Xueba’s medical black technology system

Chapter 193 The best way to deal with liver cancer is to starve him to death!
After several people from the pharmaceutical company left, only Lu Liang and Chen Shen were left in the conference room.

Lu Liang also stood up and was about to leave. After Chen Shen hesitated for a moment, he finally spoke: "Xiao Lu, are you really sure about this matter within a month?"

Drugs used to treat liver cancer are different from those used to treat other cancers.

The idea of ​​​​other cancer treatments is to target cancer cells and kill them, then the treatment is completed.

But liver cancer is different. Targeted drugs for liver cancer cannot kill cancer cells.

Even these drugs do not have any killing effect on cancer cells. These drugs use new methods to treat liver cancer.

This undoubtedly makes drug development more difficult.

Moreover, even if Lu Liang never fails, animal testing also takes time. If calculated so carefully, one month is really a bit long.

But Lu Liang didn't have too much worry about this. He said, "Suo Chen, I think one month should be enough."

Seeing that Lu Liang was so confident, Chen Shen said nothing more: "Okay, I understand. If you need any help, please contact me in time."

Lu Liang nodded and left the research institute.

After returning to school, it was already past six o'clock in the afternoon. Lu Liang did not go back to the dormitory, but walked directly to the study room.

One month is indeed enough for Lu Liang, but this is on the premise of not wasting time.

If you delay, let alone a month, another month will not be enough.

When passing by the canteen, Lu Liang grabbed a meal from the canteen and then came to the study room.

Because it was meal time, most people had already gone to eat, so there were not many people in the study room.

Lu Liang turned on the computer, and while grabbing the food, he searched and downloaded literature research on liver cancer on the Internet.

Before downloading, Lu Liang did a simple screening of the searched documents. The documents were published in the past ten years, and the publications were searched in the second area or above.

Ultimately one hundred thousand results were left.

To Lu Liang's surprise, among these published documents, judging from the authors and publishing units of the documents.

Nearly half of the studies are from domestic research.

However, this is also understandable.

In fact, as the country with the largest number of liver cancer patients in the world, liver cancer ranks firmly second among domestic male cancer patients.

The reason for this is first of all the "wine table culture" that is far ahead.

Heavy drinking can cause damage to liver cells and induce alcoholic fatty liver. With the development of alcoholic fatty liver, cirrhosis is inevitable, and the final result of cirrhosis is naturally liver cancer.

Of course, if it were just a "wine table culture", the number of liver cancer patients would not be so large.

Another culprit that truly makes the number of liver cancer patients in China rank first in the world is viral hepatitis.

Hepatitis B and C!
More than ten years ago, hepatitis B was something that made people talk about it. In that era without drug treatment, people's fear of hepatitis B was deeply rooted in their bones.

It was not until the emergence of the hepatitis B vaccine that this fear was alleviated.

But even so, there is still no treatment for hepatitis B that can completely solve the problem.

Viral hepatitis is another major culprit in inducing liver cancer. Even in the medical community, viral hepatitis is called the "catalyst" of liver cancer.

Data show that more than 30% of liver cancer patients have a history of chronic hepatitis.

Lu Liang cleaned out the last bite of rice in the bowl, and then threw the disposable lunch box into the trash can.

Before returning to the computer again, Lu Liang glanced at the download progress. Most of the documents had been downloaded.

Lu Liang began to read these documents carefully.

Liver cancer is different from other cancers. The tumor formed by liver cancer is a typical rich blood vessel tumor!
What are hypervascular tumors?
First of all, we have to mention the special characteristics of the liver.

As an important metabolic factory of the human body, the liver carries out many functions such as detoxification, blood coagulation, decomposition, synthesis and storage of glycogen.

This results in the presence of abundant blood vessels and vascular branches in the liver.

It is precisely because of these abundant blood vessels and blood vessel branches that liver cancer cells secrete a substance called vascular endothelial growth factor (VEGF).

This factor, called vascular endothelial growth factor, promotes the formation and differentiation of blood vessels.

This enables intensive and rapid angiogenesis in tumor tissue, and also facilitates the migration and proliferation of liver cancer cells.

This is a hypervascular tumor.

Therefore, for this kind of hypervascular tumor, people have proposed an extraordinarily novel treatment method—starving the tumor to death!
Human beings are living creatures and must rely on the intake of nutrients every day to maintain the basic activities of life.

To put it simply, if you don’t eat, you will die.

Tumor is a part of living things, and it also needs nutrients to maintain the proliferation and growth of tumor tissue.

Without nutrients, tumors will die.

Tumors rely on blood in blood vessels to transport nutrients to proliferate.

Based on this, as early as 1971, Professor Folkman of Harvard Medical School proposed the famous "starvation tumor therapy" theory.

That is, by blocking the formation of new blood vessels in tumor tissue, the supply of nutrients to tumor tissue is cut off.

Without the supply of nutrients, tumors cannot continue to proliferate rapidly.

Thus achieving the purpose of inhibiting and treating tumors.

This treatment method has been applied to liver cancer and has achieved good results so far.

This means that liver cancer treatment cannot start from the cancer cells themselves, but needs to start from the study of angiogenesis.Lu Liang quickly transformed his ideas and began to read some research on blood vessel production.

The process of angiogenesis is also extremely complex. First, endothelial cells receive signals from vascular endothelial growth factors and are activated under the stimulation of growth factors.

Subsequently, the extracellular matrix at the vascular site changes, the basement membrane degrades, and endothelial cells proliferate and migrate.

After endothelial cells complete proliferation and migration, new endothelial cell cords form tubular capillary loops and lumens.

Finally, pericytes gather into capillaries, stabilize the newly formed capillary network, and ultimately form mature blood vessels.

In the entire process, the most important thing is vascular endothelial growth factor VEGF.

Therefore, in a sense, the drug target for liver cancer is the vascular endothelial growth factor VEGF.

To take the simplest example, sorafenib produced by Bayer is currently used as a first-line anti-liver cancer drug.

The drug works by inhibiting VEGFR and PDGFR, blocking the formation of new blood vessels in tumors.

Thereby indirectly inhibiting the growth of tumor cells.

Coincidentally, revafenib, which is used in second-line treatment, also promotes angiogenesis signaling pathways by inhibiting VEGFR1/2/3, etc., thereby achieving the purpose of inhibiting tumors.

In addition, there are lenvatinib, cabozantinib, ramucirumab and other drugs, which all belong to a class of anti-angiogenic drugs.

It can be said that inhibiting the formation of new blood vessels in tumors is the current mainstream idea in the treatment of liver cancer.

After having an idea, Lu Liang was no longer vague.

[Level: lv5]

[Analysis object: Sorafenib]

[By inhibiting vascular endothelial growth factor and platelet-derived growth factor receptor, it blocks the formation of tumor new blood vessels and indirectly inhibits the growth of tumor cells. 】

[Source points required for analysis: 2.5]

[Existing source point: 6.7]

[After analysis, a multi-target liver cancer treatment drug can be obtained. 】

[Start parsing? 】

Lu Liang didn't think much and directly chose to analyze.

In an instant, a large amount of information about drugs poured into Lu Liang's mind, such as synthesis routes, principles of action, drug targets, etc. These contents were sorted out by Lu Liang quickly.

Then, Lu Liang breathed a long sigh of relief and his eyes became brighter.

He quickly opened ChemDraw and started drawing on it.

After one o'clock in the morning.

Not long after Tian Li fell asleep, as the manager of the company, Tian Li had to do a lot of things every day.

In addition to being responsible for the daily management of the company, he also needs to consider research and development matters.

He has now recruited a group of R&D teams.

Of course, this research and development does not refer to the research and development of new drugs. With Lu Liang here, he would not do such a thing foolishly.

This R&D team is mainly engaged in the optimization of drug synthesis routes.

Take the hypoglycemic drug metformin, for example. Although the synthesis route given by Lu Liang is pretty good, the cost of synthesizing the entire drug is about ten yuan per bottle.

But after optimization, through the addition of some catalysts and the substitution of some raw materials.

The cost of a bottle can be controlled at about five yuan.

In this way, the company's profits can be increased.

This is something Tian Li has no choice about. After all, the pricing power of the drug is in Lu Liang's hands, and it is certainly impossible for him to change it without Lu Liang's consent.

The only thing he can do to increase profits is to think of ways to reduce costs and deduct a little profit.

"Jingle Bell"

Not long after Tian Li fell asleep, he was woken up by the ringing of the phone. Tian Li got up from the bed impatiently. It was already this hour. Who was calling?
Even if something happens, can't we call again tomorrow?
Tian Li picked up the phone with some displeasure. However, when he saw the phone number on the phone, Tian Li couldn't help but froze for a moment, and most of his anger dissipated at this moment.

He quickly answered the phone and asked, "Mr. Lu?"

Lu Liang's voice came from the other end of the phone: "Tian Li, it's already o'clock, am I not disturbing you?"

"No, no, don't bother, don't bother."

Tian Li immediately said: "Mr. Lu, this is the time. Is there anything urgent?"

Lu Liang replied: "It's a little urgent. I've sent the stuff to you. I have to trouble Mr. Tian about the drug samples."

Only then did Tian Li notice the document Lu Liang sent to him.

Tian Li said: "No problem, how long will it take?"

"The sooner the better, it's urgent." Lu Liang answered.

This made Tian Li's heart tighten: "Okay, I understand."

After hanging up the phone, Tian Li glanced at the document sent by Lu Liang. After hesitating for a moment, he picked up the phone and dialed another number.

(End of this chapter)