Xueba’s medical black technology system

Chapter 204 Kidney and brain cancer, the possibility of multikinase inhibitors

Wang Wentao cried to Lu Liang with a look of despair.

"Originally, you only needed to publish two articles to graduate, but starting from our class, it is required to publish three articles to reach the graduation level!"

"Moreover, all articles are required to be in core journals, and there must be two experimental articles among the three articles."

Wang Wentao looked like he was about to cry: "These teachers are so relaxed and talkative. Do you know how much psychological shadow this paper will have on us people?"

After listening to Wang Wentao's words, Lu Liang nodded suddenly: "That's it?"

Wang Wentao's eyes widened; "Brother, don't speak so lightly, okay?

That is a core journal. When it comes to your mouth, it feels like pancakes on the roadside. It is within your reach. "

After listening to Wang Wentao's words, Lu Liang pondered for a while: "Ah, isn't this just something you can post casually?"

Wang Wentao opened his mouth and was about to refute, but when he thought about it carefully, he suddenly realized.

The journals that Lu Liang chooses are all from Science, Nature, etc., and no matter how bad they are, they are also from top journals such as NEJM, Lancet, and JAMA.

For Lu Liang, a core journal seems to be just a matter of publishing casually.

Wang Wentao's head hung low.

Lu Liang sighed and said, "Calm down, haven't you already published an article?"

Previously, when Lu Liang was writing a study on PD-1/TIGIT inhibitors for the treatment of lung cancer, he still had some remaining data that was useless, so he handed these data over to Wang Wentao.

Wang Wentao also pieced together pieces, and then put together an article and submitted it to a Sci with three areas and three points.

The email has been received so far and can be counted as one article.

"But there are still two more." Wang Wentao said with a frown.

Lu Liang replied: "Then go to the teacher and ask the teacher to point you in two directions, and then do the experiment."

"The teacher went on a business trip. He said he would come back and talk to me in detail, but I don't know when he will come back." Wang Wentao sighed.

This made Lu Liang a little dumbfounded for a while.

When it comes to treating students, Ji Hong has always adopted a free-range policy, and he is also very Buddhist-like, unlike other tutors who follow you every day and push you.

If you don't go to him, he won't come to you.

This has led to Wang Wentao basically following himself now.

Thinking of this, Lu Liang couldn't help but sigh, he had to do it himself.

However, I currently don’t have any good ideas that I can give to Wang Wentao for experimentation.

As Lu Liang thought about it, his eyes couldn't help but move to the paper on his screen.

Suddenly, a flash of inspiration flashed through Lu Liang's mind, and an idea suddenly emerged.

He remembered that kidney cancer and brain cancer are also hypervascular tumors and are the same type of cancer as liver cancer.

Since this multi-kinase inhibitor inhibits the proliferation of liver cancer cells by inhibiting the formation of blood vessels.

Therefore, in theory, multi-kinase inhibitors can be used in the treatment of kidney cancer and brain cancer, and they can work.

It is a very common thing in medicine that one drug is used to treat multiple diseases.

These two batches of experiments can just be handed over to Wang Wentao, and the results can be used by Wang Wentao to publish articles!
And this is just an attempt. Even if Wang Wentao fails, it doesn't matter.

Of course, it would be better if it succeeds.

Lu Liangliang made up his mind.

Thinking of this, Lu Liang said: "Let's see, Wen Tao, you go to a biological company to order two batches of mice, mice for kidney cancer models and brain cancer models, and then you take multikinase inhibitors and make two more batches. test."

"After sorting out the results of these two batches of experiments, it should be enough for you to publish an article."

Although this is a little tricky, it is not a problem to publish two core journals.

After hearing what Lu Liang said, Wang Wentao suddenly looked overjoyed. He pinched his throat and said angrily, "Brother, I know you won't just sit back and watch others."

"vomit!"

Lu Liang rolled his eyes: "If you keep talking like that, you'll just have to fend for yourself."

Wang Wentao shivered and quickly returned to his normal posture. Then he asked: "Brother, can multikinase inhibitors work on kidney cancer and brain cancer?"

Lu Liang replied: "Theoretically, it is possible, but in practice it may not be possible."

The reason is also very simple.

Although kidney cancer, brain cancer and liver cancer are all hypervascular tumors.

However, the locations of the disease are different, the cell tissues are different, and the mechanisms of the disease are also different.

After all, the sophistication and complexity of genes are beyond imagination, and even slight differences may lead to completely different results.

Therefore, kidney cancer and brain cancer may avoid the effects of drug molecules by regulating other signaling pathways.

Therefore, whether multi-kinase inhibitors can be effective in the treatment of kidney cancer and brain cancer requires a trial to know.

Wang Wentao felt a little discouraged all of a sudden: "Brother, tell me, what should I do if I fail? Then I won't be able to publish articles?"

Lu Liang looked at Wang Wentao and said, "Who told you that you can't publish articles if you fail?"

Wang Wentao scratched his head, which touched upon his blind spot of knowledge: "But, the drug has no effect, how can we publish an article?" Lu Liang said: "If it succeeds, you can just publish an article."

“If it fails, you can analyze why the drug inhibits liver cancer cells but has no effect on kidney cancer and brain cancer cells, which are also highly vascular tumors.

What is the reason for this and which part of the cellular mechanism prevents the drug from exerting its effect? ​​This is also a matter of research. "

Science is about constant exploration through failure. As long as the analysis is adequate, the result of failure will still be a rare and valuable achievement.

After listening to Lu Liang's words, Wang Wentao suddenly realized: "So it can still be like this!"

After listening to Lu Liang's analysis, Wang Wentao happily ran to prepare.

Lu Liang couldn't help but shook his head.

After settling Wang Wentao's matter, Lu Liang picked up his phone and was about to ask Ji Hong where to submit his article.

However, just as Lu Liang picked up his phone, he suddenly found that the status bar of his phone showed that he had more than a dozen missed calls.

Since he was in the study room, he muted his cell phone, so he didn't receive these calls.

This made Lu Liang a little confused and didn't quite understand what was happening.

After coming back to his senses, Lu Liang carefully looked through the missed calls.

He found that these phone numbers were all unfamiliar to him, and they were all the same landline numbers.

Isn't this a scam call?

Lu Liang was a little confused. After hesitating for a moment, Lu Liang was wary and casually clicked on a phone number among the unanswered calls to call back.

Soon, the other party answered the phone, and before Lu Liang had time to ask, an enthusiastic voice came from the other end of the phone.

"Is this classmate Lu Liang?"

Lu Liang raised his eyebrows.

Hey, liars are quite polite nowadays.

Lu Liang replied: "Yes, who are you?"

There was joy in the other party's voice: "Hello, classmate Lu Liang, this is the Admissions Office of West China Medical College."

However, before the other party finished speaking, Lu Liang hung up the phone.

Oh, can the current fraud be more professional?

At least get the information before committing fraud. Go to the Admissions Office of West China Medical College, which is one of the three and five hospitals. These scammers really dare to speak out.

Besides, I am a college student, not a high school student.

The admissions office only calls high school students, so why call me a college student?

Not long after hanging up the phone, Lu Liang saw his phone screen light up and the other party called again.

Hey, the liars these days are pretty persistent.

Lu Liang hung up again without thinking.

After doing all this, Lu Liang put the phone call behind him, and then began to think about which journal he should submit his paper to.

Later, Lu Liang sent a message to Ji Hong asking for his opinion on the submission.

After reading Lu Liang's article, Ji Hong gave a simple opinion: "Choose one of the four Lancet series."

The meaning is very simple. Just choose any of the four top medical journals and submit to it.

Lu Liang wanted to do this at first, but there was one thing that made Lu Liang a little worried.

Of course, Lu Liang was not worried that the quality of the article was not good enough and would be rejected.

On the contrary, he is still confident in the quality of the article. After all, it has been systematically graded and has no water content.

What really worries Lu Liang is that if he always submits articles to the four major medical journals, he will be suspected of having any PY transactions with the editors of the journals.

This was the point that kept Lu Liang hesitant.

Therefore, Lu Liang’s idea is to invest in sub-journals such as Science Signaling and Nature Medicine. Although the impact factors of these sub-journals are not as good as those of the four major medical journals, they are also top journals.

After learning about Lu Liang's thoughts, Ji Hong felt dumbfounded for a while.

"There is no need to worry about this. Everyone can see the quality of the article at a glance."

Ji Hong replied: "As long as the quality of the article is high enough, no matter how many articles are published, no one will have any objections."

"Besides, if it can be submitted to The Lancet, there is no need to submit it to other journals."

After seeing Ji Hong's reply, Lu Liangliang's concerns were almost dispelled.

Now that Ji Hongdu has said so, what else does he have to worry about.

After carefully checking the paper, Lu Liang opened his mailbox. After thinking for a while, Lu Liang chose to submit the paper to BMJ, the Medical Journal on which the Sun Never Sets.

After sending the email in his mailbox, Lu Liang received an automatic reply email from the editorial department of The Sun Never Sets Medical Journal, indicating that Lu Liang's submission had been received.

After submitting the article, Lu Liang breathed a sigh of relief. He picked up his phone and looked at the time. It was already getting late and it was time to go back to the dormitory.

Lu Liang shut down his computer, then simply cleared the desktop and left the study room.

(End of this chapter)