I can extract side effects

Wei Kang was taken aback when he received a call from Sun Chengren.

"What? You went back to your hometown and had a drink, and the whole family was infected with Helicobacter pylori?"

"Have you been diagnosed with gastric ulcer? I'll go. I know that the rate of bacterial infection is very high, but I didn't expect it to be so high."

"Okay, no problem, the three of you can apply on the Longtu APP, and it should be no problem to join the Phase III clinical trial."

"Our spiramycin has a very good bactericidal effect. It is a narrow-spectrum antibiotic that only inhibits Helicobacter pylori. Unlike amoxicillin, a broad-spectrum antibiotic, it can damage the intestinal flora and affect the digestive tract. healthy."

Sun Chengren was very happy when he heard this: "That's great. I heard that the quadruple drug has strong side effects, so I don't want to take that. I haven't thought about the intestinal flora. If this is the case, of course it is our own research and development. The medicine works well."

Wei Kang reminded: "However, if you participate in the experiment, you may be assigned to the control group. You'd better be mentally prepared."

"It's okay, I understand. Besides, I don't think my luck is that bad, haha." Sun Chengren said nonchalantly.

He suddenly became a little curious, and asked: "Xiaokang, you spent the New Year at Jane's house? How do you feel?"

Wei Kang faltered instantly: "That's it. I had a New Year's Eve dinner and stayed for two days. I returned to the company in the second day of junior high school. Their attitude is very polite, so I should be satisfied."

Sun Chengren chuckled: "Who can be dissatisfied with a son-in-law like you? Seeing that you are developing so smoothly, I am relieved."

"By the way, when you get engaged later, you have to go back to your hometown in Gan Province to recognize your relatives. Although the grandparents are gone, there are still some uncles and uncles. You must notify when you get married."

Wei Kang was silent for a while, then said calmly, "Got it."

After hanging up the phone, he couldn't help but think of some past events.

My father's hometown is in Yushan County, Jiangxi Province. He came out to work early, and after saving his family fortune, he started a pharmaceutical company.

Because the Sanqing Mountain in my hometown is famous for its beautiful scenery, it was named after Sanqing. As for my mother, she was married out, and it is said that she has a bad relationship with her natal family, so she seldom goes back.

He grew up in Kunming City since he was a child. His parents are busy with work. He only goes back to his hometown to visit relatives during the Chinese New Year. He rarely goes back, so he seldom deals with relatives in his hometown. name.

Later, grandparents, grandparents and grandparents all passed away one after another, parents also left, and all immediate family members disappeared.

Only the uncles on my father's side are left, who will contact me occasionally and join the family WeChat group.

Whenever there are festivals, he will throw red envelopes wildly in the group, other than that, he has nothing to do.

He still has a good impression of his father's relatives. Knowing that he is so rich, he didn't come to borrow money to play the autumn wind, which shows that he has a good character and is worth visiting.

As for the relatives on the mother's side, he has no contact with them for a long time, and he has no impression of relatives other than his grandparents.

I vaguely heard from my mother that her natal family seemed to favor sons over daughters and treated her poorly. Later, when she saw that she was married well, she always found various reasons to borrow money, and often had eccentricities, so after her grandparents left, they immediately severed the relationship.

Therefore, Wei Kang didn't even have a contact method for the relatives on the mother's side. He also made up his mind that if he got married in the future, he would only invite relatives from his father's side.

In fact, based on his original intention, he didn't really want to go back to his hometown, mainly because he was too lazy to move, but for such a big event as marriage, it would be unreasonable not to go back to his hometown.

According to traditional customs, when a newcomer is added to the family, he has to visit the graves of his grandparents and pay respects to the ancestors, so as to comfort the spirits of the elders in heaven, and take his wife to meet relatives by the way. He has to go there himself.

"Hey, these family affairs are really troublesome. It's a good thing to get married this time, otherwise it would be too annoying."

Wei Kang pinched the center of his brows and couldn't help sighing.

He really missed the days when his parents were still there, and he never had to worry about these trivial matters.

But now that he is the figure of the old Wei family's Guangzong Yaozu, these trifles of welcome and delivery will probably be indispensable in the future.

*****

Sun Xiaoshi opened the address book, searched it from beginning to end, and finally found Gao Yuan's WeChat account among the new friends.

At that time, after the wedding banquet was added, the two hadn't chatted much, so she had no impression of this account.

"Now I remember you." Sun Xiaoshi thought bitterly, labeling him as 'bad breath boy'.

She pondered for a long time before sending a message.

"Hello, I'm Sun Xiaoshi who sat next to you at the wedding banquet. After we came back, the family went to the hospital for an examination and found that they were infected with Helicobacter pylori. It may have been obtained from a dinner in my hometown, so I would like to remind you kindly and do a test as soon as possible. examine."

As soon as the message was sent, there was a reply in seconds.

"What the hell?"

Immediately afterwards, messages came one after another, like a cannonball.

"Did you infect me?"

"No wonder I have been feeling sick to my stomach since I came back. It turns out that I got infected after eating with you."

"You wait, I will go to the hospital for an examination tomorrow, if something really happens, I can't spare you."

"???" Sun Xiaoshi was stunned for a moment, her liver ached from the other party's slapping behavior.

She took a deep breath, suppressed the anger in her heart, and replied, "Don't spitting blood at others, whoever is infected may not know."

"I always remind you with good intentions. If you don't believe me, you can get it. I wish you good luck!"

After speaking, he threw away the phone and ran to complain angrily.

When Sun Chengren heard about this, he was also a little displeased: "Forget what this man said, anyway, he has been notified anyway, even if he really has a stomach problem, it's none of our business."

Soon, Sun Chengren applied for the clinical quota of spiramycin, and took his family to the hospital again.

It's just that this time he came to test the drug. After some inspections, he was randomly assigned to the positive drug control group, and he will take the marketed quadruple drug for comparison.

The daughter and wife were assigned to Sanqing's drug group.

Sun Chengren couldn't help but smiled wryly. He thought he could avoid the torment of the quadruple medicine and use Sanqing's new medicine directly, but he never expected to go around and come back again. It's really bad luck.

"It's okay, after the control experiment is over, I will give me pylorimycin." He comforted himself in this way, and swallowed the pill as soon as he raised his head.

It didn't take long for him to feel a headache. As soon as he lay down on the bed, he felt sick and a metallic taste came out of his mouth.

"Damn it, my luck is really bad." Sun Chengren looked at his wife and daughter in high spirits, couldn't help feeling depressed for a while, and immediately closed his eyes angrily.

When eating, he still had a metallic taste in his mouth, and nothing tasted good, and there was no taste at all.

And because he took too much medicine, he was half full after eating, which made him lose his appetite to eat.

A few days later, Sun Chengren visibly lost weight. He couldn't eat or sleep every day, and his spirit was extremely haggard.

Both his wife and Sun Xiaoshi realized that something was wrong with him, and they were all in a hurry.

"Dad, why did you become like this? Why are the adverse reactions so severe?" Sun Xiaoshi was not idle during this time, and probably learned some knowledge about clinical trials, knowing that this is a manifestation of side effects.

Sun Chengren was lying on the bed, squinting his eyes, and said weakly: "Hey, it's enough to survive a cycle, anyway, it's all about curing diseases, as long as it can be cured, any adverse reactions are not important, the result is important .”

The wife couldn't help but complained: "It seems that the medicine you took is not good. Look at the medicine that Xiaoshi and I took, there is no reaction, just a little acid regurgitation for the first two days, and then it's all right. I don't have any pain here. Now, it feels like nothing happened."

"If I had known earlier, I would have changed with you. Anyway, I am young and recover quickly. It's okay to be uncomfortable, and I can still lose weight. You are already old, and you must not be able to bear it."

Seeing her father's miserable state, Sun Xiaoshi couldn't help shaking her head.

Sun Chengren let out a long sigh, and began to close his eyes to meditate pitifully and helplessly.

The experiment of a course of treatment ended soon, and the doctor began to test the effect of the treatment on the three of them.

After taking the C-13 test, Sun Chengren asked anxiously: "It should be cured, I feel that the effect of this medicine is quite strong, and it directly knocked me down."

The doctor looked at the test results and couldn't help frowning: "Well, the metronidazole you took has developed drug resistance. Although the treatment has a certain effect, it has not been completely cured, and remedial treatment may be necessary."

"What?" Sun Chengren was stunned for a moment, and couldn't believe his ears.

He suffered for a week and lost a full ten pounds, and this is the result?

It is unacceptable.

He couldn't help trembling: "What remedial treatment?"

The doctor did not raise his head, and replied while thinking: "You are already resistant to metronidazole. If you use salvage treatment, you have to increase the dose to overcome the drug resistance, but the curative effect has improved, and the adverse reaction rate has also decreased." will increase accordingly.”

"Either change to an antibiotic that is not resistant, such as furazolidone, but the adverse reactions of this drug are quite high. Considering your age, it may be more painful, and it may not be bearable."

Sun Chengren shuddered for a moment and almost cried.

"Doctor, is it okay if I don't take this medicine? No, I don't want to just treat it. Can you just give me that new medicine from Sanqing? I beg you, my old bones, take a look I can't bear to be tossed like this."

The doctor looked up at him, nodded and said, "Indeed, if you were young, I might continue to give you remedial treatment, but if you are already like this, it would be inhumane to continue."

He waved his hand and said: "Okay, you can end the clinical trial, we will give you Sanqing's antibiotics for treatment."

Sun Chengren was overjoyed and thanked repeatedly.

The test results of his wife and Sun Xiaoshi also came out, and the new drug worked very well. After a week of treatment, the Helicobacter pylori in their bodies was completely eliminated.

The two breathed a sigh of relief and walked away with smiles on their faces.

Before leaving, Sun Xiaoshi comforted her father and said: "Dad, don't worry, you can see how good my effect is, just eat for a few days and everything will be fine. There is nothing wrong with you. You must be the same. Mom and I will wait for your healthy return at home. "

Sun Chengren was also refreshed, full of anticipation for the next drug test results.

Soon, he was led aside by the nurse and swallowed a white pill.

Although high-dose quadruple broad-spectrum antibiotics can kill Helicobacter pylori, it also pays a heavy price for the body.

That is a thorough reshuffle of the microbial environment in the body. All the bacteria, good or bad, are all eliminated, which is equivalent to reshuffling the talent.

However, after the body is washed with talent, the bacteria are also washed, and there are always some drug-resistant bacteria that are screened out to become survivors. If they are good drug-resistant bacteria, then congratulations to the patient with a high probability of recovering as before the course of treatment. It should be better.

If the bad drug-resistant bacteria survive, or the Helicobacter pylori itself produces drug-resistant bacteria, then the patient will most likely have to have another antibiotic storm. If a vicious circle is formed, it means that the body has played GG.

Faced with such a bacteria that has coexisted with humans for many years and has evolved so tenaciously, the best treatment plan is to use targeted narrow-spectrum antibiotics to avoid damage to other flora in the body, so as not to disrupt the normal microbial balance of the human body.

Therefore, only Sanqing's spiramycin pylori is the real effective medicine for the symptoms.

After Sun Chengren took the medicine this time, he felt very good. Except for a little nausea and acid reflux, there was nothing uncomfortable at all.

Compared with the previous adverse reactions, this is nothing at all, it is a piece of cake.

At lunch, his mouth no longer had that uncomfortable metallic taste, and his appetite improved a lot. In addition, after being hungry for so long, he drools when he smelled the smell of food. He ate a big bowl of rice, satisfied Hiccup.

"Great. Sure enough, when it comes to new drug research and development, which one is better, it depends on our Sanqing."

While picking his teeth, Sun Chengren thought complacently.

If it weren't for the large number of damn germs that caused his stomach troubles to be so severe, he would rather wait until the new drug came out and buy it directly than take the damn quadruple antibiotics.

He always heard that patients would have all kinds of adverse reactions after taking the medicine. He used to sneer at this, thinking that the patient was too hypocritical, and it was good to cure the disease. What's wrong with it? Can it be compared with life?

Unexpectedly, now I finally tasted the bitter fruit, and instantly understood what was going on with this painful side effect.

Sure enough, if it didn't happen to me, I wouldn't know how uncomfortable it was.

As the saying goes, if you compare people, you will die, if you compare goods, you will throw them away.

After taking Sanqing's medicine, he could no longer bear the adverse reactions of other medicines.

He swore right away that if he got sick in the future, he would only take the medicine from his own company.

If there is no such drug, the company will be forced to develop it as soon as possible.

Anyway, don't let him suffer any more.

Next, after taking the medicine for five days, when he checked again, he found that the Helicobacter pylori in his body had been completely eliminated.

Although the previous quadruple antibiotic treatment produced drug resistance and the effect was mediocre, it also played a certain inhibitory effect.

Coupled with Sanqing's special antibiotics, the two-pronged approach, the original serious bacterial infection was quickly cured.

Then there is the problem of treating gastric ulcers.

After the main cause is removed, I believe that as long as I take the medicine step by step, I will recover completely soon.

Sun Chengren happily left the clinical building, turned around and entered the outpatient building.

I found the doctor and prescribed some medicine for gastric ulcer, and I went home immediately.

He has already fully realized the power of this new narrow-spectrum antibiotic.

It is foreseeable that when the new drug is launched, it will definitely set off a storm and cause a sensation.