Xueba’s medical black technology system

Chapter 2 A brand new synthesis route (modified)

Lu Liang chewed the information in his mind carefully.

Like chewing gum, greedily squeezing out every ounce of sugar.

After thoroughly digesting the drug synthesis route, Lu Liang's eyes suddenly became brighter.

I don’t know if this was the first time he analyzed the reason for his good luck. Lu Liang discovered that the drug synthesis route he had obtained was a synthesis route that had already been optimized.

The quality of a general drug synthesis route mainly depends on three points: complexity of steps, total yield, and cost!
The synthesis steps cannot be too complicated. If it is too complicated, how can we carry out large-scale industrial production? How can we make money without large-scale production?

Just like Buddha jumping over the wall, there is no way to make it into an assembly line.

If it really turns out to be an assembly line, can it still make the Buddha jump over the wall?

What Lu Liang obtained was a synthetic route with simple steps and suitable for large-scale industrial production.

The route uses 4-dichloro-6-methylpyrimidine as the starting material, and only needs two condensations and one purification to obtain the second-generation drug dasatinib.

The only drawback may be that the cost is a little higher.

But it doesn't matter. The most important thing now is to get the drug out. As for the cost, it is not within Lu Liang's consideration at all.

Lu Liang dug out another piece of A4 paper in the drawer, spread it out, and began to record the drug synthesis route for dasatinib on the A4 paper.

Lu Liang drew the chemical structural formula of 4-dichloro-4-methylpyrimidine on A6 paper, and then began to mark the reaction conditions of the first step next to it.

“反应过程需要以四氢呋喃作为溶剂，通过加入4，6-二氯-2-甲基嘧啶、叔丁醇钠、2N盐酸等原料，在10℃~20℃之间搅拌5小时……”

The system provides not only chemical structural formulas, but also detailed reaction conditions in drug synthesis routes.

In the drug synthesis process, the reaction conditions of the compounds are equally important.

Regardless of the reaction temperature, time or the amount of raw material and substrate added, even a small deviation in the index will greatly affect the final result.

Every data in the reaction conditions is the best data that the predecessors have figured out after countless failures.

If Lu Liang was left to explore by himself, this huge workload would require him to spend at least half a year tinkering with it.

The second step is to add raw materials such as N-hydroxyethylpiperazine. The reaction temperature is 85°C. After several steps of cooling, crystallization, and drying, the final product is the second-generation drug dasatinib!

But that doesn't mean it's over.

If the current dasatinib was sold, it would probably kill someone on the spot.

After all, the dasatinib produced now is only a crude product, which is mixed with a large number of impurities. Those impurities are other chemical reagents left over from the synthesis process.

Therefore, if you want to get a drug that can actually be taken, further purification and refinement are needed.

The purification process is relatively simple compared to the previous reaction. Methanol and ethanol ethyl ester are added to the reaction kettle, stirred and mixed, and then the crude dasatinib is added.

Methanol and ethyl acetate are two common refining reagents in the medical field, but they dissolve different impurities.

The combination of the two can dissolve more impurities.

Anyone who understands the purity requirements of drugs can understand it, and even those who don’t understand it can understand it.

Lu Liang continued to draw the synthesis route on the paper.

"Brother Lu, why have you started drawing the drug synthesis route again? Haven't you already finished it?"

Liu Qi, who was standing next to him, noticed Lu Liang's movements and asked with some confusion.

"I thought of a simpler synthesis route, so I drew it again."

Lu Liang said casually, after all, he couldn't say that this was a synthesis route for second-generation drugs. After all, there were no second-generation drugs in the world.

Liu Qi had a look of surprise on his face, but he soon realized something was wrong.

Because he found that the computer on Lu Liang's desk was not turned on, and there were no books on the desk.

This also means that Lu Liang did not consult any reference materials when drawing this drug synthesis route.

How to draw a picture without any reference materials? Liu Qi glanced at it in confusion, wanting to see what Lu Liang was drawing.

However, when he saw the drug synthesis route drawn by Lu Liang, his eyes widened.

I saw that the A4 paper was filled with various chemical structural formulas, and reaction conditions were written next to each chemical structural formula.

At a glance, it seems as complicated as a heavenly book.

You call this thing simple?
Of course, complexity is not the point.

The key point is that although the synthesis route drawn by Lu Liang is complicated, the ideas are clear and the drawings are neat.

Even a half-professional person like him can actually see every step of the synthesis clearly.

This made Liu Qi suddenly feel hit hard.

He was puzzled. Even though everyone was taught by a professional teacher, why was there such a big difference?

After coming back to his senses, Liu Qi subconsciously opened his mouth to ask Lu Liang how he drew such a picture.

However, after seeing Lu Liang's focused look, Liu Qi hesitated for a moment, and finally shut his mouth obediently.

He didn't want to make people uncomfortable.

However, Liu Qi felt that he should not be the only one to be hit, but other students should also feel the feeling of being hit.

Liu Qi stood behind Lu Liang, preparing to take a picture of the drug synthesis route drawn by Lu Liang, and then send it to the class group.

Lu Liang noticed Liu Qi's movements, and he dug out the homework he had completed before from the drawer.Gleevec drug synthesis roadmap.

"Take this picture."

Lu Liang said.

On the one hand, this Gleevec drug synthesis route is more complete and clear; on the other hand, he does not want this matter to be known to others.

After Liu Qi finished filming, Lu Liang once again focused all his attention on the synthesis route of dasatinib. He continued to draw various chemical structural formulas on A4 paper.

Meanwhile, the girls' dormitory.

"Wow, Shishi, your drug synthesis route is too beautifully drawn."

Several girls were talking around the table of a girl with a high ponytail.

"It's okay, it's not as powerful as you said."

Although Ruan Shishi was a little embarrassed when faced with the compliments from her roommates, she couldn't help showing a proud look on her face.

You know, in order to draw the synthesis route of this drug, she has been browsing various documents on CNKI for the past few days, slowly chewing on professional terms that she did not understand word by word.

She still spent a lot of thought on this after-school homework.

This is also the source of her pride.

"There should be no one in our profession who can paint better than Shi Shi."

"Shishi, you can definitely get high marks in this professional course."

"That's not true. In our family, Shishi is a top student. She ranked first in grade last semester."

"Shishi, when you get the scholarship, you will treat us to dinner."

Ruan Shishi also stuck out her tongue cutely: "Definitely."

Just as the girls were chattering around Ruan Shishi, a ding-dong message suddenly sounded in the dormitory, interrupting several people's conversations.

"It's my cell phone." A girl ran quickly to get her cell phone in slippers.

"Who sent you the message?"

"I don't know, it's the news in the class group." The girl replied.

Soon, she opened the class group. After seeing the message in the class group, the girl's eyes widened.

"What's wrong?" Someone noticed something unusual and asked curiously.

Only then did the girl come back to her senses, and she replied: "You guys, please look at the class news."

Ruan Shishi and others also took out their mobile phones one after another and browsed the messages in the class group.

When they saw the news in the group, Ruan Shishi and others were shocked.

I saw an extremely complicated drug synthesis route posted in the class group. It was exactly the synthesis route for second-generation drugs drawn by Lu Liang.

At this moment, the class group was already in an uproar.

"Who drew this?"

"Are there any other academics like this in our class?"

"But I am uneducated and can only hold grass, awesome!"

"I originally thought Lu Bu was already invincible. Whose subordinate is this?"

"This is still unfinished!"

In the pure version of the class group, there are no teachers or counselors, so everyone can speak freely, and the screen is full of exclamations that are about to overflow from the screen.

Reading through the messages in the group, Ruan Shishi slowly recovered from the shock.

Then she looked back at the drug synthesis route she had drawn.

Subconsciously, he compared his drawing with Lu Liang's drawing.

Obviously I thought the painting was neat and beautiful just now, but now when I look back, I feel it is so rough!

There is no harm without comparison.

"Looking at the back of this person in Hua Tu, it looks like he is Lu Liang from our class?"

"Is that the guy who doesn't like to talk much? It turns out he is so powerful."

Someone in the girls' dormitory was talking quietly.

When she heard this sentence, Ruan Shishi couldn't help but frown, and then searched for this person's appearance in her mind.

Soon, the image of a bookish boy appeared in Ruan Shishi's mind.

In Ruan Shishi's impression, the boy named Lu Liang was usually taciturn in the class. He basically immersed himself in doing his own things and rarely talked to other students in the class.

How did he become so powerful all of a sudden?

This made Ruan Shishi, who had always been strong, suddenly feel a sense of crisis that her position as the top student was being challenged.

It's okay, this is just a drawing, you can do better than him next time, Ruan Shishi silently encouraged herself in her heart.

(End of this chapter)