I can extract side effects

"This, this is the finished drug of γ-secretase inhibitor?"

Chen Yiqing opened his eyes full of red blood, looking at the pile of white powder in the glass container, feeling like falling into a dream.

He felt that all this was too unreal. The new drug for Alzheimer's disease that he had been thinking about for more than ten years was placed in front of him. He couldn't help but think of his deceased grandma, and tears filled his eyes.

Wen Renlong sprinted like the wind, walking back and forth in the spacious laboratory, unable to stop with excitement.

Tang Que was still calm, with his hands crossed over his chest, staring at the white medicine, with a faint fire burning in his eyes.

After a month of sleepless hard work, they finally reverse-analyzed the synthesis method of the drug, and continued to optimize it, and finally synthesized this new drug.

Wei Kang looked at the detailed data in his hand and nodded with satisfaction.

"It's great. Not only have you perfectly synthesized this drug, but you have also optimized its lipophilicity, giving it faster and better results."

The blood-brain barrier refers to the barrier formed by the walls of brain capillaries and glial cells, which can prevent certain harmful substances from entering the brain tissue from the blood.

The solutes in the blood enter the brain tissue from the endothelial cells of the brain capillaries, which is difficult or easy; some pass through quickly, some slowly, and some cannot pass through at all. The endothelial cell membrane is lipophilic, allowing fat-soluble substances to pass through easily. Therefore, the more fat-soluble solutes in the blood pass through the barrier and enter the brain tissue faster.

Chen Yiqing and the others took advantage of this rule to modify the drug so that it can pass through the blood-brain barrier more easily and reach the patient's brain faster, thereby rapidly producing curative effect.

The drug molecule given by Weikang before did not have such lipophilicity, and they were able to make changes independently, which shows that they have fully understood the characteristics and structure of this drug molecule.

Chen Yiqing coughed lightly, and skillfully explained the follow-up work arrangement.

"The next step is safety and toxicity testing. I have already arranged manpower to conduct animal experiments. At the beginning, I will use white mice and rabbits to record the results of the experimental group and the control group, and then analyze them based on the control results."

"When the first phase of small animal experiments is completed, a round of controlled experiments will continue with medium-sized animals such as monkeys."

"After the animal experiments are completed and no toxic effects are confirmed, you can apply to the Food and Drug Administration for clinical trials."

"Phase I clinical trials observe the human body's tolerance to new drugs, formulate dosing regimens, and phase II clinical trials evaluate the therapeutic effect and safety of drugs on patients, and determine the dosage for follow-up clinical trials."

"At this point, it's almost time to really determine the success of the drug."

"Let's wait and see!" Chen Yiqing, who has always been mature and prudent, couldn't help imitating Wen Renlong by raising his fist and waving it in the air.

A burst of crisp applause rang out in the laboratory.

Another month passed, Wei Kang looked at the experimental report and the drug regimen in his hand, and nodded secretly.

Because he didn't directly use the systematic prescription, but insisted on letting Chen Yiqing and the others reverse the synthesis method, although it took two more months, it was worthwhile, and his chemists got a great deal. The growth has also gained a wealth of experience, which is of great benefit to the development of other new drugs.

"Very good, the inhibitory effect on γ-secretase is obvious. After taking it in the early stage, the amyloid protein in the body was significantly reduced, and the condition was greatly improved. There was no memory loss, and basically returned to normal."

"And there are very few side effects, and it has no effect on patients with diabetes and high blood pressure. The load on metabolic organs such as the liver and kidneys is not large, and it will not increase the physical burden of the elderly. This alone is better than other drugs of the same type. Know how many times."

"However, this drug is not as effective as an anticancer drug. After all, aging is an irreversible process. As long as you are old enough, the amyloid protein in the brain will continue to precipitate, and Alzheimer's disease is almost inevitable."

"It seems that the only way to suppress and delay the onset of Alzheimer's disease is to take medicine all the time. It can only be said that the effect is obvious for early stage patients. But for middle and late stage patients, the brain has shrunk. Even if the protein deposition is eliminated, their neuron cells It’s also very difficult to grow back.”

"Unfortunately, it seems that if we want to cure the root cause, we can only develop a drug that stimulates the regeneration of brain cells. This kind of drug is not easy to find. This involves the essence of aging, and the research on this aspect in the human scientific community is still very rough."

"No matter what, it should be enough to treat the early Alzheimer's disease of the old academician of aerospace. As long as he continues to take it, it will be able to delay the development of Alzheimer's symptoms with a high probability."

He then picked up his mobile phone and told Academician Qi the good news.

"What? You developed a new drug in two months?"

Academician Qi was basking in the sun and drinking tea in his study. Hearing this, his hands trembled, and the whole cup of tea fell to the ground, but he didn't realize it. He stood up suddenly and shouted loudly: "Quick! Arrange a car for me, I will Go to a nursing home."

Xishi Aerospace Sanatorium is located by a beautiful lake, with its back to the mountain and its face to the lake. It is built on the hillside. The natural environment is unique. The whole courtyard is full of bamboo and forest, very elegant and quiet, very suitable for the elderly to recuperate.

In a small building by the lake, the doctor shook his head insignificantly after examining the body of a gray-haired old man.

"Mr. Xie, after the inspection, you still need to rest more."

Lying on the bed, the old man slowly opened his eyes, looked at the doctor in front of him, and was a little dazed for a moment: "Who are you? Where are you? Why am I here?"

He immediately fell into deep thought, but his expression became more and more confused: "Aren't I in the research institute?"

Suddenly, he seemed to think of something, got out of bed suddenly, and was about to walk towards the door, his expression became extremely anxious in an instant.

"The rocket will be launched tomorrow, and I must be on the scene of the manned spacecraft this time. This year's mission is very important, and the space station will go to the sky in two months..." He muttered to himself as he walked, as if he was Read the work schedule.

The doctor hurried forward to support him, and persuaded with a smile: "Mr. Xie, you fell ill while working, and the leader told you to take a good rest in the nursing home so that you can recover as soon as possible and make more contributions to the future aerospace industry." Contribution. You can take a rest first."

Mr. Xie shook his head: "No, the launch mission this time must be completed on time. There were some problems that were not resolved last time. I have to go to the site to have a look."

The doctor sighed: "Mr. Xie, when you were not there, the rocket had actually launched. You must take good care of your body. Your body is the biggest asset. You can only return to work if you recover as soon as possible. This is the reason you Should understand."

Mr. Xie froze, turned around numbly, and lay back on the bed again: "The rocket was launched? It was launched when I was away? Hey, well, I'm already confused anyway, so I can't do much when I go back. It's better to stay here."

The doctor continued to comfort the old man, shook his head, and walked out of the ward.

Several people were waiting outside the door, all of them were family members and staff members, and they looked at the doctor one after another.

The doctor continued to shake his head: "Mr. Xie's condition is still the same, with ups and downs. Just now he was still talking about going to the rocket launch site, and he also said that the space station will go to the sky in two months. In fact, you and I both know that the space station died half a year ago. Heaven."

"This state is definitely not working properly. Now he can't even distinguish the time and place. If it continues to develop, it is very likely that even you and I will not be able to recognize him."

"I still recommend resting here. His condition can only be delayed, and it is impossible to cure him. Moreover, he also has high blood pressure, and his kidney function is not very good. Many side effects cannot be used at all, otherwise the consequences will be disastrous."

Several people all looked disappointed. They all had hope for Mr. Xie's condition, and hoped that this respected old man could return to work as soon as possible.

Unfortunately, there has been no progress in the disease, but it has become more and more serious.

Even if Mr. Xie can't go back to work, they don't want the old man to get this kind of disease. It's too cruel for a scientist.

This is an old man who dedicated his life to the aerospace industry of the motherland.

Admirable and admirable, even when he is sick, when he is awake, he always thinks about work.

The family members suddenly covered their faces and couldn't help sobbing.

Everyone looked at me and I looked at you, and shook their heads, with grief in their eyes.

How much they hope that there will be special drugs for the treatment of Alzheimer's disease at home and abroad. They don't seek a complete cure. The old people also live well.

It's a pity that after so many years of research at home and abroad, no medicine that can significantly improve the disease can be found.

Thank you, I'm sorry, there's really nothing we can do!

Everyone sighed in unison.

At this moment, a loud voice suddenly came from afar.

There was joy in the voice.

"Quick, tell old man Xie, his illness is cured!"

There will be another chapter later.