Xueba’s medical black technology system

Chapter 184 It’s over, I’ve become a clown!

There was dead silence in the entire lecture hall.

Ji Hong's expression turned cold when he heard Brennan's question.

He naturally knew what would happen if Lu Liang could not answer this question.

Ji Hong is also ready. If Lu Liang really can't answer the question later, he, as the mentor, will answer the question on Lu Liang's behalf.

This is the safest method.

Of course, it would be better if Lu Liang could answer it himself.

Thinking of this, Ji Hong subconsciously looked towards the stage.

At this moment, Lu Liang was standing on the stage, his expression did not change much, and he was even a little stunned.

At first glance, it seemed that he was confused by Brennan's question and didn't know how to answer it for a while.

In fact, only Lu Liang himself knew that Brennan's question made him think of another thing.

At this time, whispers began to sound in the audience. The scholars in the audience did not know what Lu Liang was thinking.

In their opinion, Lu Liang was already confused by the question.

And Brennan couldn't help but raise the corners of his mouth. This was the effect he wanted.

Just when everyone thought Lu Liang couldn't answer, even Ji Hong was about to stand up and answer the question on Lu Liang's behalf.

Lu Liang on the stage breathed a long sigh of relief, as if he had figured something out, and said slowly: "Professor Brennan, first of all, I have to thank you."

As soon as these words came out, everyone present was stunned. They didn't understand why Lu Liang said such words.

You know, Brennan's question was driving Lu Liang to death. If it were other scholars, they would have said harsh words to him.

But Lu Liang not only did not do this, but instead thanked him. The authenticity of this move made other scholars a little confused.

Not only the scholars present, but also Brennan himself was stunned for a moment, and a bad premonition came to his mind.

And their doubts were quickly explained.

Lu Liang slowly said: "Your question just now gave me a little inspiration, but I'll answer your question first."

As soon as these words came out, Brennan's smile stiffened slightly.

Everyone present suddenly had a look of astonishment on their faces. They didn't expect that at this time, Lu Liang would still be thinking of other things.

Lu Liang ignored the reactions of others and said, "When talking about the mechanism of drugs, the first thing to talk about is naturally the structure of monoclonal antibodies."

"The drug molecular structure of the PD-1/TIGIT inhibitor is a grafted structure, and its drug molecular structure is composed of a CDR1, CDR2, and CDR3 region."

“其中对免疫检查点PD-1的抑制，是通过其分子结构中其较长的CDR3区域识别PD-1的前β折叠面，两者之间共形成了7个氢键和2个离子键。”

"The CDR3 region is rich in aromatic amino acids, which form multiple intermolecular π-π and cation-π interactions with PD-1, thus blocking the PD-1 pathway to exert a therapeutic effect."

"The inhibition of the TIGIT immune checkpoint is through another part of the drug's molecular structure, two important amino acid residues in the CDR1 region and CDR2 region, that bind to the TIGIT immune checkpoint."

Lu Liang spoke quickly about his research on the stage. After figuring out that matter, his thinking became extremely clear.

He didn't even need to think too much at this time, he only needed to think about how to fully express the content in his mind in words.

At this moment, the entire lecture hall was already silent, with some people frowning and thinking about something.

Some people looked confused, obviously unable to keep up with Lu Liang's thoughts, and finally had no choice but to give up and stand there staring.

After all, if you can't keep up with the train of thought, there is no point in continuing to listen.

Not only the scholars in the lecture hall, but also the review experts sitting in the front row are also thinking.

Among them was Donaldson, a professor at Massachusetts General Hospital, but he was frowning at the moment, trying hard to digest what Lu Liang said.

Then, he seemed to realize something, and turned to look at Azzoli, who was a distance away from him, and Azzoli seemed to be looking over with understanding.

Donaldson said, "Structural physiology?"

Azzoli nodded: "If I understand correctly, this antibody structure is completely designed for the two immune checkpoints of PD-1 and TIGIT."

Donaldson was silent for a while: "In other words, the structure of this antibody is destined to preferentially bind to immune checkpoints in cells, thereby quickly exerting an inhibitory effect rather than producing other effects."

"Even if it produces other effects, it is only an extremely small effect and cannot play a real decisive role."

Azzoli said with a wry smile: "Explanation from the molecular structure is indeed the best way. At first, I thought that to explain Brennan's problem, a batch of in vitro cell experiments might be needed, etc. Only with experimental data can we explain this problem."

Donaldson couldn't help but be speechless: "This is probably the way most people think."

Azzoli then looked at the stage and said, "Actually, the content of the story up to this point can completely answer Brunan's question."

Donaldson couldn't help but sigh: "This research is deeper than imagined."

Both of them are masters in the field. They don't need to elaborate too much. A simple sentence or two is enough to make the other party understand what they mean.The explanations and comments given by Azzoli and Donaldson were quickly told to others by nearby scholars who heard them. They were spread from one person to another, and soon everyone knew about it.

Naturally, other scholars also believed deeply in the explanations and evaluations given by the two extremely authoritative people in the entire conference.

This also made the scholars in the lecture hall look amazed, especially Ji Hong. After hearing Lu Liang's answer, he also breathed a sigh of relief, and a big stone fell in his heart at this moment.

Finally, after Lu Liang on the stage finished explaining, he looked at Brennan in the audience and said, "Professor Brennan, I said this, can you understand it now?"

As Lu Liang finished speaking, everyone present looked at Brennan, who was standing in the crowd, looking extremely awkward.

With Brennan's level, he can naturally understand Lu Liang's explanation, and it is precisely because of this that Brennan is already a little irritable at this moment.

He originally thought that Lu Liang couldn't answer this question at all.

To be more precise, his thinking was the same as Azzoli's. He believed that Lu Liang needed to produce a batch of in vitro cell test data to explain his problem.

A batch of experiments cannot be completed in a short time, which is why he expected Lu Liang to be unable to answer.

But he never expected that Lu Liang would use tricks to explain it from the molecular structure.

This frustrated Brennan's calculations.

Of course, what makes Brennan feel the most uncomfortable is that at this time, no matter how unhappy he is, he can only force a smile on his face: "Thank you so much. This doubt has been bothering me for a long time."

After all, he was the one who asked the question. Lu Liang answered his question, so he must be grateful.

You know, so many scholars are still watching, unless he gives up.

However, in response to Brennan's thanks, Lu Liang just waved his hand and said with a smile: "Professor Brennan, don't be in a hurry to thank me, we have just begun."

Hearing Lu Liang's words, Brennan was stunned, and he frowned almost subconsciously.

He really didn't understand what Lu Liang meant. Lu Liang had already thoroughly explained his question. Is there anything else he could say?
Not only Brennan, but other scholars present were also confused for a moment, not understanding what Lu Liang wanted to do next.

Lu Liang explained at this time: "Professor Brennan, I said before that your question gave me a little inspiration. PD-1/TIGIT inhibitors can be more than just PD-1/TIGIT inhibitors."

“CD47、CTLA-4、CD155、Tim-3、LAG-3、Galectin-9我想已经足够了！”

Lu Liang began to read out words one by one as if spitting out beads.

When Lu Liang first started reading, the scholars present had not yet reacted.

But when Lu Liang was halfway through reading, those scholars who were engaged in research on cellular immunotherapy immediately reacted.

What Lu Liang read out were the names of immune checkpoints. These immune checkpoints more or less have the function of regulating immune killing and prompting immune cells to kill tumors.

You must know that everyone present is a well-known scholar outside. It can be said that anyone who has reached this point cannot be a fool.

Therefore, they understood what Lu Liang meant in an instant, and the moment they understood Lu Liang's thoughts, their breathing suddenly became rapid.

"If we can imitate its molecular structure, we can create a monoclonal antibody that simultaneously inhibits CD155 and Tim-3, two immune checkpoints."

"There is also CTLA-4, a cytotoxic T lymphocyte antigen. Many studies have proven that CTLA-4 is no less effective than PD-1, and it has monoclonal antibodies that inhibit CTLA-4 and PD-1!"

"The outlet is the new outlet!"

"How fruitful this can be!"

Some scholars blurted out excitedly and subconsciously, some scholars' eyes lit up, and some even quietly left the scene.

Now that everyone knows this, we must race against time.

After all, whoever does it first will get the result!
While many scholars were excited, there was only one exception.

This person is Brennan.

Brennan's face looked very ugly at the moment.

After hearing the names of these immune checkpoints, he instantly understood what Lu Liang was talking about.

However, he was a little confused as to why Lu Liang shared this inspiration. Shouldn't he keep this good idea secretly?
However, when he saw a reporter next to him pointing the camera at him, Brennan's heart suddenly thumped.

At that moment, Brennan suddenly understood why Lu Liang wanted to publish this good idea.

Today's conference is destined to be reported by reporters and spread throughout the academic circle.

And his name, Murray Brennan, and what he did at this conference will also be reported.

If he failed to make things difficult for himself, it would actually provide inspiration to Lu Liang. It would then be known to all scholars in the field and become a hot topic in the circle.

Lu Liang succeeded. Not only did he successfully answer his tricky question, but he also stepped on him hard.

This kick will become an indelible stain on his academic career.

Thinking of this, Brennan's face suddenly turned pale.

It's over, I've become a clown!
(End of this chapter)