Xueba’s medical black technology system

Chapter 4 Isn’t this too detailed?
Ji Hong's office was open at the moment. Lu Liang stood in the corridor and looked into the office and found that Ji Hong was sitting in front of the computer.

Lu Liang knocked on the door of the room: "Teacher."

Ji Hong looked up and saw that it was Lu Liang, so he smiled and asked, "What, Xiao Lu, what's the matter?"

Lu Liang said: "I drew a synthesis route for the drug, and I would like to ask Teacher to help me take a look."

Ji Hong smiled: "It's the homework from last time, Xiao Lu. What kind of drug synthesis route are you drawing?"

Lu Liang had nothing to hide: "A second-generation drug for the treatment of chronic myelogenous leukemia."

Ji Hong nodded: "It turned out to be the second generation of chronic myeloid leukemia..."

However, Ji Hong's words stopped abruptly just in the middle of his words, and an idea emerged in his mind.

Isn’t there always only one drug for treating chronic myelogenous leukemia, Gleevec? When did second-generation drugs appear?

Is it a recent research discovery?
However, logically speaking, this kind of thing should be breaking news in the field of pharmacy. How come he has never heard of such an important thing, and has never seen relevant research.

Could it be that I am already behind the times and cannot keep up with the current scientific research circle?
An absurd idea emerged in Ji Hong's mind.

After coming back to his senses, Ji Hong quickly opened the computer on the table and asked hastily: "Xiao Lu, where did you see the research? Send me the doi."

Lu Liang quickly explained: "No, Teacher Ji, the research has not reached this stage yet. This is a synthetic route selected by my own research."

After Ji Hong listened, he once again showed a surprised look. It turned out that he had selected them by himself. No wonder he hadn't heard about it. He thought
Just when Ji Hong was about to breathe a sigh of relief, he was suddenly stunned. He twisted his stiff neck and couldn't believe his ears: "Xiao Lu... what did you just say?"

Ji Hong knows very well about innovative drugs.

In the field of innovative drugs, there are so many scientific researchers in China, many of whom have been researching for a lifetime, but they cannot guarantee that they will be able to develop an innovative drug.

But now Lu Liang told him that he had screened and developed a new drug, and it was a second-generation drug for the treatment of chronic myelogenous leukemia. How could Ji Hong believe this?

After coming back to his senses, Ji Hong seemed to realize something. He coughed dryly and said, "Xiao Lu, I know that your monitor's incident has a great impact on your class, but this is not how innovative drugs are developed."

"When we do drug research, we first need to understand the pathogenesis, and then find ways to target the pathogenesis, such as drugs to treat chronic myeloid leukemia. Do you know about chronic myelogenous leukemia?"

"Understood, the ABL gene on chromosome 9 and the BCR gene on chromosome 22 translocated, forming the BCR-ABL fusion gene.

The p210 protein encoded by the BCR-ABL fusion gene has extremely strong tyrosine kinase activity, which significantly increases the phosphorylation of substrate proteins in downstream signaling pathways.

Then it once again activates a large number of downstream signaling pathways such as MAPK and JAK, prompting a large number of undifferentiated mature granulocytes to enter the blood and interfere with the physiological functions of normal platelets and red blood cells? "

Lu Liang quickly replied that although this description is a bit incomplete, the pathogenesis of chronic myelogenous leukemia is exactly like this.

To describe it in a layman's terms, it's like your friend Zhang San and Li Si suddenly went crazy, came to your house, and held a party at your house.

Opening for one day was not enough, they opened for ten days and ten nights.

During this period, I will steal your food, your drink, your bed, and even your wife's bed!
You can endure this, who can endure this!

The key is, you still can’t drive them out!
Although this metaphor may be a little inappropriate, it is almost the same meaning.

Ji Hong was stunned.

He originally thought that he could stump Lu Liang just by asking a few professional questions.

Afterwards, I gave a serious warning, and the matter ended just like that.

Unexpectedly, Lu Liang actually answered.

That's not right...that's not how my script was written.Ji Hong was puzzled.

The reason why Lu Liang is so familiar is entirely due to his research in his previous life.

After coming back to his senses, Ji Hong coughed dryly: "Just understanding the pathogenesis is not enough, but you have to know that what we are doing is small molecule targeted drugs. How can we make the drugs act on the target?"

What is targeting?

If chemotherapy is carpet bombing, no matter how good or bad you are, bombing all the way will kill you and your gang of friends, and there will be no party.

That target is precision guidance.

Kill the Japanese sniper with one shot from eight hundred miles away!

The two are not at the same technical level.

However, Lu Liang nodded and said: "This is simple. Isn't the target the p210 protein? Just prevent the p210 protein and its substrate tyrosine phosphorylation."

If tyrosine is regarded as a switch, phosphorylation is equivalent to a gate valve, and preventing its phosphorylation is equivalent to closing the valve tightly. This is Lu Liang's superficial understanding. Although it is incorrect, it is easy to remember.

If you have to put it in a layman's terms, it would be to lock and weld the door of your house shut so that you can't get in, so they can't hold a party at your house.

At this moment, Ji Hong was a little confused.

That's not right. His academic direction is the research on lung cancer and its targeted drugs. Lu Liang is his student. Even if he knows some academic research, it is related to lung cancer. Why did he suddenly jump to the research on chronic myelogenous leukemia drugs?
But the conversation had reached this point, and Ji Hong could only bite the bullet and say: "Then which compound did you screen?"

Lu Liang took out the blueprint from his pocket that showed the synthesis route for second-generation drugs.

Ji Hong took the drawing and began to think about it. He would pretend to take a look at it later, and then find some mistakes.

Then use this opportunity to guide Lu Liang a little and make Lu Liang realize the rigor of scientific research. After all, being too ambitious is not a good thing for Lu Liang's future development.

Ji Hong looked at the synthesis route while thinking: "Isn't your synthesis route a bit too... too detailed?"

The moment he saw the drug synthesis route on the paper, Ji Hong's eyes suddenly widened and he looked a little surprised.

An outsider might just look at the complexity of the picture, but how could Ji Hong be an outsider?

What he looks at is not the neat chemical structural formulas at all, those things are dispensable in his eyes. What he cares about most is the reaction conditions such as substrate, dosage, and temperature in the synthesis route.

But in the picture drawn by Lu Liang, temperature, time, substrate, dosage...all the reaction conditions were marked on the paper one by one.

All the data is also very accurate, the notes are extremely detailed, and all the equipment that needs to be used is also carefully explained.

The only thing missing is the price of synthetic raw materials.

After coming back to his senses, Ji Hong couldn't help but take a breath and took a closer look.

Judging from the reaction conditions and the structural formula of the intermediate product after the reaction, the synthesis route of this drug turned out to be very reasonable, and even he could not find any faults for a while.

The most important thing is that Ji Hong checked on the Internet and did not find any information about this compound on the Internet.

This means that the structural formula of the second-generation drug Lu Liangkou mentioned is indeed a brand-new compound.

Turtle...could this really be Gleevec's second-generation drug?

An idea emerged uncontrollably in Ji Hong's mind.

(End of this chapter)