Rebirth of the God-level Xueba

Sleepwalking Dafa is often heard in scientific stories, most of which are sentimental to the scene, plus the feelings of sleep.

The discovery of the benzene ring, the invention of PCR, and even the discovery of the DNA double helix are all successful cases of sleepwalking in Dafa.

The researcher dreamed back at midnight, and when he woke up, he solved the problem that he had studied for a long time. This kind of epiphany model is very popular in various scientific stories, and ordinary people also pay the bill very much. One of the messages included is that ordinary people can actually make superb scientific research results.

Therefore, young people, middle-aged people, and old people who are interested in science will laugh at the scientist's sleepwalking story.

Of course, ordinary people can't actually make outstanding scientific research results.

Ordinary people can make some small inventions, add an eraser to the pencil, there is no problem, but the coverage of basic science has exceeded the ordinary level, and there are many people who have not been able to touch the world's cutting-edge science after reading a Ph.D. Don't talk about the actual discovery process, but still follow the scientific process.

However, the second of sleepwalking Dafa is that it is a reasonable and legal reverse push-I think the double helix is ​​very handsome, so I gave it a try. It turns out that the double helix is ​​really good. It is the best guide for using sleepwalking Dafa.

Yang Rui hopes to make the three-dimensional structure of the G protein coupled receptor. The first step is to make a conformation of the transmembrane region of the G protein coupled receptor.

To put it bluntly, such a conformation is worth half of the Nobel Prize.

If you have a basic biologist to make a conformation of the transmembrane region of a G protein-coupled receptor, it is almost enough to win the Nobel Prize. Of course, it is right to share it with others.

It is such an important scientific achievement, but the conformation of the transmembrane region of the G protein-coupled receptor is a very simple image when displayed in front of the public.

Just like the DNA double helix, which is formed by two snakes, the conformation of the transmembrane region of the G protein-coupled receptor can almost be described as an image of 7 springs mixed together.

The "molecule that can cross the membrane seven times" is a powerful protein molecule comparable to Yoshijiro. It may be the most powerful molecule in the human body, but it is ultimately composed of seven tentacles, each of which is like a thick spring wire. Yes, the image can’t be said to be pretty.

However, such an image is not something you can have if you want.

The tentacle monster composed of seven tentacles is easy to draw, but the structure of the G protein coupled receptor has to withstand scrutiny.

What Yang Rui is planning to use is sleepwalking Dafa, not really planning to sleepwalking, it conforms to the current cognition and judgment of the scientific community.

This is what Yang Rui was looking for.

He has to see what basis he has for "sleepwalking".

The three intracellular loops and the three extracellular loops were figured out in the 1950s and 1960s. The first two intracellular loops were small, and the third intracellular loop was larger. It took a few years to determine. As far as the transmembrane spiral sheet of the receptor is concerned, spirals I-IV form one sheet, and spirals V-VII form another sheet. This understanding is relatively new.

In addition, the most important thing is the image data from the electron microscope and X-ray.

Although protein is such a small unit, the technology of the 1980s is enough to take a rough look.

However, the transmembrane conformation of G protein-coupled receptors focuses on the word transmembrane.

What scholars want to figure out most is why G protein-coupled receptors can span membranes, and they span seven kinds of membranes.

The core problem that needs to be solved for its transmembrane conformation is also here.

Yang Rui looked at the materials while making sketches on paper, but it was completely contrary to what other scholars did.

Scholars of this era, to study the transmembrane conformation of G protein-coupled receptors from scratch, they must first imagine the placement of seven tentacles in their minds, and then consider the relationship between them, and then examine their relationship with the existing ones. Whether the known structure information is consistent, and explain the inconsistent part...

This is a very tedious, detailed and even annoying job.

The DNA double helix structure has only two strands, which is a game for many laboratories. The G protein-coupled receptor has seven strands. You can imagine the difficulties.

It's just that what Yang Rui wants to do is not addition, but subtraction.

After 30 years, the transmembrane conformation of the G protein-coupled receptor is well known, and the three-dimensional structure is well known, not to mention the first step conformation.

However, Yang Rui couldn't directly take out the conformation of later generations, because of certain restrictions, the academic circles still don't know it.

At the same time, Yang Rui has to determine the research progress of his laboratory and has reached a corresponding level. It is best to infer the conformational data from the research progress of the laboratory-saying that it is necessary to draw pictures. In the final analysis, all Images are all expressed in numbers.

And numbers, numbers naturally have to be based.

Yang Rui turned over all the information, and barely gathered 70% to 80% of the content. As for the rest... naturally, he had to force others to do it.

"When I slept last night, I thought about it carefully. The transfer of the 7 helical chains must have a certain effect. I tend to use them to recognize the substrate, and it is a specific recognition substrate. Molecule..." Yang Rui said as he wrote two lines on the blackboard in the laboratory:

1. Determine the contact between the 7 helices and the substrate molecule.

2. Describe the local conformation according to the substrate molecule.

The simple twenty or thirty words is like a container smashed on a jeep, and everyone can't breathe.

"When you sleep, do you think about these things?" Gu Qiang looked at two questions and wanted to complain.

Yang Rui nodded steadily. Sleepwalking Dafa is good. Fortunately, the explanation is simple, eliminating a series of logical problems.

Gu Qiang felt helpless, curled his lips, and said, "I'm just wondering how you can sleep."

Yang Rui coughed twice and said, "You answer, I will definitely be able to fall asleep."

"There is no ready-made solution, right?" Professor Man Hai asked.

"No."

"So, all have to be tested?"

Yang Rui shrugged.

To test the contact between the seven helices and the substrate molecule, it is natural to use the substrate molecule and the G protein-coupled receptor to test. There are hundreds of substrate molecules, and the test is naturally even more numerous.

Professor Man Hai just felt black in front of his eyes~www.readwn.com~ and muttered: "No wonder you asked them to make so many bovine rhodopsin proteins."

"It's still our dominant period. Let's work hard. When the project is over, everyone can go abroad." Although Academician Zhu came forward to do work and the trip abroad was rejected, it was still a morale injury. Yang Rui could only take the opportunity to draw cakes.

Man Hai also took the opportunity to show his loyalty, saying: "As long as you can make it, it doesn't matter if you don't go abroad."

"Achieving results is the focus now." Yang Rui quickly pulled the topic over and said: "I have some initial ideas about the conformation of G protein coupled receptors. I hope everyone can do their own thing. The work at hand contributes to the completion of the project..."

Yang Rui did not take out his sleepwalking flow composition as a whole, but he still made a few simple partial pictures and handed them to several researchers.

A group of people studied silently, some who couldn't understand, staring blankly, and some who could understand, and began to look for old information for comparison in a daze.

Yang Rui didn't care about it, but felt a little drunk after drinking.