Xueba’s medical black technology system

Chapter 212 This result is so exciting!
When he woke up the next day, Lu Liang felt a stabbing pain in his head.

Lu Liang hurriedly rummaged through the box and took out the always-prepared ibuprofen from his medicine box. After taking a pill of ibuprofen, the pain symptoms were relieved a lot.

Lu Liang simply cleaned himself up, and then hurried towards the study room.

Yesterday, I handed over the improved drug synthesis route of Clobazam to Wang Wentao and asked Wang Wentao to try to synthesize it.

Lu Liang himself rushed back to the dormitory to sleep.

After all, the efficacy of the Overclocking Capsule is about to expire at that time. Once the efficacy is over, the remaining time is the side effects.

Lu Liang could only get through the side effects of headache by sleeping.

I don’t know what the final synthesis result will be?

If you fail, you have to start all over again.

Thinking of this, Lu Liang couldn't help but speed up his pace.

Soon, Lu Liang came to the door of the study room. He pushed open the door of the study room and found that Wang Wentao was lowering his head and calculating something.

Realizing that the door of the study room was pushed open, Wang Wentao subconsciously raised his head. When he saw Lu Liang pushing the door and walking in, Wang Wentao stood up almost with joy, with excitement on his face.

"Senior brother, you are finally here. I have been waiting for you for a long time." Wang Wentao couldn't wait to come over and said, the smile on his lips couldn't help but rise.

"How's it going? Has it been synthesized?"

Although Lu Liang almost knew the final result when he saw Wang Wentao's expression, he still asked casually.

"It's combined, of course it's combined!"

Wang Wentao said with excitement: "Brother, guess what our total output rate is?"

Hearing Wang Wentao's question, Lu Liang fell into deep thought for a while. After hesitating for a while, Lu Liang asked tentatively: "40%?"

This is not because Lu Liang does not believe in his improved drug synthesis route.

You know, among all current studies, the best drug synthesis route can only achieve a total yield of 30%.

Unless expensive metals are used as catalysts and then equipped with advanced equipment, the total yield may be more than 60%.

But the problem is that this method is only suitable for laboratories and is not suitable for production at all.

Therefore, Lu Liang said that the total yield of his synthesis route is 40%, which is considered very bold.

However, Wang Wentao shook his head: "Be bold, senior brother, be bold!"

"45%?"

Lu Liang frowned and asked in confusion.

Wang Wentao couldn't stand it anymore, so he said: "60%, the final total yield is 60%!"

When he heard the result, Lu Liang looked a little stunned.

He originally thought 40% was high enough.

But the final result still exceeded his expectations. Even Lu Liang himself couldn't help but be confused: "Why is it so high?"

"Isn't this your improved synthesis route? I just followed the method you gave me. You ask me, how do I know?" Wang Wentao shrugged.

Lu Liang hesitated and continued to ask: "What about purity?"

"After the final purification, the purity can reach 99.8%, with known impurities <0.10% and other single impurities <0.05%, which has reached the standard." Wang Wentao said excitedly.

You should know that most national pharmacopoeia standards are purity >99.0% and known impurities.

At present, the purity they can achieve already meets the standards of the Pharmacopoeia.

Lu Liang thought for a moment and then made a decision: "Then the only thing left is the consistency evaluation."

Consistency evaluation, a word specially created for generic drugs.

The so-called consistency evaluation is to see whether the efficacy of your generic drug is the same as that of the original drug.

Although the technical threshold for generic drugs is far lower than that of original drugs, it is never as easy as imagined.

This is like an open-book exam. As long as you can reach 80 points, you will pass.

But if the question allows you to look through the book to find the answer, you may not be able to achieve a score of 80!
The same is true for generic drugs. They need to achieve 80% of the efficacy of the original drug before they can be called generic drugs.

But the problem is, if others put their technology in place, you may not be able to do 80% of what others do.

Therefore, in addition to the fact that the molecular structure of generic drugs must be consistent with the original drug, the purity, crystal form, and absorption and metabolism of the drug in the body cannot be much worse than the original drug.

Otherwise, if the efficacy cannot keep up, it still cannot be called a generic drug.

Among them, the crystal form of the drug is particularly important.

The crystal form of a drug is an important factor affecting the efficacy of the drug. The stability and bioavailability of the drug are directly linked to the crystal form.

To take the simplest example, Plavix, a drug used to prevent atherosclerosis, has a shelf life of three years.

The shelf life of Plavix's generic version is only two years.

This is related to the crystal form of the drug.

Another example is carbon. Due to different crystal forms, some are black graphite and some are sparkling diamonds. The same principle applies.

The consistency evaluation cannot be done by school laboratories and can only be left to relevant professional departments, such as the Institute of Drug Research.Lu Liang summarized the data results and then sent a message to Chen Shen.

At the same time, the Drug Research Institute was in the conference room.

Chen Shen couldn't help but frowned after looking at the results submitted by the researcher in charge of the Luclobazan imitation project.

Then Chen Shen put down the report, sighed and said: "19%, why is the total productivity only 19%? Can it be improved a little? This total productivity is too low!"

This means that from 100g of raw materials, only 19g of clobazone can be made, and the remaining 81% of the raw materials become waste liquid.

The cost of clobazam produced in this way is undoubtedly very high, which will lead to high drug prices.

"My current requirements are not high, 25%. We will achieve a total production rate of 25%. As long as we can achieve 25%, this generic drug technology can be put into production immediately!"

Chen Shen looked at the researchers sitting opposite and said.

After listening to Chen Shen's request, these researchers looked at each other for a while, and they couldn't help but show embarrassment on their faces. They all hesitated, as if they had something to hide.

Finally, the associate researcher in charge of the clobazam generic drug project spoke.

The associate researcher said: "Let's put it this way, Professor Chen, we can achieve a total yield of drug synthesis of 25%."

"But the problem is." The associate researcher changed the topic, "You have to give me time, give me enough time to improve the synthesis route!"

"With such a small amount of time, everyone has been working day and night. Being able to achieve 19% is already our limit."

After hearing the researcher's words, Chen Shen also showed a tired look on his face.

He knew very well that what the associate researcher said was the truth.

Since the clobazam incident came to light, they have been working day and night to develop generic drugs.

If it were in the past, Chen Shen would have given the researcher enough time with a wave of his hand.

But the problem is, what they lack most now is time.

After a short silence, Chen Shen sighed and said, "Okay, just 19%, it's better than nothing."

Hearing Chen Shen's words, several researchers present also breathed a sigh of relief, which meant that their tense nerves could relax at this moment.

Then, the associate researcher seemed to remember something, and he asked: "Suo Chen, didn't you say that besides us, Researcher Lu is also developing generic drugs? How is the situation there?"

Chen Shen said: "The results on his side haven't come out yet."

Chen Shen paused and then explained: "He only has two people on his side, and you have four or five people here. His progress is definitely not as fast as yours."

After listening to Chen Shen's words, the associate researcher sighed and said with a regretful expression: "Professor Chen, then you should send a few more people to Researcher Lu.

If there are results from his side, maybe the overall productivity will be better than what we have done here. "

Chen Shen waved his hand: "Okay, let's leave this matter as it is for the time being. We'll quickly complete the consistency evaluation so that we can give an explanation to those families."

After finishing speaking, Chen Shen was about to end the meeting and get up to leave, but his cell phone rang at this time.

Ok?
After glancing at the messages received on his phone, Chen Shen couldn't help but frown and let out a sound of surprise.

The associate researcher asked curiously: "What's wrong, Suo Chen?"

Chen Shen said, "Lu Liang sent a message. It seems that the results are out."

Chen Shen's words immediately attracted the attention of several researchers present, and the associate researcher also showed surprise on his face: "So quickly, aren't there only two of him?"

Another assistant researcher also urged: "Suo Chen, hurry up, let's take a look at the results from Researcher Lu?"

Chen Shen smiled and said: "How about it, it will definitely be better than your results."

The associate researcher smiled and said: "Not necessarily, Suo Chen, you have to think about it, there are only two of them, and the time is so short, the workload can be described as explosive."

"So, maybe our results will be better."

Looking at the several researchers joking around, Chen Shen smiled and shook his head. Then he clicked on the report Lu Liang sent him with great anticipation and glanced at the final results on the report.

Overall yield: 60%.

When seeing this result, Chen Shen was stunned for two seconds.

After coming to his senses, Chen Shen quickly took out his glasses from his pocket, put them on, and then took a closer look.

60%!

Chen Shen's brain went blank with a bang at this moment, and even his breathing stagnated.

Immediately afterwards, his breathing became rapid, and his old cheeks turned red.

Shocked!

No, this result cannot be said to be shocking, it can only be said to be exciting!

He only felt that his heart was a little unbearable now, because his heart rate was rising uncontrollably at this moment.

You know, Chen Shen's original expectation was to achieve a total output rate of 25%. In Chen Shen's view, if this result can be achieved, it can be regarded as a perfect end to the work.

But he never expected that Lu Liang would give him such a terrifying result.

(End of this chapter)