Johime Three Kingdoms

Chapter 186 Malaria
Cao Cao looked at Bai Tu's memorial with a somewhat solemn expression.

First, there was an outbreak of malaria in Shouchun - allowing Cao Cao to gloat a little.

As expected, the great sage Bai, who loved his people like a father, his first reaction at this time was to return home and work on the troubles in Shouchun.

However, Bai Tu's reaction afterwards made Cao Cao feel a little uncomfortable...

The seven counties of Yiyang were occupied, and Cao Cao did not expect Bai Tu to return them. Moreover, in name... Bai Tu continued to distribute relief grains in the seven counties for disaster relief. No matter whether he was from these seven counties or not, he would not return it. Can have a full meal.

But considering the counties in Runan, the disaster was not that serious. Even if Yuan Shu was more cruel and had a worse reputation, there should not be many people who would abandon their families and careers to "make a living".

The establishment of Yiyang County and the appointment of Yiyang Prefect were all expected, and although Runan was bitten off a bit, Cao Cao was also very distressed, but... it was just a corner.

What really makes Cao Cao's look a little unnatural is...

"Qing Cheng Zhonglang General? Is this the general title that the unambitious Duke Bai came up with?" Guo Jia said sarcastically.

"Ahem, I was indeed not on guard before..." Xun Yu said with some embarrassment.

"I'm not targeting you, I'm saying... that guy is a liar!" Guo Jia emphasized.

Guo Jia felt aggrieved. If he had known that something like this was going to happen to Shouchun, why would he bother to use the "general trend"?
For an owner of the "Book of Luck", the greatest luxury is lifespan. A slightly advanced level of luck almost requires lifespan as compensation.

Five years after Guo Jia activated the effect, his life span had been shortened for five years. After that... Bai Tu actually turned around and went back?

Fortunately, it was not a one-time payment. After learning the news, Guo Jia also terminated the effect of "the general trend" and stopped the loss in time - the "general trend" can only take effect on the same target at the same time.

"Based on the letter sent before, it seems that General Bai does not want us to accept Yuan Shu's legacy... What do you think?" Cao Cao asked.

Bai Tu not only expressed his denunciation of Yuan Shu's crimes to the court before, but also sent a message to Cao Cao in a private capacity, hoping that he could "turn around and make peace" and give a fair verdict to the participants in the Shouchun disaster!

After that... the generals who were stationed in Yiyang were canonized as "Generals of the Qing Dynasty". This made Cao Cao have to think - is it because I accept the words of those people that you Bai Tu want to come to the "Qing Jun side"?

Obviously it's not just Cao Cao who thinks this way.

After all, the only reason to use troops against Cao Cao is to "clear the emperor's side" when he holds the imperial court and serves as the emperor to command the princes. Unlike Yuan Shu, who severed ties with the Han Dynasty, the only reason for using troops against Cao Cao was.

And with Bai Tu's reputation, after Cao Cao accepted Yuan Shu's surrender, if Bai Tu wanted to "clear the emperor's side", maybe some people would really believe it from the bottom of their hearts... and even more would believe it tacitly.

As for whether this "side" only includes Yuan Shu's surrendered generals, or whether Cao Cao is also included, then only Bai Tu himself has the final right to interpret.

Liu Ye then suggested that the evil leader Qiao Rui and others could be executed to eliminate Bai Tu's excuse.

Of course, this is just an assumption. After all, Qiao Rui is still on the southern front in Runan and has not surrendered to Cao Cao yet!
But at this moment, Yang Xiu, who had just been "employed" into the Sikong Mansion, said, "How can it be that because of Fan Chen's words, he cut off the opportunity to strengthen himself, and his reputation of appointing talents and using talents is damaged? What if? If even the surrendered generals cannot be saved, how can other surrendered generals be reassured?
What's more, even if there is no excuse for the Shouchun incident, can't we use the Xuzhou incident as an excuse?Instead of thinking about how to prevent Duke Bai from conquering in terms of morality, it is better to defeat the opponent in terms of strength. Otherwise, can the lord defeat Duke Bai in terms of benevolence? "

The incident in Xuzhou... "could it" be defeated by benevolence...

Cao Cao felt like he was hit by an arrow in the knee, one on each side!
Seeing the young and energetic Yang Xiu chatting away, many people felt so uncomfortable that they wanted to cover their faces...

Well, in general, what Yang Xiu said makes sense, and his analysis is so insightful. But why does Cao Cao feel so uncomfortable?
Yang Xiu was the son of Yang Biao, the legitimate son of the old lieutenant whom Cao Cao used to find an excuse to be related to the Yuan family, and then had his official post taken away from him and was jailed and beaten severely.

Because of Yang Biao's imprisonment, which shocked Shilin, Cao Cao also decided to hire Yang Xiu to repair the relationship with the old noble family of the Han Dynasty.

And Yang Xiu was not an incompetent person. Cao Cao did think highly of him at this time and entrusted him with the position of "master secretary" - that is, his secretary. At Yang Xiu's age, this was already very rare.

"Ahem, what Dezu said is not wrong. If he is led away by Bai Gong, he wants to kill the Yuan family's surrender today, and tomorrow he asks us to kill General Yuan Rang and General Miaocai. What should we do?" He changed the topic and used the two generals of the Xiahou family as examples.

"Yes, my lord, you must not use your own shortcomings to attack the enemy's strong points." Yang Xiu solemnly concluded.

From everyone's understanding of Yang Xiu, he did not deliberately provoke Cao Cao, but was just "reasoning".

It’s just that Xun Yu didn’t want to answer the conversation.

Cao Cao: ...

"Dezu, I heard that your royal family has forced you to get married recently?" Cao Cao suddenly asked.

"Little things, small things are not worth talking about here." Yang Xiu said nervously.

Yang Xiu was only seventeen or eighteen years old, which was considered a late marriage in the Han Dynasty, but he was not too old among the noble sons of aristocratic families.

Cao Cao really didn't mention this matter again after that, which made Yang Xiu puzzled.

However, in terms of decision-making, Cao Cao and Yang Xiu did think of one thing - they should not give up the opportunity to strengthen themselves just because they were afraid of Bai Tu's excuse for attacking.

……

On the other hand, when Bai Tu led his army back to Shouchun, he found that the city was under complete martial law, and the sick people, whether they were city residents or rural farmers, were concentrated as much as possible around the west gate of Wengcheng.

Naturally, tents are indispensable in the army. Although there is a hint of autumn, it will not make the patients feel cold.

This is also the result of Zhang Zhongjing's command of Shouchun's army and civilians. Lao Zhang was not only a famous "miracle doctor" in the late Eastern Han Dynasty, but compared to another miracle doctor Hua Tuo, Zhang Zhongjing was better at epidemic diseases.

"Nie Yang Zhang Ji, meet Mr. Bai." Zhang Zhongjing was quite respectful when he saw Bai Tu.

After all, when Zhang Zhongjing was the most powerful official, he was only a prefect and could not compare with the generals of chariots and cavalry. More importantly... Zhang Zhongjing admired Bai Tu's benevolence even more.

Of course, it was said that it was a greeting, but it was just a hand-in-hand...

"Doctor Zhang, there is no need to be polite! Fortunately, you are always here, otherwise the people of Shouchun would have suffered from natural disasters after man-made disasters!" Bai Tu said with emotion.

This year's Shouchun is indeed an unfavorable year. Because Yuan Shu finally moved away, the drought was about to pass. It had already rained a little, but the plague came again.

"I don't dare to be called a miracle doctor, it's just my duty as a doctor." Zhang Zhongjing said modestly.

However, Mr. Zhang's moral character is unquestionable - if it were an ordinary person, who would dare to infiltrate wherever there is a plague?

Not to mention ancient times, when modern preventive measures were perfected, the medical workers and rescue workers who dared to go to the epidemic areas were all top-notch and had nothing to say.

Bai Tu also asked Mr. Zhang about the plague...

"First you get chills, then you get fever, and finally your body temperature drops... It's definitely malaria." Bai Tu muttered to himself. It was already called "malaria" in the Eastern Han Dynasty.

"Mr. Bai also knows medical skills?" Zhang Zhongjing asked curiously.

What Bai Tu asked before was indeed very targeted, and Zhang Zhongjing could see that he was not being cryptic.

"I've... read a little bit. Just call me Hard Drive, Mr. Zhang. What does Mr. Zhang think of the malaria in Shouchun?" Bai Tu said modestly. He had indeed seen some, just before he came back.

Zhang Zhongjing showed some embarrassment when he heard this, and then said: "If several people are sick, there is still a cure for the elderly, but...in the past, there were constant man-made disasters and failed to be detected in time. Now the epidemic has spread, making it difficult and difficult to deal with."

Without hiding it from Bai Tu, Zhang Zhongjing told him his prescriptions, one was Shuqi Powder to treat malaria, and the other was Biejiajian Pills to treat sequelae.

The latter is just a supplement, if you don’t have it, it will be gone. Bai Tu really can’t find so many tortoises to boil turtle glue...

However, as a therapeutic drug, the former is urgently needed!

But the medicine is a bit... uncomfortable. The main ingredients of Shuqi powder are Shuqi, dragon bone and mica. The first two are plants, mica is a mineral, and Shuqi... As you can tell from the name, it is a plant from the land of Bashu. , Keel, also known as "Triangle Overlord Whip", is a kind of fleshy meat, native to Lingnan.

Lao Zhang is indeed a miracle doctor of the Eastern Han Dynasty. Even if he encounters a plague, he will not be helpless. But... Now he is going to Yizhou and Jiaozhou to buy Sichuan paint and dragon bones?

You may not be able to get a share of a city in a year!

As for the stocks of each pharmacy?Folk medicine in the Eastern Han Dynasty was not developed at all, with few prescriptions, and Sichuan paint was not popular enough. How could it be obtained at the moment?
Moreover, Zhang Zhongjing did not brag with Bai Tu, and the chance of treatment was not very high.

When it comes to malaria in ancient times, cinchona is more effective in treating malaria, and it’s easy to use—just peel off the bark of the cinchona tree and chew it!
But the problem is... Don't look at the things that were found in Yunnan and Baodao in later generations. They were all transplanted from South America. If you expect South America... you might as well go to Yizhou and Jiaozhou!

A dozen, twenty, or thirty years later, Bai Tu might have some hope of getting a cinchona tree.

However, Bai Tu is not helpless, but... there are difficulties in operation!
Artemisinin, a substance that Ms. Tu has studied for decades and finally won the Nobel Prize for, is the nemesis of malaria.

Moreover, Ms. Tu’s inspiration for researching artemisinin originally came from "Emergency Prescriptions", which means that during the Eastern Jin Dynasty, there were already examples of using artemisinin to treat malaria, but unfortunately it was not common, and... there is a big problem The problem.

The reason why this film revealed the recipe for the killer of malaria more than 1000 years ago, but failed to eliminate malaria, and required Ms. Tu to study it for decades with modern technology, is precisely because of one of the most critical issues - the concentration of the ancient recipe was too low. , the effect is very poor.

The method of "Emergency Prescription" is to squeeze the Artemisia annua raw in water, and then drink it in tons...

It is indeed effective for people with good luck and good health, otherwise it would not be passed down to future generations. However, the cure rate can only depend on fate.

The raw material of artemisinin is easy to find - Artemisia annua.

The "Qinghao" of the Eastern Han Dynasty was the "Huanghao" of later generations.

But extraction is a big problem. First of all, the simplest steaming method will definitely not work, because artemisinin decomposes when heated, and it is better to squeeze it raw than to boil it.

This is why artemisinin is obviously more effective than quinine and has fewer side effects, but with primitive technology, cinchona tree is more effective than artemisia annua...

Later generations can use ether, gasoline, silica gel... But these cold extraction technologies are not available in Baitu, and it is probably too late for Pang Tong to learn them on the spot. After all, many of them require the later technological support in Baitu's plan!

But without further delay, Bai Tu was going to find an excuse to collect a large amount of Artemisia annua, and then contact Pang Tong immediately. It would be best if he could find a way. If there was no other way, he could also deal with the raw Artemisia annua.

I think the malaria parasites from the Eastern Han Dynasty should not be as resistant to antibiotics as those from later generations. At least they are more reliable than Shuqi San, which you can't count on...

(End of this chapter)