Xueba’s medical black technology system

Chapter 243
Lu Liang ignored the speculations and discussions from the outside world.

He is currently busy communicating with people from biological companies about some of the indicators that need to be tested during the experiment, as well as the testing methods.

Because Alzheimer's disease is different from other diseases, drug efficacy cannot be evaluated through simple serological tests in the past.

Instead, it needs to be evaluated through abstract concepts such as cognitive level, memory level, etc.

Therefore, in addition to relying on whole-brain fine imaging technology to systematically detect neuron activation, it is also necessary to conduct some behavioral experiments and observations on mice.

For example, through behavioral observations such as the nesting behavior of mice, the time it takes to identify new objects, and the Morris water maze.

These behavioral tests can determine the animal's cognitive, memory and other neurobehavioral functions, so that the protective effect of new drugs on Alzheimer's disease mice can be systematically evaluated.

The most important of these is the observation of Morris water maze behavior.

The so-called Morris water maze is a platform on which mice can stand in a large circular pool.

The platform was covered with water, making it invisible to the mice, whose task was to find this platform to escape from the water.

Although mice are born to swim, they instinctively resent being in water and will instinctively seek out resting places in the water.

The act of finding a resting place involves a complex memory process, including the collection of visual information related to spatial orientation.

The Morris water maze utilizes this principle.

The mouse's spatial memory and learning ability were judged by using a computer to measure the mouse's movement trajectory in the water and the time it took to find the platform.

Software then analyzes the data to evaluate the efficacy of the drug.

The person who contacted Lu Liang was Tan Bin, the manager of the biological company.

Tan Bin sent a message and asked: "Now that the behavioral test is completed, are there any further tests that need to be carried out? We can help with some anatomy and sampling and other things. These are all included and there is no charge."

Yo, it’s free, and such a good thing.

Then Lu Liang is welcome.

Lu Liang quickly thought about some indicators he still needed to measure after completing the behavioral experiments.

First, make a batch of tissue sections so that the pathological level of the organs can be observed through hematoxylin-eosin staining.
Immunohistochemical staining is then used to assess amyloid plaque deposition in the brain.
Finally. Do another label-free quantitative proteomics test.

The main purpose of conducting proteomic testing is to specifically analyze the molecular mechanism by which the drug improves the learning and memory abilities of Alzheimer's mice and clears β-amyloid.

With these indicators, it is almost possible to comprehensively evaluate the therapeutic effect of drugs on Alzheimer's disease.

Lu Liang sent all the test indicators he needed to Tan Bin.

Lu Liang knew very well that these things were very easy for a biological company.

If it can't do these things, then there is no need for this biological company to continue to operate.

Sure enough, Tan Bin quickly replied with an "ok" gesture.

Afterwards, Lu Liang breathed a long sigh of relief, and then he just had to wait for the results of the biological company.

Lu Liang closed the computer, stretched hard, and then lay on the chair and began to think. He always felt that something was missing today.

Lu Liang turned around and looked around the study room. Today's study room seemed a little too quiet.

No, Wang Wentao didn't come to the study room today.

Lu Liang suddenly realized that there was something missing in the study room.If Wang Wentao were in the study room at ordinary times, with Wang Wentao's nagging character, the study room would not be so quiet.

Lu Liang took out his phone and glanced at the date. Today is not a weekend either. It's not holiday time yet?
Could there be something else going on?

Lu Liang opened the lock screen of his mobile phone and prepared to send a message to Wang Wentao to ask about Wang Wentao's situation.

However, as soon as he opened Penguin, Lu Liang suddenly discovered that there was an unread message. It was a message from Wang Wentao, but Lu Liang's phone was muted at the time and he didn't notice it.

"Brother, I took a few days off from my teacher to go home. Something happened to my grandma."

When Lu Liang saw the content of the message, he couldn't help but frown.

After Wang Wentao got off the high-speed train, he hurried towards the hospital.

He received a message from his mother this morning, saying that when his grandmother was going downstairs this morning, she accidentally fell down the stairs.

When he heard the news, Wang Wentao was immediately anxious. He booked a ticket for the nearest high-speed rail and hurried back.

After arriving at the hospital, Wang Wentao hurried towards the inpatient department. According to the ward number his mother sent him, Wang Wentao reached the floor and began to look for the location of the ward.

"Wen Tao, here."

Wang Wentao suddenly heard shouts coming from behind him. Wang Wentao looked back and saw a woman standing at the door of a certain ward. She was Wang Wentao's mother.

Wang Wentao walked over anxiously, and then asked his mother: "Mom, how is grandma doing?"

After seeing Wang Wentao, Wang Wentao's mother comforted her: "Don't worry, Wentao. The doctor just checked her. Grandma is fine."

After hearing this answer, Wang Wentao breathed a sigh of relief, and the stone hanging in his heart could not help but relax.

Then Wang Wentao asked: "Mom, what happened? Why did grandma fall down the stairs when she was fine?"

Wang Wentao's mother sighed and replied: "You still blame me for this matter. I originally wanted to take your grandma downstairs for a walk today. After I went out, I was going to close the door. But when I turned around, I found that your grandma had fallen down the stairs. ”

"But the doctor checked it out. Fortunately, it was just a little bit of skin damage. Fortunately, I didn't fall anywhere."

After listening to his mother's words, Wang Wentao couldn't help but frown.

After speaking, Wang Wentao's mother said: "Don't worry, go see your grandma."

Wang Wentao nodded. He walked into the ward and saw an old woman with gray hair sitting on the bed.

After seeing Wang Wentao, the old woman was stunned for a moment, then came to her senses, with a kind smile on her face: "Grandson, why are you back? Didn't you go to school?"

Wang Wentao replied: "My mother told me that you fell down the stairs, so I came back to see you, grandma, are you okay?"

The old woman shook her head: "It's really okay. I told your mother and asked her not to tell you, so that you don't have to worry."

Wang Wentao smiled: "Why don't we talk about such an important thing? Grandma, be careful next time and don't fall again."

The old woman also smiled helplessly: "As people get older, they are no longer useful. Originally, the front looked flat, but as I walked, it rolled down inexplicably."

However, when he heard this, Wang Wentao suddenly stopped laughing.

He knew that his grandma's condition might have worsened again.

(End of this chapter)