I can extract side effects

Kunming, First People's Hospital.

Another patient infected with multidrug-resistant Acinetobacter baumannii was completely cured by the antibiotics carried by nano-pills, and was transferred from the ICU to the general ward.

The foreign experts who watched the whole treatment process couldn't help applauding.

Back in the conference room, Dr. Harrison flipped through the medical records of all the clinical trial patients, and exclaimed in admiration.

"In just one week, we have seen no less than 20 patients who were saved by nano-pills. It is a miracle."

Others were also amazed and talked a lot.

"That's right, a patient with such a serious infection is helpless even in Cleveland."

"Many advanced antibiotics are more or less toxic, causing damage to liver and kidney functions. Patients already have signs of organ failure. If there are no nano-pills, I would not dare to prescribe vancomycin and polymyxin. drug."

"When it comes to life and death, it may still be used, but it is really hard to say whether the dose will save people or kill people."

"With nanopills, I can safely prescribe advanced antibiotics in the future."

"The commonly used penicillin and cephalosporins are quite safe, but unfortunately they don't work against superbugs."

Dr. Hanke, director of the Department of Infectious Diseases, was deeply touched by this, and said with a sigh: "Nano-pills can delay the emergence of drug resistance, but it will be a matter of time before we enter the post-antibiotic era. "

Dr. Harrison was surprised: "Is the matter already so serious?"

Hanke nodded affirmatively: "Antibiotic resistance is already a global problem. And it is still spreading and worsening. Hundreds of thousands of people die from drug-resistant infections every year, especially in low- and middle-income countries."

"It's a silent pandemic."

"If there are no effective new antibiotics in the future, more people will die from superbugs."

Someone asked worriedly: "Then is there any solution?"

Hanke explained: "There are two main ways to solve antibiotic resistance, one is to develop new antibiotics to replace the defunct antibiotics, and the other is to manage and use existing antibiotics more wisely."

"The latter can only be used as a mitigation measure and cannot be cured. The most fundamental solution is still to develop new antibiotics."

"But the biggest problem at present is that no pharmaceutical companies are willing to develop new antibiotics, leading to the gradual drying up of the antibiotic market."

"Compared with other medicines, antibiotics are extremely costly and very low returns, making pharmaceutical companies prohibitive."

"Pharmaceutical giants Sanofi, Novartis, AstraZeneca, Roche, Bristol-Myers Squibb, etc. have all exited the antibiotic market and moved into more lucrative areas. Pfizer, although still producing antimicrobial drugs, closed ten years ago. Antibiotic labs, even Johnson \u0026 Johnson, the largest pharmaceutical company in the world, don’t make antibiotics anymore.”

"The withdrawal of large pharmaceutical companies, which can provide extensive manufacturing infrastructure and global distribution capabilities, are critical to the antibiotic ecosystem, leaves uncertainty about the future of the antibiotic market, while taking away key human and infrastructure resources , leaving only a few small and medium-sized enterprises engaged in antibiotic research.”

"Maybe Bayer, Merck and other pharmaceutical giants are still developing antibiotics. I don't know how long they can last."

"The root cause is that it's hard to discover new antibiotics, and all the antibiotics that are currently on pharmacy shelves are derivatives of previous antibiotics that use limited methods to attack pathogens. Bacteria have become accustomed to it and have evolved new ways to fight it , while humanity has remained stagnant.”

"Since 2000, only two new antibiotic drugs, linezolid and daptomycin, have been approved."

"Not only have pharmaceutical companies not discovered new antibiotics, but the number of original antibiotics has also been decreasing. A total of 155 antibiotics have been marketed over the years, but due to drug resistance, toxicity and replacement by new-generation derivatives, only 96 antibiotics are currently available. "

"From sulfonamides to penicillin, streptomycin, and broad-spectrum antibiotics, after each successful discovery of a new effective drug, sometimes only a few months later, the bacteria re-emerge resistant and reemerge. Come."

"Bacteria are so adaptable that, by their very nature, humans will never be able to completely eradicate them."

"This is a war doomed to failure. The discovery of penicillin was once hailed as a miracle, but it is likely that in the near future, people will be helpless in the face of bacterial infections again as they were a hundred years ago."

Dr. Hank sighed, his expression becoming sullen.

However, he quickly cheered up and said.

"Of course, some people are developing new antibiotics, but the molecules of these antibacterial drugs are the same as polymyxin, which is very toxic to the human body, so their uses are limited, but with nano-pills, their toxicity can be greatly reduced , making them useful."

"This is also the great significance of nano-pills. Although we will eventually lose this war, at least we can lose it slowly."

Hearing these words, everyone looked at each other in blank dismay, and the atmosphere in the conference room became a little depressed for a moment.

Dr. Harrison frowned and said, "Hank, you are too pessimistic. Human technology is also constantly developing. We have excellent pharmaceutical companies that can continuously develop new weapons against bacteria."

Hanke smiled bitterly: "I hope so. Maybe I have seen too many tragedies clinically, so I can't help being a little pessimistic."

Dr. Roman spread his hands and said with a smile: "I must remind you that human beings are more tenacious than bacterial pathogens. In this endless war, I firmly believe that human beings will surely win the final victory."

Others chimed in: "Yes, the adaptability of scientists is invincible."

Hank nodded: "Although I think it is impossible for human beings to have the last laugh, this glimmer of hope does exist."

"The war between humans and bacteria has lasted for thousands of years. When broad-spectrum antibiotics were discovered, they had already won once."

"I have no doubt that there will be a second, a third victory."

Dr. Harrison shook his head, interrupting Dr. Hank.

"Let time test everything. Let's focus now, look at these medical records, and talk about what we have learned during this period."

The director of the hematology department showed excitement and raised his hands impatiently.

"Wow, artificial blood is the real miracle, you know? This thing is exactly like real human blood."

Dr. Roman joked: "It was originally derived from the differentiation of human cells. Could it be that it is still made of pig blood?"

"Hehe, I don't understand this. From somatic cells to iPS pluripotent stem cells, then to hematopoietic stem cells, and then to blood, there are so many steps, and there are infinite possibilities in between. If there is a little mistake, it is impossible to create a real blood."

"Sanqing has such stem cell technology. In a few years, I don't dare to think what else it can produce."

Dr. Harrison's expression became solemn: "Artificial blood is also an organ of the human body. It is not impossible if it can be expanded from small to large, from blood to blood vessels to a regenerative liver and even other internal organs."

Dr. Charlie chuckled and said, "I really want to see them create an artificial heart, a real heart that can beat and survive in the body for a long time, instead of a pig's heart that can only be used for one or two months."

Dr. Roman spread his hands again: "Maybe it's really possible. If you want me to say, I'm still the most optimistic about Sanqing, the most promising company in the world to research artificial organs."

"I am looking forward to the day when iPS stem cells can differentiate into nerve cells, instead of injecting stem cells into the brain like some quack doctors now, creating a bunch of tumors, and asking me to wipe their asses."

Harrison smiled knowingly, and interjected: "The young female doctor who asked you the question, how is her technique?"

Dr. Roman said sternly: "Dr. Jane's technique is very good. The most rare thing is her hand. During the five or six hours of surgery, it was as hard and stable as a rock. It is really rare. This is the most important thing in neurosurgery. talent."

"Dean, I strongly recommend that you lure her to Cleveland, if she chooses."

Harrison laughed: "Haha, you are so humorous, I bet this Dr. Jane's husband would not agree, by the way, do you know who her husband is?"

The corners of Roman's mouth curled up, with a hint of playfulness in his expression, and he asked, "Oh, did she marry the director of a hospital? That's right, given her excellence, her husband must not be an ordinary person."

"Hehe, she is the proprietress of the Sanqing Group." Harrison ignored Roman's joke and said with a serious face.

Roman was stunned for a moment, with an expression of disbelief, and asked, "That Mr. Wei?"

Dr. Harrison nodded, a sly smile on his face.

"So you understand why I insist on coming to this hospital in Kunming to study and communicate."

Everyone suddenly realized, and praised: "The dean is wise."

"So that's the case, then we will naturally cooperate with this hospital and come to study frequently in the future."

"Hehe, I thought of that too." Harrison took out a document in Chinese and English from his bag, put it on the table, and said.

"I have reached an in-depth cooperation agreement with Dean Fang. In the future, two batches of doctors will be sent over every year to participate in Sanqing's clinical trials and learn the most advanced medical technology."

The directors were surprised and delighted at once: "Great, there are many young doctors in my department, and such an opportunity is very much needed."

Cleveland is mainly here to take the lead in the investigation this time, so all the directors of the department are present to express their sincerity, and it is impossible to send all the directors here later.

If a long-term cooperative relationship is reached, the backbone and young doctors from the various departments of the hospital will definitely be sent over, so as to maintain a virtuous circle.

Dr. Roman was overjoyed, and said: "Dean, in fact, I was just about to tell you that according to my observations this week, Huaxia's hospitals have admitted a lot of patients, so there are also many difficult and miscellaneous diseases, and the treatment plan is very difficult, almost It is the best in the world, and in such an environment, doctors' skills will improve by leaps and bounds in a short period of time."

"Different from Yingguo's hospital, Huaxia's hospital also encourages doctors in the departments to study and study in subdivided fields and accumulate clinical experience, so that they will have a better overall view and have a deeper and more comprehensive understanding of the most sophisticated instrument of the human body. It is more handy when dealing with complex situations.”

"In this way, whether it is the treatment of patients with complex diseases or the professional growth of doctors, there are very obvious advantages."

"Doctors in Eagle Country, even in top hospitals like ours in Cleveland, only specialize in the treatment of one type or even one disease. From the pre-operative patient conversation, the formulation of the surgical plan, to the entire process of surgical execution, the doctors show great Highly proficient in process-based operation capabilities, only one focal point in the chain, and maximize work efficiency."

"But high efficiency means cost reduction, but it is precisely because of this high degree of specialization that our doctors know little about other subdivisions of their specialty, and most of them only specialize in one category or even one disease. treat."

"From this point of view, we can learn from each other's strengths and send young doctors to learn the overall situation of Huaxia Hospital and the treatment of complex diseases. They will definitely get enough training and make rapid progress."

The director of the urology department nodded in empathy: "That's right, do you still remember the Dr. Corey in my department? He only did stone surgery in his life."

The other directors all laughed out loud.

Roman covered his stomach and laughed for a while, before asking: "I remember that he is a urologist invited by Dean Harrison, and he can only perform surgery for urinary tract stones, but he is very good at minimally invasive surgery. Why didn't the dean renew the contract?"

Director Harrison's face darkened, and he said with a straight face: "You remember wrongly, that is an expert invited by the former dean, it has nothing to do with me, after extracorporeal shock wave lithotripsy became the first choice for the treatment of kidney stones, surgery became more and more serious. If not, I won't keep him any longer."

Roman smiled awkwardly: "That may be because I remembered wrongly." He lowered his head and focused on looking at the medical records.

Time passed quickly, and soon it was time to leave.

In a short period of time, the experts at the Cleveland Clinic have formed a deep friendship with various departments, and the relationship is very harmonious, laying the foundation for subsequent cooperation.

Dr. Harrison was not idle either. As the dean, he didn't need to see a doctor for surgery, so he was either in meetings or running outside all day long.

Not only did he negotiate a long-term cooperation agreement with Dean Fang, but he also became familiar with the Health Commission of Kunming City and Jiangsu Province, and even discussed the exchange and cooperation project between the two parties as a major achievement of the Suzhou Health Commission. There was a lot of coverage in the media.

The consultations and operations performed by foreign experts have also established the reputation of Kunming First People's Hospital.

After the reputation spread, even patients in Haishi bought scalpers' tickets to come to Kunshi to see a doctor.

For a while, it can be said that he stole the limelight.

In particular, the hospital announced the cooperation agreement, stating that joint consultations and surgeries by foreign experts will be held regularly in the future.

The patients were so excited that they already regarded Kunming People's Hospital as one of the best hospitals in China.

After all, the directors of the world's top hospitals came out in full force, and it is too rare to come to Huaxia Hospital for consultation.

In the past, there were only one or two foreign experts at a time, and they basically came and went, opened throwing knives, shot a shot to change places, and rarely stayed in one place.

Therefore, when Harrison and his party left, Academician Fang was also a little bit reluctant.

This time, the pie from the sky not only earned a wave of performance, but also took the opportunity to ask for a large sum of money from above.

Therefore, he held a grand farewell party very generously, and personally sent the group of foreign guests to the plane.