Xueba’s medical black technology system

Chapter 210 Temporary mission, imitation clobazam
Disease is not uncommon in this world.

But some of these diseases have strange symptoms, are rare in number, and difficult to treat.

Because this disease is so rare, it is also called a "rare disease" or an orphan disease.

According to the domestic "Rare Disease Definition Report", diseases with an incidence rate of less than 14 in [-] newborns, a prevalence rate of less than [-] in [-] people, and less than [-] affected people are considered rare diseases.

According to incomplete statistics, there are more than 7000 known rare diseases.

And the drugs used to treat these rare diseases.

It is vividly called-orphan drug!

As early as 2008, clobazam had been included in the ranks of orphan drugs.

Common epilepsy diseases are not rare, and there are many drugs used to treat epilepsy, such as carbamazepine, phenytoin and the like.

But some of the epilepsy patients have refractory epilepsy, such as severe myoclonic epilepsy in infants.

Ordinary anti-epileptic drugs have no effect on them.

At this time, only clobazam can be used.

These refractory epilepsy are also rare diseases.

Lu Liang still has some knowledge about orphan drugs. In fact, he has developed an orphan drug before.

That is emicizumab, a drug used to treat hemophilia.

Wang Wentao asked with some confusion: "What does making a generic drug of clobazam have to do with whether it is an orphan drug?"

Lu Liang glanced at Wang Wentao and then said: "Let me ask you, suppose you are the owner of a pharmaceutical factory. A box of medicine costs you 100 yuan and you sell it for 150 yuan a box. Can you make this kind of medicine?"

"Of course I will." Wang Wentao replied matter-of-factly.

The net profit has reached more than 30%, why not do it?
Lu Liang continued: "But nationwide, you can only sell a maximum of 2000 boxes a month. Are you still going to do it?"

Wang Wentao was stunned.

Because this means that this drug can only bring in profits of up to 10 yuan a month.

This may not be worth the daily profits of some pharmaceutical companies.

Even for a small pharmaceutical company, these profits may not be enough to cover labor costs.

How is it possible to do this!
Lu Liang shrugged: "That's the problem!"

It's not a patent restriction or a technical issue, it's purely because of one thing.

He can't make any money producing a drug like clobazam!
This is a rare disease, and there may be only hundreds or thousands of people suffering from this disease.

This means that there are only so many people who will come to buy this medicine.

In the eyes of those pharmaceutical companies, with such a small profit, it is better not to do it and save trouble.

If you have that spare time, you might as well make money by producing a few more boxes of cold medicine.

Without the motivation of profit, pharmaceutical companies will lose interest in the development of drugs to treat these rare diseases, and patients with rare diseases will be abandoned like orphans.

However, in recent years, orphan drugs for the treatment of rare diseases have been continuously developed.

Because those pharmaceutical giants thought of another way to make money.

In order to obtain enough benefits from rare disease patients, they raise the price of drugs to sky-high prices!

Novartis has developed a one-time AAV9-based gene therapy Zolgensma to treat spinal muscular atrophy, priced at $225 million per dose

Bluebird Biotech in New York has developed Skysona, a gene therapy that slows down the progression of early-stage active adrenoleukodystrophy and neurological dysfunction in boys aged 4-17 years old. One injection costs US$300 million!
In addition, Bluebird Bio has also developed Zynteglo, a gene therapy for the treatment of patients with beta-thalassemia, priced at US$280 million!
In front of these drugs, CAR-T cell therapy worth 120 million per injection and Gleevec worth 4 bottles can only be regarded as younger brothers.

As for why clobazam has not been raised to sky-high prices, it is because it is a generic drug.

Not Zolgensma, not Zynteglo, not the original drug!

If a generic drug is raised to a sky-high price without much investment in R&D, public opinion will be enough to crush the company.

Of course, besides not making money, there is another reason that is also important.

That is the nature of clobazam itself.

Clobazam is a controlled Class II psychotropic drug and is a drug that can be linked to drugs.

This means that if you want to imitate clobazam, you must go through strict applications and pass layers of approvals before you can produce clobazam.

Moreover, even with approval, the production and sales of clobazam are still subject to severe controls.

After all, this is no ordinary drug.

Similarly, it is precisely because of these conditions that some small pharmaceutical companies that intend to produce generic clobazam do not have those conditions and cannot obtain approval.

Big pharmaceutical companies that have enough conditions to pass the approval are too lazy to make such low-profit drugs.

Therefore, this has resulted in no clobazam drug being marketed in China so far.

Wang Wentao was silent for a moment. He scratched his head, his expression a little solemn, as if he was hesitating for something.

Lu Liang glanced at him. Many times, Wang Wentao would express his thoughts directly on his face. Lu Liang asked, "What are you thinking about?"

Wang Wentao murmured: "I don't think we should stop producing a drug just because it is not profitable enough and the number of patients it can treat is not large."

"So?" Lu Liang asked, placing the cup in his hand.Wang Wentao's expression suddenly became hesitant, but after hesitating for a while, he gritted his teeth and said, "I want to try to imitate clobazam in the laboratory."

These words seemed to have inspired Wang Wentao to have great courage. After finishing speaking, Wang Wentao glanced at Lu Liang secretly.

After all, to be honest, the Clobazam incident had almost nothing to do with him.

Moreover, even if he imitates clobazam, it still cannot be put into production without approval and permission.

What's more, he has a lot of things to do now, and there are still two batches of experiments waiting to be done. It can be said that he has no time to do such things.

Therefore, his proposal is not only a waste of time, but also meaningless.

Although Wang Wentao felt that his proposal would most likely be rejected by Lu Liang, he still wanted to try it.

"If you want to try it, then go ahead and try it." Lu Liang smiled and then said.

This answer was somewhat beyond Wang Wentao's expectations.

Wang Wentao asked tentatively: "Brother, do you agree?"

Lu Liang replied calmly: "Yes."

This caught Wang Wentao off guard for a moment, and he continued: "Then I still have two batches of experiments to do here. Aren't you afraid that I will waste my time?"

Lu Liang smiled: "Then you should hurry up."

After confirming that Lu Liang really agreed, Wang Wentao immediately cheered up. He took a deep breath and said, "That's okay, I'll do it as soon as possible."

After watching Wang Wentao energetically search for research on Clobazam, Lu Liang once again withdrew his gaze.

At this moment, in front of Lu Liang, the system panel had popped up.

[Temporary task: clobazam imitation]

[The value of a drug cannot be measured by the profits it brings. 】

[Time countdown: 15 days. 】

[Task Reward: Rewards will be given based on the score. 】

Do you make generic drugs?
Looking at the temporary tasks that suddenly popped up in the system panel, Lu Liang was thoughtful.

"Songsong's dad, is it really okay for us to do this?"

In the group, a mother asked worriedly.

Songsong's father is now exhausted: "We have no other options. We can't just sit back and wait for death, just watching the child take no medicine!"

They used to rely on clobazam purchased from Iron Horse to control their children's condition.

But after Tiema was arrested, they were completely unable to buy medicine.

Therefore, after some discussion, everyone in the group finally unanimously decided to jointly post this matter and seek help from the society.

If it can arouse repercussions in society, it will not only help themselves, but also help the arrested iron horses.

It's one of the few things they can do now.

"But, if we do this, won't we cause trouble?" A mother in the group suddenly asked worriedly.

You must know that when Tiema was arrested, he was guilty of drug trafficking. She did not want to get into trouble because of this matter.

"Yeah, we just want to buy some medicine!"

"Is there no other way? Isn't this a bit too extreme?"

Following the mother's speech, several people in the group began to agree, and they were reluctant to get involved with this matter.

It is human nature to seek advantages and avoid disadvantages.

Seeing this scene, Songsong's father immediately sent a message: "Don't forget, Tiema has helped us purchase medicines so many times before. Apart from postage, she has never received any other money from us. She has every reason." She only buys medicine for her own son."

"It can even be said that if she hadn't helped us, she wouldn't have been arrested."

"And now that something happened to her, are we going to ignore it?"

Many other people in the group also echoed: "Yes, if we really ignore the iron horse, we would be a bit ungrateful."

"And now that she has been arrested, if we ignore her and do something, who else will be willing to help us purchase drugs in the future!"

Looking at the speeches in the group one after another, those few who objected fell silent at this moment.

They also knew in their hearts that these words were correct. If they really ignored Tie Ma, even if someone could buy medicines for them like Tie Ma in the future, they might not be willing to help them.

After seeing that no one in the group objected, Songsong's father said, "Since everyone has no questions, please sign and take photos and send them to me."

Soon, photos of signatures were posted one after another in the group. They not only contained signatures, but also had bright red handprints on them.

Every signature, every handprint represents a family and a child waiting for clobazam.

There are more than 1000 such photos, representing more than 1000 families seeking help.

Looking at these handprints, Songsong's father took a deep breath. He quickly put the handprints together, and then wrote a letter asking for help - "How to keep our children alive!" 》

After finishing writing the letter for help, Songsong’s father hit Enter hard, and the letter and the photos were uploaded to the Internet.

(End of this chapter)