I can extract side effects

Kunming, Sanqing Headquarters.

At this time, Wei Kang kept his ears to the outside world, and was in the genetic laboratory, paying attention to the latest work progress.

"These are ancient bacteria found in the 420,000-year-old ice on the Antarctic continent. We took them from the scientific expedition team. Many of them are still active and can grow in the laboratory as usual after being extracted. "

"The environment of the ice layer allows these bacteria to have a state of near immortality. The ice layer is like a giant genetic refrigerator, helping them preserve their genetic blueprints, allowing them to see the light of day again when conditions permit."

Tang Que stood aside, his eyes gleaming, and he talked endlessly: "We have tested all the collected ancient bacteria and rare bacteria, and there are more than a thousand kinds. You must know that there are more than 3 million bacteria in the world. species, and there are only more than 8,000 species that we humans can distinguish."

"After hard work, a brand-new gene-editing protease was finally found in an ancient bacterium. Since this bacterium existed hundreds of thousands of years ago and is shaped like a long bamboo pole, we call it Protobacterium."

"There is also a similar CRISPR system in this bacterium, but it is more simplified, more primitive, and not so complicated."

"Find a single effector protein cutting enzyme in it, which has a small molecular weight but powerful functions, and has strong tolerance to the external environment and wide adaptability."

"This allows it to be flexibly delivered into the cell and reach the edited target without making an overly complicated plasmid."

"It has both DNA and RNA endonuclease activities, and it can complete the processing process by itself without a long string of tracrRNA, so as to achieve a clean gene cutting function."

"It has a simple structure but powerful functions. Compared with Cas9, the difficulty of delivery is greatly reduced, and the target site of genome editing is also greatly expanded. It not only improves the efficiency of gene editing, but also can perform multiple rounds of gene editing on the same site. .”

"It is not as easy to off-target as Cas9, and its positioning and insertion are more precise, and it is easier to operate. It is a more powerful tool for editing multiple gene sites."

"This new gene editing tool is literally made for thalassemia, and we can also genetically modify it to make it more suitable for other different diseases."

"With it, we don't need to painstakingly analyze the genetic makeup of different patients, we just need to locate the mutant genome, and then attach the correct gene fragment to the original cutting protease, put it into a simple plasmid, and it can enter Cells can accurately locate the mutated genome, complete the cutting automatically, and then complete the insertion of normal gene fragments through homologous recombination."

The more Tang Que said, the more excited he became, and his voice became louder: "It is the most powerful gene editing tool that we humans can master at this stage. With it, we will become the greatest biologists in the world, and we will have nothing to lose. cannot."

Wei Kang nodded slightly, his expression excited, and he couldn't help but be infected by Tang Que's passion, and almost lost his composure.

However, as the boss, he still maintained the necessary calm.

"How is the follow-up clinical trial going?"

"Great, we have created a new thalassemia gene drug based on this, and cell experiments show that it is no different from the previous drug effect."

"Because this drug also has a powerful editing function on RNA, unlike CAS9, which can only edit DNA, the new drug can achieve the function of gene editing in vivo, so that patients can be directly administered intrathecally and inject the drug into the bone marrow That is, the process of autologous bone marrow transplantation is eliminated, and the transplantation process and subsequent complications are greatly reduced."

"This is the real gene-editing drug. What is Cas9 that can't be edited in the body? Ours is the most powerful on the surface, and we can just inject the drug directly into the body. Hahaha~"

Tang Que couldn't help laughing out loud while talking.

As soon as he mentioned his new discovery, he immediately became energetic and joyful, and his whole body seemed to be glowing from the inside out.

Wei Kang's hanging heart was completely relieved, and he also laughed.

"Great. Recently, the Broad Institute has been dancing happily. I am worried that I can't deal with them. Now that you have discovered this, I can rest assured."

The corner of Tang Que's mouth twitched, and he said with disdain: "I don't know what's the point of arguing. I just do these fancy things all day long. Is this thing so difficult? Can it work? It still depends on the curative effect. They take With a broken patent, I can’t make anything myself, so what’s the point?”

"Breakthroughs in basic science are good things, but this is something that benefits all mankind. I can't make clinical drugs by myself, but someone else does. Isn't it a win-win cooperation? Why are you still doing three things and four things, and you still have to pinch them in the end? It is a shame for scientists to take patents out of other people's hands."

After he finished the call cursing, he suddenly looked at Wei Kang nervously.

"Mr. Wei, we hold the patent of this original gene-cutting enzyme, won't we mess around like the Broad Institute?"

"We're not going to charge a high gene tax too?"

Wei Kang laughed and said, "Who do you think I am? Sanqing's corporate philosophy absolutely does not allow narrow patents like the Broad Institute to be self-respecting, let alone use such a powerful patent as a weapon to attack advanced technologies. A breakthrough, a company that benefits people."

"Don't worry about this, you have confidence in Sanqing and Huaxia."

Only then did Tang Que heave a sigh of relief and nodded.

Wei Kang pondered and said: "Actually, this matter is very complicated. It is not only related to the thalassemia gene drug, but also related to the food issue and other national disputes. But as a technician, you can just focus on research. Let me deal with these ghosts and monsters."

Then he showed a confident smile: "I was a little worried that I might be forced to give up overseas patients, but now that there is a new big killer, it is obvious that no matter how much they jump around, it is also autumn. The last grasshopper has a few days to live."

Wei Kang left the genetic laboratory and came to his office, looking at the mountains of documents on the desk, his expression turned cold.

On top is a freshly baked court summons.

Since the University of California team tore up the patent license, their domestic branch immediately filed a patent infringement lawsuit to the Kunming Court, demanding that Sanqing Group stop selling thalassemia gene drugs in China.

What the other party did was obviously expressing an attitude and sending out a signal.

Whether they can win or not is secondary, mainly to serve as a deterrent to distract Sanqing's attention, and at the same time try to delay the launch of Sanqing's genetic medicine.

They also knew in their hearts that the possibility of achieving this request was very small, after all, Huaxia was Sanqing's home court.

Sanqing can file a lawsuit slowly, and the two sides are likely to fall into a wrangling battle, and it will take several years to tear up a result.

Even if there is a lawsuit, it will not delay Sanqing's continued sales of the thalassemia gene medicine.

With the backing of the Food and Drug Administration, the possibility of importing Pfizer's thalassemia gene medicine is infinitely close to zero.

Wei Kang picked up the summons, and Zheng Feng's familiar round smiling face appeared in front of his eyes.

He smiled lightly, put it aside casually, and whispered to himself.

"If you want to fight, then fight."