I can extract side effects

Chapter 348 You should use this bone resorption inhibitor (Part 2)

Wei Kang also saw the news about NASA on the Internet, but he didn't take it seriously, he just thought it was a bit ridiculous.

He instantly had a feeling of eye-opening. It turned out that bureaucrats all over the world have similar faces when they cheat funds.

It is not news that many organizations in Eagle Country purchase Eastern equipment, directly remodel it, put on a compliant coat of appearance and brand, and use it blatantly.

Unexpectedly, NASA, which claims to be a temple of science and technology, has also fallen. It is no different from other agencies.

Thinking of this, he couldn't help shaking his head in disappointment. Compared with China Space Center, this NASA is simply too far behind. It can't even be realistic. .

At this moment, the phone rang suddenly.

At first glance, it was Fang Heng from the space center.

Fang Heng came this time to announce the good news: "President Wei, good news, the portable universal monitor is very successful, and the Aerospace Center wants to reach a long-term strategic partnership with Sanqing. Strengthen cooperation."

Wei Kang was very happy to hear that. This is really good news. In this way, if any medical device is developed in the future, it can be displayed and promoted directly on the space station. As far as Sanqing is concerned, the truth has a lot of benefits and no harm.

It’s not obvious when there is only one piece of equipment now. In the future, more medical equipment will be developed, especially some high-end large-scale equipment. It is much more powerful to try it in a place like a space station than in a hospital.

If the effect is good, it is equivalent to a layer of endorsement, and it will definitely be more convincing when it is promoted to other public hospitals in the future.

So they agreed immediately, and then, the two sides talked about in-depth cooperation in medicine.

Due to the influence of a series of factors such as strong radiation in space, weightless environment, and storage conditions, the efficacy of many drugs will drop significantly after traveling in space, and many drugs cannot meet the prescribed efficacy requirements.

Correspondingly, the shelf life has also been greatly shortened, generally 6-12 months, which is much shorter than the two to three years of ordinary drugs.

In the space station, the activity of many bacteria and viruses can often be greatly improved, and even mutated to a certain extent.

So the Aerospace Center wants to work with Sanqing on medical and genetic research.

Not only to extend the efficacy and shelf life of some common drugs, but also to use the space environment to study the genetic variation of organisms.

Sanqing Group has an excellent reputation in the manufacture and development of original drugs and generic drugs, and is the best partner to seek cooperation. Not to mention, many of these drugs are themselves produced by Sanqing.

As for the field of biology, brand-new gene editing technology and gene therapy are Sanqing's strengths.

"Due to the needs of space travel, such as a three-year trip to Mars, and the construction of a lunar base in the future, our current frequent supply mode for drugs is not realistic. The long-term demand for drugs must be taken into account and reach space as much as possible. self-sufficient.”

"Currently, the shelf life of most drugs on the market cannot meet the requirements of space travel, and on-demand drug production in space may be the best solution to this challenge."

"So we plan to start with some of the simplest drugs to study the impact of microgravity environment and space radiation on the stability of tablet formulations. Radiation protection will be incorporated into the design of the tablet."

Fang Heng talked eloquently, telling the whole plan of the space center.

"The first batch of drugs not only contained active ingredients such as ibuprofen and vitamin C, but also included excipients such as silicon dioxide, magnesium silicate and calcium phosphate, which can be found on the surface of the moon."

"Our plan is to change the interaction between the ingredients and the drug so that we can understand how these changes affect the drug's stability."

"If data on drug stability can be collected for long-duration space missions, it could help future on-demand drug production in orbit."

"This is an 'automated airborne pharmacy' project. It has just been approved and has not yet officially started. However, with your participation, it will be even more powerful and progress rapidly."

Wei Kang couldn't help but feel moved. The unique microgravity environment in the space station can make some scientific researches limited by the earth's gravity develop and make new breakthroughs.

This is also very important for the field of life sciences and biotechnology.

During the more than 20 years since the International Space Station was in orbit, a total of more than 3,000 scientific researches in various disciplines have been carried out, among which the biological sciences account for the highest proportion.

It's a pity that the former Huaxia was completely isolated in this research field.

There is neither a space station nor a pharmaceutical giant, and there is no condition to carry out research in the fields of space medicine and biology.

Now, with Sanqing Pharmaceutical and Tiangong Space Station, the conditions are very mature, and we can catch up and speed up the research in the field of life science in space.

Not only is the field of biology worth trying, but even individual star-level blockbuster new drugs also have contributions from space experiments.

Many macromolecular drugs face many technical difficulties in manufacturing, delivery and storage, which are expected to be solved by improving crystallization and purification technology.

Researchers at Merck, in collaboration with the International Space Station, have performed crystallization experiments with macromolecular drugs on commercial resupply service space missions.

They investigated the effect of sedimentation rate and temperature gradient on crystallization purification using microgravity experiments.

It was found that under microgravity conditions, sedimentation and convection were reduced, and the resulting crystalline suspension was less viscous and more homogeneous than a terrestrial control.

Later, the team successfully replicated a homogeneous crystalline suspension in space in ground experiments using rotating mixers to control variables such as sedimentation rates and temperature gradients to induce nucleation and control crystallization.

This is of great significance to the purification and storage of macromolecular drugs. If it is widely used, macromolecular drugs will be converted from intravenous injection to subcutaneous injection, which can greatly improve the quality of life of patients.

In addition, the space environment can also provide meaningful data for clinical trials and provide comparisons for trials on the ground, becoming a perfect reference.

Now, he has a ready-made new drug on hand, which is perfectly suitable for the physical problems caused by the space environment.

Thinking of this, Wei Kang glanced at the desktop and picked up an experiment report.

This is the first clinical trial report of bone resorption inhibitors.

Data show that this new drug can inhibit bone resorption and has a strong therapeutic effect on related diseases such as osteoporosis.

As for the disease of osteoporosis, no one has experienced it more deeply than astronauts.

In space, astronauts are exposed to microgravity conditions for a long time, and a series of changes will occur in the body, which will induce some potential diseases. The most prominent problem is osteoporosis.

Under normal circumstances, the bone maintains the balance of bone mass through the interaction of bone formation and bone resorption.

But in a microgravity environment, because the bones no longer have to resist the action of gravity, the reduced load leads to increased bone resorption, which leads to osteoporosis.

While physical activity can mitigate, it does not completely eliminate the risk.

The whole process is very fast, and it can often lead to osteoporosis in astronauts in a few weeks. Unlike on the ground, osteoporosis is rare in young people and more common in old people.

There is no doubt that a strong and resilient astronaut would be a very suitable tester.

The space environment is also the perfect place for clinical trials.

Healthy people will have symptoms of osteoporosis within a few weeks after going up, and they can test the efficacy of the medicine while taking medicine.

It can recover quickly after coming down, and there is no need to worry about sequelae.

Doesn't this beat old ladies in their 60s?

The moment this idea came up, Wei Kang said it directly to the phone.

He can be sure that the other party will definitely be interested.

"There is a new drug, a bone resorption inhibitor for osteoporosis, I think you should use it."

"I don't know if your astronauts are willing to try it?"

The 5,000-word chapter was blocked, and it took 48 hours to apply for unblocking, so it was split into two chapters and published.

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