Chapter 53 Zhou Su and Liu Yiyi turned their heads mechanically and looked at Shen Zhe with unbelievable eyes.

“Why do you know the medicine for coronary heart disease so well?” Liu Yiyi asked in shock.

“I said I know how to make medicine. Of course, I know a little bit about all kinds of medicine.” Shen Zhe said lightly.

Understand a little bit?

The girl with short hair who had been standing at the door smiled.

She asked, “What’s your name?”

Shen Zhe smiled, “My name is Shen Zhe.”

The girl took a breath.

It turns out that he is Shen Zhe, a hot topic on the Internet these days!

It turned out to be “I’m not the God of Medicine” that he filmed!

He actually came to their research institute!

Is it to collect materials?

Girls are getting more and more interested.

“Hello, my name is Zhong Ning.”

Shen Zhe nodded very politely, “Hello.”

“Then Mr. Shen, can I ask you one more question?”

“go ahead.”

“Since you know the medications for coronary heart disease, do you know the main categories of medications for coronary heart disease?”

“The first category is antiplatelet drugs, such as aspirin, ticagrelor, etc.; the second category is plaque elimination and hypolipidemic drugs, such as statins, etc.; the third category is drugs that reduce the burden on the heart, such as : Β-receptor blockers, etc. The fourth category is angiotensin-converting enzyme inhibitors or angiotensin II receptor antagonists, such as captopril, cilazapril, etc. There are also some that can improve symptoms Drugs, such as nitrates.”

Hearing Shen Zhe’s words, Zhong Ning’s eyes lit up.

What Shen Zhe said is not bad at all!

Even the drugs have been cited for example!

The dean also suddenly became interested.

“Oh?” The dean raised his eyebrows and asked, “Then do you know which chemical component is missing in the angiotensin-converting enzyme inhibitor or angiotensin II receptor antagonist developed by Zhong Ning?”

“It’s sulfhydryl.” Shen Zhe said without hesitation.

Hear this.

All the people present took a deep breath.



Zhong Ning was stunned.

She has studied for so long.

It turned out to be a sulfhydryl group!

but……

Is Shen Zhe right?

Zhong Ning looked at the dean.

The dean looked at Shen Zhe gently.

This is a little different from the usual dean.

The usual dean is quite serious.

When she first entered the door, the dean still looked impatient.

It seemed that he wanted to drive away a few people in front of him.

Suddenly changed now?

Could it be that Shen Zhe was right? !

At this time, both Liu Yiyi and Zhou Su were dumbfounded.

Those who study medicine must be proficient in chemistry.

Of course they know sulfhydryl groups.

Not only does it know, but it can be said to be very understanding.

Sulfhydryl group, also known as hydrogen sulfide group, has a foul smell, is weakly acidic, and is easily oxidized. It is a monovalent atomic group composed of a sulfur atom and a hydrogen atom. The structural formula is -SH.

However, understanding is understanding.

Why is this chemical ingredient used in the treatment of coronary heart disease?

“Why not hydroxyl?” Zhou Su asked.

Shen Zhe explained, “Of course not. The introduction of hydroxyl groups can enhance the binding force to receptors, increase water solubility, and change biological activity. Substitution of hydroxyl groups on aliphatic chains often reduces activity and toxicity. When hydroxyl groups are substituted on aromatic rings, It is beneficial to bind with the basic groups of the receptor, and enhance the activity and toxicity. When the hydroxyl group is acylated into an ester or alkylated into an ether, its activity is mostly reduced.”

Hear this.

Zhou Su suddenly realized.

Liu Yiyi nodded in agreement.

Shen Zhe went on to say, “The ability of sulfhydryl groups to form hydrogen bonds is lower than that of hydroxyl groups. When sulfhydryl groups are introduced, they are more fat-soluble than the corresponding alcohols and are easier to absorb. Sulfhydryl groups have stronger reducing power and are converted into disulfides; sulfhydryl groups have stronger The nucleophilicity can react with α and β-unsaturated ketones, and can also react with heavy metals to form insoluble thiolates, so it can be used as an antidote, such as dimercaptopropanol. Sulfhydryl can also interact with some enzymes. The pyridine ring forms a complex, which can significantly affect metabolism.”

Everyone in the room was dumbfounded.

How can this be an understanding of medicine!

This is quite thorough!

Some professional terms may not be spoken by these masters of medicine.

It is estimated that only a doctor of medicine can come to discuss with Shen Zhe!

Shen Zhe’s voice fell.

The room fell into silence.

Everyone looked at Shen Zhe dumbfounded.

“Cough cough.” Shen Zhe gave a light cough.

Bring everyone back to reality.

“Dean…” Before Shen Zhe could finish speaking.

The dean stood up with a “teng” sound.

He walked around the table and walked quickly in front of Shen Zhe.

He stretched out a hand and patted Shen Zhe on the shoulder.

Look at Shen Zhe seriously.

The eyes are shining brightly.

“Mr. Shen, the laboratory can lend it to you, but you have to know that anti-cancer drugs are different from those used to treat coronary heart disease. There are many types of cancer. It is impossible to recover from the disease. It can only inhibit the spread of cancer cells. At present, the best anti-cancer drug in the world is Sophie, but we have never worked out the ingredients.”

Shen Zhe nodded.

Before coming, he had also learned about this.

In China, there is no drug that can replace Sophie.

“But I have a request.” The dean continued. .

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