of intense laboratory life did Yang Rui have a high level of detailed domain control.

The most important point is that there was no need to guide scientific research dogs hand in hand before.

If a dog with 0 offense and 0 defense is already able to beat the world, why use a lot of resources to upgrade it? Just like enemy tanks only have 40mm armor for defense. We already have anti-tank weapons with 60mm penetration. Reproducing anti-tank weapons with 100mm penetration is obviously not a priority.

Until now...

If the research on PCR, the scientific research defense system encountered is 40 mm armor, the defense system of G protein coupled receptors is about 400 mm armor.

The defense level of PCR is the defense level of Japanese small tanks, and the defense level of G protein-coupled receptors is the proper maritime battleship.

And the three-dimensional structure that Yang Rui worked hard to create is almost equivalent to the core part of the battleship G protein coupled receptor. You can't buy the 400mm reinforced armor, you can't buy it, you can't buy it...

In the face of such a powerful enemy, it is impossible not to upgrade the research dogs.

Especially when encountering a scientific research dog like Wu Qi, Yang Rui decided to start with the strongest since he wanted to develop his talents and provide resources.

Yang Rui is an experiment record, and he looked at the experiment record, pointed out the mistakes and pointed out the direction casually.

"Control your reaction temperature."

"You have to think more about the use of solvents. Why should the concentration be set to the current value? Is it necessary to use these types? What is the basis for selection?"

"Big mistake, start over!"

Yang Rui spent the morning killing a pair of labs.

The students in the laboratory are no more. Several professors who joined the laboratory not long ago were shocked by Yang Rui.

Since His Excellency Liebig, the teaching mode of high-end laboratories has not changed much in the past 100 years. At that time, the Giessen laboratory always reduced theoretical teaching to a minimum, and most of the time guided students to do experiments and adopt Train them in a three-step approach. The practice of entrusting the teaching of beginners to skilled students is exactly the same as the postgraduate education of later generations.

Today, Yang Rui is doing the opposite.

When he reached Wu Qi's side, Yang Rui couldn't stand even more.

"There is no problem with the operation. What do you think of the results of this experiment." He asked after watching Wu Qi finish a set of experiments.

Wu Qi just straightened up, breathed a sigh of relief, and felt pressured to breathe. He quickly turned his mind and said, "From the analysis of this substrate experiment..."

"Don't analyze it from an experiment. You have done experiments for so many days. What are your thoughts?" Yang Rui interrupted Wu Qi instantly.

Wu Qi was stunned again, and he couldn't help but hesitate. Needless to say, the difficulty of analyzing an experiment and analyzing a bunch of experiments was unnecessary, and he was not prepared to let him say it all at once.

Yang Rui waited quietly for a few minutes. He had higher expectations of Wu Qi, so he also made extremely high demands.

However, Wu Qi didn't seem to be in the state yet, and his head lowered was like a statue.

Yang Rui didn't feel disappointed, he just felt a little lost in surprise.

"in this way……"

"I think……"

As Yang Rui spoke, Wu Qi just raised his head to speak.

"You speak first."

"You speak first."

The two people spoke in unison again.

Yang Rui couldn't help laughing, shook his head, raised his chin, and motioned: "Did you come up with the result?"

"Some ideas..." Wu Qi didn't dare to say too much.

"you said."

"Yes." Wu Qi thought for a while before saying: "I recently did an experiment and I paid more attention to hydrogen bonds."

Hydrogen bond is a common intermolecular force. In middle school, high school, and high school, the value is basically equal to a "-", but in advanced research, hydrogen bond is very changeable.

Yang Rui didn't expect Wu Qi to speak from this perspective, with an "oh" and said, "You talk about it."

"Yes." Wu Qi paused again, and said: "I read some documents and think that the directionality and saturation of the hydrogen bond is the driving force that causes the acceptor and the substrate to associate, and then forms the complex, and causes An important reason for molecular recognition."

Yang Rui nodded slowly: "The focus of the G protein-coupled receptor we are doing now lies in molecular recognition."

"Yes. So I have been paying more attention to hydrogen bonds recently. I think that if we take into account the factors of hydrogen bonds in the classification of substrates, we should be able to screen out some substrates. These substrates should have a higher probability. Used in the analysis of the conformation." Wu Qi said very slowly, even a paragraph of words was broken up into several sentences by him.

However, what Wu Qi said is indeed worth thinking about, including Yang Rui, who also listened very seriously.

Moving towards the right goal may be "one road from Huashan since ancient times", or "all roads lead to Rome". Under the circumstances of restricting funds and resources and restricting the scientific foundation, the probability of the former is greater than that of the latter, but After the various restrictions are removed, the possibility of the latter's emergence increases.

What Wu Qi proposed is a road that Yang Rui has never seen anyone walk through. In fact, it can’t be regarded as unworked. Scholars need to make the conformation of G protein-coupled receptor~www.readwn.com~ They chose some. The method does not include the hydrogen bonding pathway. Later, the conformation of the G protein-coupled receptor is completed. Whether there are other ways or ways to reach the goal of conformation, it loses its practical significance.

As for now, Yang Rui feels that he can go a step further.

Anyway, he has so many scientific research dogs under his hand, and it would be nice to send a smarter one to explore the way.

Thinking of this, Yang Rui nodded slowly, and said: "You write a report to me to explain your thoughts. Will you write this kind of report?"

"I will." Wu Qi nodded in excitement, and submitted a report directly to the laboratory director.

Yang Rui nodded and said, "I'll give you a separate fund, 10,000 yuan. After the report is written and passed, you will try the hydrogen bonding method alone. If it can be done, you will be allowed to publish the paper independently. Of course, if it fails, then go back to the regular route."

"I will do it." Wu Qi suppressed his mood, full of heroism as a confidant.

...