I can extract side effects

Liu Yurong was the name of Granny Liu when she was young, and now she is 72 years old.

When she was young, she joined the army. Although she is thin and small, she has a straight back and strong eyes. She is a heroic female soldier.

As she gets older, especially after the age of 65, she often suffers from dull pains in her lower back, and often cramps in her calves at night. Once it occurs, the pain lasts for more than ten minutes and requires a long massage to relieve it, which especially affects sleep.

Her back was no longer straight, but bent down, and she always walked with her head down, and her movements were slow, but she could still move freely.

All along, she thought this was a normal phenomenon when people got old, and she didn't pay much attention to it.

Until one time, when she was packing old boxes at home, her legs suddenly weakened, she slipped and fell to the ground, and her back hit the wall hard.

In an instant, there was a sharp pain in her lower back. At that time, she sat on the ground for half an hour before she could get up.

The pain in the lower back has intensified since then, and it lasted for 2 weeks before it gradually eased.

Since her children are all working in other places, she usually lives alone at home in order not to worry her children, so she did not go to the hospital for examination.

In fact, she also felt that, but she just fell and bumped her waist, so it wasn't a big problem.

This kind of pain, she experienced a lot when she was young, and she really didn't even frown.

But in the following years, the pain in her lower back became more and more frequent, and the pain often made her unable to straighten her back.

So she simply kept bending over, and even used a cane.

Slowly, her back became more and more pronounced.

Granny Liu thought that "it is common for old people to bend over", so she gradually accepted her hunchbacked life.

It wasn't until the daughter, who hadn't seen each other for two years, went home to visit relatives that she was surprised to find that her mother had a hunchback, and the hunchback was so serious that her daily life was obviously affected.

Forced by her daughter, Grandma Liu finally went to Kunming First People's Hospital on crutches.

At this time, her entire back had been bent into a very unnatural hemispherical shape, and her hunchback was extremely obvious.

The spine of the whole person is like a curled shrimp. Only by holding the cane tightly to the chest with both hands can the body be stabilized.

The lower back was pressed so low that it was almost impossible to look straight ahead, and could only look down at the ground.

Granny Liu walked into the consulting room very slowly like a snail that was oppressed by its heavy back shell.

The daughter stood beside her, supporting her like an old and frail camel.

At a glance, people can only see the towering hump, but they cannot meet her eyes.

This scene left a deep impression on the doctors who were seeing the doctor at that time.

As an orthopedic surgeon, he has seen many patients like this, but even he has rarely seen such severe osteoporosis.

The doctor first evaluated Granny Liu's height change.

The results are astounding!

She was 158 cm tall when she was young, but now she is only 147 cm tall, and she has lost a full 11 cm in height.

After a series of examinations, Granny Liu's bone mineral density had reached -4.1, and she was diagnosed with severe osteoporosis. At the same time, her 7th and 8th thoracic vertebrae still had old compression fractures.

It was because of severe osteoporosis and compression fractures that stole her height, which led to her obvious hunchback.

After being hospitalized for a period of time, Granny Liu's pain improved.

Although the doctor also prescribed anti-osteoporosis drugs, at this age, considering the adverse reactions after taking the drugs, the choice of drugs is relatively limited.

The most commonly used treatment is bisphosphonates, but no matter what the treatment is, it cannot greatly restore the bone density, but it can only reduce the risk of fracture as much as possible, so that she can only maintain her current state and not continue to deteriorate.

That's actually enough.

Any treatment for osteoporosis is a long-term and lengthy process. In many cases, doctors can only help, and the final victory over the disease can only be achieved by yourself.

According to the usual practice, she was discharged after staying for two weeks, and every year when the pain was unbearable, she would stay for another two weeks, and so on.

When he was discharged from the hospital, the doctor couldn't help feeling a lot of emotion when he saw Grandma Liu bending over.

This kind of severe osteoporosis, in fact, there is no particularly effective way.

He knew that there was nothing he could do, he could only watch Grandma Liu's condition getting worse and worse.

Thinking of this, a deep sense of powerlessness surged in his heart, and he felt a trace of sadness and helplessness.

In fact, Grandma Liu’s best age to prevent osteoporosis is in her 30s, but if you go back 40 years, it was the 1980s.

For people in that era, the concept of osteoporosis was almost unknown.

This also determines that this generation has actually passed the best time.

This is why so many elderly people suffer from osteoporosis.

This is probably the price of time, the doctor shook his head and sighed in his heart.

Grandma Liu's daughter attaches great importance to her mother's condition, so she goes home to take care of her. She also downloads the most authoritative and popular Longtu APP to record cases and medication.

On a sunny winter day, a notification was sent to Granny Liu's daughter's mobile phone.

She immediately cheered: "Mom, Sanqing has released a medicine for treating osteoporosis, and now the quota for clinical phase III trials is open. I'll help you sign up."

Grandma Liu was sitting on a chair on the balcony, under the golden sunlight, she could only look at her feet in a daze.

"What experiment? What's the name?" She asked with a dull expression and some slurred words.

The daughter walked over with a smile, knelt down and said, "Just go to the hospital to take medicine, and I will take you there in a while. Sanqing's medicine is very effective, and this one will not disappoint."

"Oh." Granny Liu responded, but didn't speak again.

The daughter was very excited and kept talking: "This medicine is very powerful. The astronauts in the sky are taking it. They take it in the space station and on the earth. It must be effective. Otherwise, will the country allow them to take it? Mom , if you eat it, you will definitely get better."

Granny Liu suddenly grasped her hand tightly and said in a trembling voice, "Are all the astronauts eating? That should be very good. I believe in the country."

The daughter looked at her mother, only to see that her cloudy eyes lit up instantly, and there seemed to be a glimmer of hope in the numb eyes.

So he nodded quickly and said, "No mistake, it will definitely work well."

That afternoon, Granny Liu came to the hospital. After a physical examination, she signed the informed consent form.

She was assigned to the intensive care unit, in the same ward as a group of hunched old men and women.

The youngest of these people is 65.

There are menopause group, mild disease group, and even youth group next door, adding up to hundreds of people.

The menopausal group is a group of aunts, the mild group is a group of uncles, as for the youth group, there are also a lot of people. This disease is becoming more and more common among young people.

Their illnesses are all due to some bad living habits, such as not basking in the sun, lack of exercise, often drinking carbonated drinks, and eating junk food, which lead to calcium loss, vitamin D deficiency, and damage to bones.

The situation of each group is different, so the medicines taken are different.

Like the youth group, due to their prime of life and strong resilience, it is enough to supplement calcium and vitamin D with drugs.

As for the aunts and uncles, the aunts need to take sex hormone drugs, but the uncles don't, but take drugs that promote bone formation.

And this time, except for the severe group, other patients will participate in double-blind controlled trials.

Because there are many drugs for the treatment of osteoporosis on the market, it is necessary to conduct a comparative test with the first-line drugs already on the market.

The patients in the critically ill group are all older and have been treated for several years. They have taken all the medicines that should be taken. The existing medicines on the market have no effect, so the treatment plan should be more cautious.

This group of old men and women can't stand the toss, so naturally they don't need to participate in the double-blind experiment.

Granny Liu could only lie on her side on the hospital bed due to her deformed spine. Her whole body was in severe pain and she couldn't stop shaking.

Next, in addition to supplementing calcium, she took the new medicine of Sanqing every day.

In the first week, she didn't feel too obvious.

In the second week, it seemed that the bones of the whole body did not hurt so much, and the fatigue phenomenon also improved.

In the third week, the pain in the lower back was less severe.

In the fourth week, the test results showed that the bone density increased by 7%, reaching -3.8.

Although osteoporosis is still relatively serious, it has been suppressed and is developing in a good direction.

After another month, Grandma Liu's back pain has been greatly relieved, and the pain has become tolerable.

Her bone density has reached -3.4, an 18% increase in bone density compared to before, and the effect is immediate.

The daughter was holding her mother's withered hands in front of the hospital bed, crying with excitement.

"Mom, the anti-osteoporosis treatment is very successful, and the bone density has been improved. Next, as long as the deformed spine is surgically repaired, you will be able to straighten your waist and walk normally."

After two months of clinical trials, the effect is obvious. The mother's condition has been suppressed and is getting better.

Next, she will ask a doctor to perform spinal correction surgery on her mother.

The operation is very difficult and requires high technology and equipment hardware. At the same time, the trauma is large, the time is long, and there are certain risks.

However, the mother's bone density has improved now, and the sooner the operation is performed, the sooner she will be able to walk normally.

At that time, you only need to take medicine and long-term rehabilitation.

Under the guidance of the three-dimensional imaging CT system and the assistance of advanced surgical equipment such as ultrasonic bone knife and drill, the operation was carried out smoothly.

After the operation, Granny Liu's spine was corrected, and she could finally lie flat on the hospital bed comfortably.

Grandma turned her head with difficulty, looked at the surrounding scenery, and then looked at the ceiling.

Her eye sockets were moist.

After five years, I can finally look up at the sky and no longer have to stare at my feet.

As long as she continues to take this astronaut-certified medicine in the future, she will definitely recover completely.

In Granny Liu's gloomy eyes, the fire of hope for future life was rekindled.

There are many patients like Granny Liu who are slowly recovering.

At the end of the trial, the conditions of all the testers who participated in the drug were greatly improved.

*****

The clinical phase III trial report of the bone resorption inhibitor soon arrived at Weikang's hands.

He is very satisfied with the results. Even with the double-blind experiment, the data is still amazing.

Compared with the control drug, patients taking Sanqing bone resorption inhibitors had an increase in bone density of more than 20%, a 81% reduction in the risk of new vertebral fractures, a 62% reduction in the risk of non-vertebral fractures, and a 62% reduction in the risk of hip fractures. risk reduction of 73%.

In terms of adverse events, Sanqing’s new drugs are also less, and there are basically no serious adverse reactions.

Wei Kang couldn't help feeling in his heart that the medicines produced by the system are always so safe and effective.

Generally speaking, in addition to its own reasons, another important reason for the side effects of drugs is the excipients and impurities in the production process.

To achieve such a low adverse reaction, the purification technology of drug molecules must reach a very high level.

Wei Kang couldn't help being envious.

"Boom boom boom!"

Suddenly there was a knock on the door.

"Come in!" Wei Kang glanced at the schedule and remembered that this was a regular work meeting with Chen Yiqing.

Sure enough, Chen Yiqing quickly opened the door and entered, and sat opposite him.

"Mr. Wei, the recent schedule of scientific research projects in the neuroscience laboratory is as follows..."

Chen Yiqing clearly reported the progress of the laboratory's work, which made Wei Kang nod his head.

"Your laboratory has a new research goal, this time to study the regeneration of motor neurons."

Wei Kang looked at this new project curiously, and asked, "Have you discovered anything? Or is it just an idea?"

Chen Yiqing explained with a smile: "We have made a huge breakthrough in the research on the regeneration of brain neurons, but the human nervous system is not unique to the brain, and the nerves in the muscles are also very developed. This time I want to study the motor nerves. Yuan regeneration."

"Motor neurons, which connect the brain and muscles through the spinal cord, are very promising research objects and will be very useful for in-depth understanding of the human nervous system."

"As you know, motor neurone disease is also called gradual frostbite, which can cause muscle atrophy all over the body and difficulty swallowing, and finally die of respiratory failure. This disease is very famous and has always been a terminal illness, but in recent years, scientists have discovered It has identified a potential therapeutic target for the disease and provided some new ideas, which I want to try."

"However, this is just a new drug research and development project. I will continue to study the human brain. After all, the brain is my favorite."

Wei Kang was overjoyed immediately. As a boss, he was not afraid of his employees being too active, but he was afraid of their employees not being active.

It would be great for Lao Chen to take the initiative to explore new projects and enter new fields.

He immediately patted his chest and agreed: "No problem, what resources do you need, how much investment do you need, just tell me anytime."

"Okay, I will study this project with my assistant Zhang Li. She has great potential in neuroscience, and I am ready to train her well."

Chen Yiqing pondered for a moment, then mentioned another matter.

"That's right. The paper you published last time seems to be the second author. I'm very happy that you can find excellent talents for the company."

"Yes, she is already a team leader in the laboratory, a very talented little girl, maybe she can take over my class in the future."

"Sure, as long as she shows enough ability, she can become the director of the neuroscience laboratory in the future." Wei Kang chuckled.

After the meeting, Wei Kang clicked on a list from the computer.

The people on this list are all outstanding young employees who are worthy of the company's vigorous training.

He also put Zhang Li on the focus list.

A person who can be recommended by Chen Yiqing should be good enough to be worthy of attention.

After finishing the work, he looked at the desktop again, where there were clinical trial reports of several other new drugs.

Last time he extracted eight new drugs in one breath, and now their experimental results are all out.