Xueba’s medical black technology system

Chapter 196 A multikinase inhibitor
When he saw this news headline, Zhao Lin suddenly frowned.

Even without reading it, Zhao Lin could already guess what the content of this report was about.

Although he could guess that this report was in the dark, Zhao Lin chose to click in after hesitating for a moment.

Soon, Zhao Lin finished reading this report.

The entire report can be described in two words: mean and sarcastic.

The smell of ridicule overflows from every word, and it feels like I want to stick it on your face and mock you.

The comment area below was already noisy at this moment. Some people seemed to have been patient for a long time. After seeing this report, they couldn't wait to jump out.

"Have you seen it? We must respect the objective laws of science and understand what science is."

"There are so many pharmaceutical giants in this country. Who else is more authoritative than them in this regard? Everyone has said so, is there anything wrong?"

"He really dares to say that he can develop a drug within a month. If he can develop a new drug within a month, my sows can climb trees."

"It's okay to brag, who can't? It's just that when the bullshit is broken, your face may feel a little painful!"

"I really don't understand what those people are so happy about. They fooled you a few times and you still took it seriously."
Looking at the comments below, Zhao Lin suddenly felt angry. He also wanted to post a few comments to retaliate, but as soon as he sent them, he was directly submerged in the vast ocean of the comment area, without even making a ripple. .

This made Zhao Lin angry and anxious, but there was nothing he could do about it.

At this moment, Fan Zeng once again sent a message to the patient group: "Everyone, you should have finished reading the report."

"If you need to buy medicine, remember to come to me/smile!"

The veins on Zhao Lin's forehead jumped at this sight, not just Zhao Lin, there were patients in the group who were even more irritable than Zhao Lin, and they jumped out and scolded Fan Zeng.

Fan Zeng did not argue with the patients in the group. He knew that he alone could not win against so many people.

So after sending the message, Fan Zeng went offline directly and did not reply a word despite being scolded by so many people.

And as many patients in the group calmed down after venting their anger, a depressing atmosphere once again enveloped everyone.

It's not that they don't want to believe Lu Liang, it's just that in a month, this is really unbelievable.

They were unwilling to face this matter before, so they all chose to avoid talking about it.

But now, the BBC's report is like peeling off the scab, exposing the bloody facts to them, forcing them to face it.

"The BBC report cannot be believed. It's not like everyone doesn't know what that company is like."

After a long time, someone posted a message in the group, seemingly wanting to give some psychological comfort to the patients in the group.

"That's right. Those comments in the comment area are from scalpers at first glance. They are worried that the medicine will not be sold, so they say this deliberately."

"Especially at this time, everyone must not be chaotic. If there is chaos, those scalpers will have an opportunity to take advantage of it."

Soon, some patients echoed this.

Although some people want to make the atmosphere in the group as relaxed as possible, there are only three or two people who send messages, and more people are silent at the moment.

Even Zhao Lin couldn't help but purse his lips. Although he had enough medicine in his hand, he didn't have to worry about what to do after finishing the last bit of medicine like the patients in the group.

But seeing these patients in the group, Zhao Lin's heart still trembled, and his expression became worried.

Lu Liang didn't know what was happening online at the moment, and he had no time to care about what was happening online.

Because everything here is already here.

Tian Li's drug samples have been sent over. Just now, the post station sent a message asking him to pick them up. At the same time, people from the biological company here also called. The mice were about to be delivered and asked him to come over.

Lu Liang put away his cell phone and called Wang Wentao: "Wen Tao, go to the laboratory building. People from the biological company will send mice over later."

After Wang Wentao put away his phone, he didn't hesitate too much. He nodded and replied: "Okay, I'll go over now. Then, senior brother, won't you go over?"

"I'm going to get something." Lu Liang said.

Wang Wentao also knew that time was urgent, so he did not dare to neglect and hurriedly closed his computer.

After telling Wang Wentao to remember to ask someone from the company to get the invoice, Lu Liang hurried downstairs.

After he scanned a small electric donkey on the roadside, he rode the small electric donkey towards the express store.

Soon, Lu Liang got the drug sample this time.

However, compared to the large packages of drug samples sent by Tian Li in the past few times, the samples sent this time are very light.

Lu Liangfang weighed it in his hands. The total weight was about one or two kilograms, which was much lighter than the express delivery sent by Tian Li before.

However, this is normal. The drug samples sent before were all monoclonal antibodies.

These antibodies need to be biologically active at low temperatures, so in order to ensure that there will be no problems with the antibodies, Tian Li fills the box with ice packs every time.

It can be said that [-]% of the weight of express delivery comes from ice bags.

The weight of monoclonal antibody samples accounts for less than [-]%.

But this time it was different. The drugs Tian Li sent this time were chemically synthesized drugs that could be stored at room temperature without the need for ice packs to cool down.

Lu Liang opened the express package and revealed the samples inside. It must be said that Tian Li did a good job with the details.There is also a black opaque plastic bag inside the express package. This kind of chemical medicine is basically stored in the dark.

Because some special drugs will undergo oxidation, reduction, decomposition and other reactions after encountering ultraviolet light.

Lu Liang opened the plastic bag and saw some white powdery objects in ziplock bags.

This is the drug that Lu Liang analyzed this time.

A second-generation multikinase inhibitor!

What are multikinase inhibitors?

This means that it can target multiple molecular targets at the same time and play an anti-cancer role by inhibiting these receptors.

Sorafenib developed by Bayer is a multi-kinase inhibitor.

There are two drug targets of sorafenib, namely VEGFR and RAF.

Sorafenib achieves the purpose of treating liver cancer by inhibiting these two signaling pathways.

Lu Liang’s second-generation multi-kinase inhibitor has as many as five targets!
They are VEGFR, FGFR, PDGFR, KIT and RET, these five targets.

These five signaling pathways have different functions.

There is no need to say more about the vascular endothelial growth factor VEGFR.

As a key signaling pathway for angiogenesis, inhibition of VEGFR can inhibit tumor angiogenesis, leading to tumor starvation and hypoxia, leading to severe growth retardation or cell death.

Among them, the effect on the two targets of FGFR and RET is the unique feature of the second-generation multi-kinase inhibitor.

FGFR is also known as fibroblast growth factor. Its main role is to participate in cell development, differentiation, survival, migration, and canceration.

Excessive activation of the FGFR signaling pathway can induce canceration of normal cells and promote tumor angiogenesis and tumor progression.

Therefore, by inhibiting the FGFR signaling pathway, the activity of tumor cells can be inhibited to a certain extent, and it will have a certain therapeutic effect on the treatment of liver cancer.

RET can activate downstream signaling pathways through mutations or chromosomal rearrangements to promote tumor cell proliferation.

Second-generation multikinase inhibitors can also directly inhibit tumor cell proliferation by blocking RET phosphorylation.

Lu Liang picked up the express and trotted all the way to the roadside, preparing to pick up a small electric donkey and drive back to the laboratory building.

However, just as Lu Liang took out his mobile phone and lowered his head to sweep the e-mules parked on the roadside, he suddenly noticed from the corner of his eye that a car was firmly blocking the road in front of him.

Lu Liang looked up and found a black Porsche.

Lu Liang didn't pay much attention. Just as he was about to get on the little electric donkey, a voice sounded.

"Hey, classmate, may I ask how to get to the seventh teaching building?"

The Porsche window rolled down, revealing the face of a young woman, about 24-[-] years old, with satin lipstick on her lips, which was as bright as red plums on the snow.

She was holding the steering wheel with one hand and resting her hand on the car window. Her neat shoulder-length hair and a pair of large-rimmed sunglasses gave this person a somewhat sassy temperament.

Lu Liang glanced at the woman and thought in his mind, isn't the seventh teaching building the teaching building of their pharmacy school?

"Go straight ahead for 200 meters, turn left for 30 meters, then turn right for 547 meters, then turn right at the end for 25 meters, and finally turn left for 100 meters. This is the 30-meter-high building."

Considering that the other party might be a relative of a certain professor, Lu Liang gave a very detailed route.

But this can make women stupid.

Lu Liang's route was indeed very detailed, but the problem was that she couldn't remember things like turning left and right.

The woman simply said: "Classmate, why don't you get in the car and I'll take you to where you want to go first, and then you tell me where the seventh teaching building is?"

"can."

Lu Liang didn't refuse. Why not take a ride if he could get a ride? Anyway, he happened to be going back to the study room.

So Lu Liang simply got into the passenger seat.

The woman asked: "Classmate, where are you going? I'll take you there first."

Lu Liang replied: "No need, I'm going to the seventh teaching building as well, just on my way."

After hearing Lu Liang's answer, the woman was surprised: "Classmate, are you a student at the School of Pharmacy?"

Lu Liang nodded and replied, "Yes."

The woman nodded slowly, and then said: "My name is Yang Qing. I just returned from studying abroad and graduated from graduate school. I currently work in a pharmaceutical company."

Yang Qing showed a smile: "In a sense, the two of us may be peers in the future."

However, after Lu Liang heard these words, he couldn't help but frown.

A person who has just graduated may not be able to afford a car as expensive as a Porsche, right?
Lu Liangliang pondered, and he estimated that Yang Qing's identity might not be simple.

(End of this chapter)