Xueba’s medical black technology system

Chapter 139 The brain is forced to shut down
immunity therapy.

This is a medical concept born in the last century, discovered as early as the 19s by cancer immunotherapy pioneer William Coley.

A patient with malignant sarcoma was unfortunately accidentally infected with Streptococcus pyogenes during surgery.

In the absence of antibiotics, patients can only rely on their own immunity to fight germs.

After experiencing several high fevers, the patient's streptococcal infection went into remission and his malignant sarcoma was cured.

After William Coley discovered this, he realized that the immune system was far more powerful than imagined.

Therefore, William Coley began to use streptococcal infection to treat malignant sarcoma.

Officially launched the first of its kind in human tumor immunotherapy.

In 1984, Rosenberg used IL-2 to cure melanoma patients in a clinical trial, demonstrating that the immune system could indeed curb tumor development.

Later, Rosenberg pioneered LAK cell therapy and TILs cell therapy.

Proving that the immune system plays an unshakable role in cancer treatment.

Research on immunotherapy has officially begun.

Finally, as time came to 1992.

Professor Shuyou discovered PD-1!

PD-1, an immune checkpoint.

There is a T cell in the body, called a T lymphocyte. T lymphocytes kill infected or mutated cells, causing infected and mutated cells to self-destruct.

But in order to prevent T lymphocytes from killing red eyes, normal cells are also killed.

So there is PD-1. This protein is used to regulate the killing power of T lymphocytes and prevent T lymphocytes from killing normal cells.

Tumors produce a PD-L1 ligand protein that binds to PD-1, thereby inhibiting the killing of T lymphocytes.

Allow tumor cells to evade detection and attack by the immune system.

If the activation of immune checkpoints can be inhibited, the pathway can be effectively blocked and tumor cells can be effectively killed.

Therefore, after research by major pharmaceutical companies, PD-1 inhibitors soon came out.

BMS’s Opdivo, the famous O drug, and MSD’s Keytruda, the so-called K drug.

And what about T medicine, B medicine, etc.

These are all PD-1 inhibitors.

Lu Liang quickly searched the literature and carefully read all the studies on tumor immunotherapy.

At the same time, Lu Liang was quickly sorting out various information in his mind.

Tim-3, LAG-3, CD47, PD-1
These are immune checkpoints that are associated with lung cancer.

The veins on Lu Liang's forehead bulged, and his breathing became heavier, like an old ox pulling a plow.

At this moment, there is less than 5 minutes left for the second overclocking capsule.

But Lu Liang is still rapidly screening various immune checkpoints.

CTLA-4, Galectin-9, CD155
Lu Liang's eyes were bloodshot, and the continuous overclocking made his brain feel like an engine that was severely overloaded and about to explode.

But Lu Liang ignored it. He still chose to step on the accelerator. He needed to find the final answer in these last few minutes.

In the last few seconds approaching the timeline.

Lu Liang's eyes suddenly lit up, and he seemed to have discovered something.

TIGIT!

That’s right, it’s TIGIT!

"Hey, I found you!"

Lu Liang let out a strange laugh.

As soon as Lu Liang finished speaking, there was a "bang", Lu Liang's eyes darkened, and he fell down on the table.

The brain is forced to shut down.

in the office.

Ji Hong looked at Wang Wentao with some surprise: "You want to enter the laboratory?"

Wang Wentao nodded: "But Senior Brother Lu said to let me wait for a few days, and then he would take me into the laboratory. But it has been almost a week now, and there is still no movement from Senior Brother Lu."

After thinking for a moment, Ji Hong asked: "Have you contacted Xiao Lu?"

"I sent a message to Senior Brother Lu, but he didn't reply to me." Wang Wentao said a little uneasily.

After listening to Wang Wentao's words, Ji Hong frowned slightly.According to Lu Liang's character, Lu Liang would definitely reply after seeing Wang Wentao's message.

If there is no reply, it can only mean that Lu Liang has not seen the message at all.

Is it because you are busy with something?

Ji Hong started to think about it. In fact, he hadn't heard much from Lu Liang since he came back from the hospital last time.

Therefore, Ji Hong didn't know what Lu Liang was doing.

After hesitating for a moment, Ji Hong said: "Let's do this, Wen Tao, if we just wait a day or two, it won't work. I'll find someone to take you to the laboratory and teach you some basics."

"Okay, thank you teacher."

After Wang Wentao left the office, Ji Hong thought for a moment, then picked up his cell phone and dialed Lu Liang's number.

But there was no answer on the other end of the phone.

This made Ji Hong even more confused, but he could only put down his phone temporarily.

Lu Liang did not sleep until he woke up naturally.

To be more precise, he was awakened by pain.

As his senses gradually recovered, the first thing Lu Liang felt was fatigue, and the feeling of being hollowed out was particularly strong.

But then, the feeling of exhaustion was instantly overwhelmed by pain, causing Lu Liang to take a breath of air.

Headache.

Calling it a pinprick-like pain is an understatement.

Lu Liang felt as if his brains had been dug out. He then smeared a layer of chili powder on it, and then he was thrown into the stone trough and hit hard with a sledgehammer several times to allow the chili powder to fully mix with the brains. Evenly.

Finally stuffed it back into him.

Especially the blood pressure pain, it feels so obvious that my eyes feel like they are about to bulge out.

"Hey, Lao Lu, wake up."

Lu Liang heard Cheng Ming's voice in a daze.

But Lu Liang couldn't care about anything else at the moment. He said in a hoarse voice: "Ibuprofen, give me ibuprofen quickly!"

Soon, Lu Liang felt a glass of water and a pill handed to him.

Lu Liang picked up the water and medicine and drank it in one gulp, then lay down heavily.

I don't know if it was because of psychological effects, but after taking the medicine, Lu Liang felt that the pain seemed to have weakened a lot.

Ibuprofen saved my dog’s life!

Lu Liang couldn't help but let out a long sigh of relief.

After feeling gradually better, Lu Liang looked around and realized that he had been lying on the bed for some time.

In Lu Liang's last memory, he remembered that he clearly collapsed in front of the table.

At this time, Cheng Ming spoke: "Lao Lu, what were you doing last night? You fell asleep on the table and you couldn't wake up no matter how you screamed."

"We had a hard time getting the bed into bed."

After listening to Cheng Ming's words, Lu Liang suddenly smiled bitterly.

To be honest, he still underestimated the side effects of overclocking capsules.

As soon as the effect of the overclocking capsule ended, his brain was forced to shut down without giving him any time to react.

However, this has nothing to do with others, it mainly has to do with his own chaos.

For the brain, the burden brought by one overclocking capsule is already large enough, and he knocked on two overclocking capsules in a row.

His brain immediately gave him a break.

It seems that I still can't be so messy in the future, otherwise my brain will be damaged sooner or later.

Then, Lu Liang remembered something and asked, "Old Cheng, how long have I been asleep?"

"You have been sleeping since we came back yesterday, and you have been sleeping until now."

Lu Liang carefully estimated it. According to Cheng Ming, he must have slept for almost 24 hours.

So if you think about it, the headache will last for another day.

Then we can only continue

(End of this chapter)