Xueba’s medical black technology system

Chapter 115 What you can’t do, I’ll do it
If the development of antiviral drugs was really that easy, would they still need Lu Liang’s reminder?
They have already developed antiviral drugs themselves.

Anyone who knows a little bit about viruses would not be able to speak out as easily as Lu Liang!

The professor looked at Lu Liang with a slightly sarcastic expression: "I would like to ask, student Lu Liang, do you know about this hepatitis C virus?"

Faced with the professor's question, Lu Liang said calmly: "I didn't understand it before, but I learned a little bit about it on the way here."

"Pfft, hahaha!"

This time, these professors could no longer hold back and laughed out loud.

Ji Hong on the side couldn't help but frown after seeing this scene.

"Professors, please be careful about your words and deeds."

These professors also knew that their current behavior was not consistent with their status. After taking a few deep breaths, they stopped the smiles on their faces.

One of the professors also waved his hand and said, "Sorry, it's our problem. We couldn't hold it back. Mainly because we didn't expect Lu Liang to be quite humorous."

Lu Liang ignored it and said calmly: "I think it's almost enough. Is there any problem?"

One of the professors named Zhao smiled and said: "Lu Liang, let me ask you the simplest question, how much do you know about the etiology and epidemiology of hepatitis C virus?"

As the professor's words came out, several others snickered.

Professor Zhao's question is as simple as a basic concept for researchers in the field of virology, but for people who know virology, it will be completely confusing.

Especially Wang He, who was lying on the chair with his arms folded, as if he didn't mind the joke.

Chen Shen couldn't help but get a little angry when he saw this scene. His purpose of holding this meeting was to find a plan that everyone could accept.

But now, this group of people had their sights on Lu Liang and planned to solve the problem directly by forcing him into prostitution.

Lu Liang replied calmly: "Hepatitis C virus, which was identified using current molecular cloning technology in 1989, belongs to the Flaviviridae family."

"The genome is a single-stranded positive-stranded RNA structure, 50 nanometers in size. Different from the double-stranded DNA of hepatitis B virus, the single-stranded RNA of hepatitis C virus is unstable and prone to mutation."

"There are 6 genotypes of hepatitis C virus. Among them, type 1b and type 2a are mainly prevalent in China. I'm right, Professor Zhao."

Regarding Lu Liang's answer word for word, Professor Zhao raised his eyebrows: "Hey, you can see that our classmate Lu Liang has done the most basic homework."

Although Professor Zhao said this, the teasing look on his face remained unabated.

From their point of view, this is just some basic common sense, and they can find it even with just a quick search.

Therefore, even if Lu Liang answers, so what, it doesn't explain anything at all.

If Lu Liang wants to develop drugs based on this, it is undoubtedly a fantasy.

Therefore, Professor Zhao and others still did not take Lu Liang to heart.

Lu Liang ignored Professor Zhao's words and continued: "The current mainstream treatment for hepatitis C patients is ribavirin + interferon."

"Ribavirin is a nucleoside antiviral drug. It can enter cells parasitized by viruses, block the synthesis of viral RNA and proteins, and inhibit the growth and spread of viruses."

"Interferon can effectively bind to specific receptors on the cell surface and block the combination of hepatitis C virus and ribosomes, thereby controlling virus replication."

"The two drugs work together to achieve the goal of curbing virus replication to the greatest extent."

"I'm right, Professor Zhao!"

Lu Liang's words are as sharp as a knife.

As Lu Liang finished speaking, at that moment, the atmosphere in the conference room became visibly tense.

Under Lu Liang's gaze, Professor Zhao felt a tingling sensation on his back, as if he was sitting on pins and needles.

Professor Zhao narrowed his eyes slightly, put away the smile slightly, and the expression on his face became tense.

Not only Professor Zhao, but also several other professors in the conference room could not help but restrain their smiles, and they all focused on Lu Liang.

They realized that Lu Liang was not as simple as he thought.

Professor Zhao opened his mouth. He was about to say a few words to build up his momentum, but before he could speak, he was interrupted by Lu Liang.

Lu Liang continued: "The hepatitis C virus genome encodes structural proteins and non-structural proteins. The structural proteins make up the outer membrane and nucleocapsid. The nucleocapsid is necessary for the replication of hepatitis C virus."

“非结构组蛋白有包括蛋白和解螺旋酶NS2、NS3、NS4A、NS4B，RNA结合蛋白NS5A，RNA聚合酶NS5B。”

"The enzymes and proteins required for the replication of these viruses are the drug targets of hepatitis C virus."

"I'm not wrong, Professor Zhao! Professor!"

Lu Liang said the last sentence word by word. His eyes were fixed on Professor Zhao, with murderous intent as clear as a hawk.

At that moment, the atmosphere in the entire conference room suddenly became extremely depressed.

Several professors present had Adam's apples rolling. They wanted to interrupt Lu Liang, but they found that there was a stone in their throats and they could not speak at all.

Or rather, it’s impossible to refute!

Because everything Lu Liang said is right!

Especially Professor Zhao, his expression was stiff at the moment, his face was red, and veins popped out at his temples.

Lu Liang's words were like slaps on his face, but he had no way to refute.

He knew very well that some of what Lu Liang mentioned, especially those drug targets, already involved cutting-edge science, which meant that they were just theories but could not be realized with technology.

Didn’t you say that we just wanted to know a little bit about it on the way here?

You call this, just a simple understanding?
Professor Zhao couldn't help but roar in his heart.

At this moment, Professor Zhao was filled with regret. He was completely embarrassed this time. If he knew that Lu Liang knew so much, he would not be stupid enough to say something rude.

但此刻，陆良再一次开口：“施贵宝公司的百立泽分子式C40H50N8O62HCl，其药物靶点为NS5A，因此属于NS5A蛋白抑制剂。”

"The molecular structure of its drug can interact with the amino terminus of the protein region 1 of the hepatitis C virus, which can cause structural distortion and interfere with the function of NS5A."

"Thereby achieving the purpose of inhibiting viral RNA replication and virus particle assembly, and curbing virus replication!"

"What I said is right, Professor Zhao! Professor!"

Lu Liang's words are heart-breaking.

Dense beads of sweat appeared on Professor Zhao's forehead. Beads of sweat as big as soybeans rolled down from Professor Zhao's forehead, and his back was soaked with cold sweat.

Wrong, right, wrong, right?
How did he know!

Although he is doing research on liver disease viruses, he mainly focuses on hepatitis A and hepatitis B.

Although he has done research on hepatitis C, he has never gone that far.

He himself didn't know what Lu Liang said was wrong!
Professor Zhao suddenly felt an overwhelming pressure coming towards him.

Professor Zhao subconsciously looked at the other professors, wanting to ask the other professors to block him.

But after Professor Zhao saw the expressions of several other professors, he was immediately dumbfounded.

I saw that several other professors had lowered their heads at this moment and were silent.

At that moment, he seemed to be helpless in the vast ocean.Professor Zhao couldn't care about anything else at the moment. If he continued like this, he would be completely disgraced. He would never be able to see anyone in the academic circle in the future.

Professor Zhao gritted his teeth and said, "So what, even if you know this, so what."

"You are not the only one who knows these things, but with so many people, how many of them have found working drug molecules?"

"You can't find any drug molecules that work, so your words are just words on paper!"

Professor Zhao banged the table.

Knowing that and being able to do it are two different things.

So what if Lu Liang knows, this is not mathematical physics, just prove it. This is medicine, you have to screen out a compound that meets your idea from billions of compounds.

Finding a needle in a haystack is the best word to describe it.

Thinking of this, Professor Zhao looked at Lu Liang with a sneer again.

As Professor Zhao said this, several other professors also nodded.

"Yeah, the key is to find the drug molecules that work."

“There are so many studies published every year, and the stuff is out there for everyone to read, but how many people can do it?”

"Theory is theory and must be separated from reality."

Facing the discussion of several professors, Lu Liang just replied calmly: "When did I ever say that I couldn't find it?"

As soon as these words came out, a look of astonishment appeared on everyone's face, except Ji Hong.

Professor Zhao's Adam's apple rolled, and his expression was full of disbelief: "You mean, you can find a drug molecule that inhibits the NS5A protein?"

Lu Liang said lightly: "Not enough. One drug molecule that inhibits NS5A protein is not enough."

"Then what do you want to do?" a professor asked with a trembling voice.

"One drug molecule that inhibits the NS5A protein does not address six different genotypes of hepatitis C virus."

Lu Liang glanced at the professors, then took a deep breath and said, "What I want is a drug that can solve 6 different genotypes of hepatitis C virus at once!"

As Lu Liang finished speaking, Professor Zhao stood up suddenly.

"Impossible, this is absolutely impossible!"

It's difficult enough to find a drug molecule that works against the hepatitis C virus, let alone one that can tackle six different genotypes of the virus at once.

"This kind of thing should be done down-to-earth and step by step."

"You can't become fat in one bite, and you can't eat hot tofu in a hurry."

Several professors shook their heads.

In their view, Lu Liang's words were undoubtedly fanciful and wishful thinking.

"What if it's a combination of NS5A protein inhibitor + NS5B polymerase inhibitor?"

However, at this moment, Lu Liang suddenly spoke.

Lu Liang's voice was not loud, but every word was like a huge bomb falling, exploding in everyone's ears, and setting off a storm in everyone's heart.

NS5A protein inhibitor + NS5B polymerase inhibitor?

If the two inhibitors are combined, it seems that they can really cover 6 different genotypes of hepatitis C virus.

After realizing this, the expressions on the faces of several professors were horrified.

Even Chen Shen couldn't help but open his mouth, even he felt incredible about Lu Liang's proposal.

At the same time, an idea emerged in Chen Shen's mind.

Can this really be done?

Being able to screen out a drug molecule that is an NS5A protein inhibitor is already remarkable.

But Lu Liang not only needs to screen out drug molecules for NS5A protein inhibitors, but also needs to screen out drug molecules for NS5B polymerase inhibitors.

How much time does this take?

However, at this moment, Wang He, who had been sitting silently next to him, sneered and spoke.

"Then I would like to ask, classmate Lu Liang, how long do you plan to use to screen out these two drug molecules?"

As soon as Wang He's words came out, these professors were instantly awakened.

Yes, this kind of thing cannot be done just by talking about it.

Who doesn’t know how to say such beautiful words? But the problem is that finding drug molecules is your skill!
You know, Bristol-Myers Squibb spent more than ten years just looking for a drug molecule for an NS5A protein inhibitor.

This can only be achieved with the backing of a huge pharmaceutical company, massive funds, technology and the most critical talents.

What Lu Liang now wants to screen out are not only drug molecules for NS5A protein inhibitors, but also drug molecules for NS5B polymerase inhibitors.

This is almost double the workload.

How long will it take to complete such a huge amount of work?
These professors seemed to have grasped Lu Liang's most fatal weakness, and they all rallied to attack him.

"Yeah, don't do it for 20 or [-] years. By then, all hepatitis C patients will have liver cancer."

"In 20 years, the patent for Bristol-Myers Squibb's Bilize drug has expired. We can produce it ourselves, so why do we need your drug?"

"So, this kind of thing is basically whimsical."

After hearing Wang He's words, Chen Shen couldn't help but feel his heart sink. Although these words didn't sound good, they were indeed things that could happen.

Thinking of this, Chen Shen couldn't help but look at Lu Liang.

Faced with the cynicism of the crowd, Lu Liang didn't bother to talk nonsense. He directly stretched out three fingers, his meaning was very clear.

After seeing Lu Liang's gesture, the heartbeats of Wang He and several professors present skipped a beat.

three years?

As long as three years? !
Is this really something that one person can do?

"Three months!"

Lu Liang spat out a few words coldly: "Give me three months!"

At that moment, the entire conference room was deathly silent.

The pupils of Wang He and others trembled crazily at this moment.

Lu Liang's words directly set off a storm in their hearts!

Shock and horror were frozen on everyone's faces, looking extremely wonderful!

(End of this chapter)