A leisurely life reborn in the fiery age

Chapter 304 New Achievements

"Buy us?"

The weather in Hong Kong Island in April was over 20 degrees, which was relatively comfortable. Li Yuan met Michael Kadoorie and An Wenchao, general manager of the pharmaceutical factory, who had come together at the entrance of the pharmaceutical factory's laboratory. He said speechlessly: "What nonsense are you talking about?" , called me out of the laboratory for this little thing?"

An Wenchao said hurriedly: "Dr. Li, Roche wants to acquire it and said that the price given will definitely satisfy you."

Mi Gao shrugged and said: "Lieder Hoffman came to visit me and my father. The Hoffman family is one of the ten richest families in the world. Roche has controlled the vitamin dynasty for half a century. And Diazepam, It’s been selling like crazy in the West. In addition, Roche is also unique in the field of viruses. After learning that Datang Medicine had developed a drug to combat influenza viruses and cooperated with Glaxo, he was very interested.”

Li Yuandao: "What does his interest have to do with me? We can't cooperate. The pharmaceutical company is not for sale. I'm very busy with experiments here, so don't disturb me if nothing important happens."

Of course he knew who Luo Che was. How could a medical student not have heard of Luo Che?
The crown of global medicine is not worn by the United States, but by Switzerland.

In a land less than half the size of Sichuan and Chongqing, there are two of the world's top pharmaceutical giants, Novartis and Roche.

This comes second. The key is that oseltamivir, which is also a specific influenza drug, Tamiflu, should have been born from Roche...

"By the way, Awen, has the US Food and Drug Administration taken care of it?"

Before entering the laboratory, Li Yuan asked.

An Wenchao shook his head and said: "It's much more difficult there. Glaxo's opinion is to either increase investment again, or wait until Europe opens up before entering the United States, otherwise the price will be too high."

Li Yuan frowned and said: "Glaxo is a little ignorant. They want to increase the share ratio again. It is indeed Big Mac's stinky problem. Tell them that if they are really in trouble, Roche will be happy to help me solve it." This question. Glaxo should only be responsible for sales in Europe, leaving North America to Roche."

An Wenchao's eyes lit up and he said with a smile: "Dr. Li, this is a good idea, why not do this?"

Li Yuan shook his head and said: "The fact that our drugs can pass European drug supervision is not only due to the credit of Glaxo Company, but also the face of the Lancaster family and the Comolli family. What has been agreed upon cannot be ignored by them. .”

Michael reminded: "Li, favors are favors, and business is business. These two families have shares in Glaxo Company, and they will also benefit if they help you come forward."

Li Yuan shook his head and said: "No, don't make it difficult for Margaret and Catherine."

An Wenchao tried to persuade: "Dr. Li, I know you are very loyal, but Glaxo Company may not be like this. Otherwise, they would not put pressure on us in this way to try to improve our performance." Divide. This is not the first time! Their people are very arrogant!"

Michael also said again: "The reason why the Hoffman family has been able to thrive for so long, being rigid but sincere is their family's winning weapon. Li, you really should try to communicate with their family. Luo's current situation is not Not too good. The current president, Adolf Zahn, is a... shrewd and arrogant guy. He once achieved great achievements, but with continued success, he became more and more rude and offended many people.

Now the United Kingdom, Germany, Sweden, Australia, South Africa and other countries are investigating Roche's excess profits. They believe that the price of Valium is too high and it has created a monopoly trade in vitamins. After many years of lawsuits, Roche is already in turmoil.

So the Hoffman family had to come forward in person. This was a good opportunity to make an offer, and also a good opportunity to extend friendship.Lee, I'm not going to lie to you.

You have been very interesting to Glaxo and gave up huge benefits, but they are still not satisfied. No one will say that it is your fault. "

Li Yuan thought for a while and said: "Needless to say oseltamivir... In this way, I have developed the next drug, which is also an antiviral drug. It has special effects on the herpes simplex virus and can be cooperated with Roche. Glaxo The company...well, I originally had my heart set on the bright moon."

Michael didn't know much about medicine, so he didn't react much.

But An Wenchao's eyes widened and he shouted excitedly: "Dr. Li, are you kidding me?! Is this really a special medicine for the herpes simplex virus?! Do you know how many people in the West are suffering from the herpes virus!!"

Mi Gao heard something and his eyes widened. He looked at Li Yuan and said, "Could it be..." He pointed at his dick and shook his fingers.

Li Yuan was speechless, but he nodded and said: "It is indeed the first choice medicine for the second penis herpes virus. In addition, not only the second penis, but also people's mouth, face, hands and other parts will grow. People want to avoid this in their lives. The possibility of contracting the virus is very slim, but most people have no symptoms, and their own immunity is enough to suppress the onset of the virus. However, a considerable number of people will still develop symptoms. Once symptoms occur and an immune response occurs, they will carry them for life. Although the medicine I invented It is a special drug, but it can only eliminate the symptoms but cannot cure it. In other words, it will recur."

This also means an extremely vast market!
An Wenchao's eyes were a bit straight and he said: "In the United States, there are more HSV patients than sardines. Countless people suffer from this virus. As long as it is really effective, it will definitely be very popular! Dr. Li, I'm going now Find Mr. Hoffman!"

After he ran away, Li Yuan saw Mi Gao looking at Li Yuan strangely.

Li Yuan knew at a glance that his grandson was not holding back anything good, and cursed: "Get out of here, it's not because I got it! I have always lived a simple life and kept myself safe, how could I be infected with this disease?"

Mi Gao let out a weird laugh, and when he saw Li Yuan raising his foot to kick him, he turned around and ran away, shouting as he ran: "Li, Jesus' teeth are going to fall out because of your laughter!"

Li Yuan gestured with his middle finger and returned to the laboratory.

There is a reason for being so tolerant to Glaxo. The second type of drug he "invented" was acyclovir, a specific drug for treating herpes viruses.

This miracle drug was originally invented by Glaxo Company and brought huge benefits to Glaxo Company...

When these two drugs are launched and cause a sensation, Datang Medicine in Hong Kong will almost become famous in the world of medicine.

It will take at least six years for acyclovir to be launched on the market, which will be enough to ensure Datang's continuous cash flow...

……

In the afternoon of that day, Li Yuan met Lieder Hoffmann from the Swedish Hoffmann family at the Peninsula Hotel.

A middle-aged man who looks very clean and fresh, not as greasy as Mi Gao at all...

Wearing gold-rimmed glasses, a shirt, casual pants, and a well-groomed beard.

"I spent an afternoon collecting all kinds of amazing information about you, but I never thought, Dr. Li, that you would be so young and so handsome. Wow, no wonder Catherine and Margaret like you so much. If I were a woman, I don’t think I would be able to refuse such a good man.”

Lid shook hands and smiled.

Li Yuan blamed Michael: "Didn't you say that the people in the Hoffman family are very stereotyped? Why is Mr. Lid so funny?"

Mi Gao: "..."

After the four people sat down, An Wenchao said to Li Yuan: "Mr. Li De is very interested in the antiviral drug you mentioned!"

Li De said: "Actually, as far as I know, more than a hundred pharmaceutical companies are currently developing this drug, including Roche, Glaxo, Pfizer and other pharmaceutical companies. Li, I am not doubting you, but you Are you sure you really succeeded?"

Li Yuandao: "I don't have enough time, and I don't have such a good sense of humor as Mr. Lid, so I won't joke about this kind of thing. The pharmaceutical compound has been designed and synthesized successfully, which is enough for you to conduct laboratory tests. If Roche If you are willing to cooperate, then you can dispatch a team of researchers and you will conduct the test. After success, my team and I will complete the development of the industrial process on Hong Kong Island. After that, a series of operations will include marketing, promotion, etc. , can all be operated by Roche.

Of course I know that this is the best way to make a name for a pharmaceutical company, and it will also have a huge boosting effect on the company's stock price.But I am willing to give in, and there is only one request: don't let me come forward, because I still have to move forward in the laboratory. "

Lieder Hoffman was surprised: "Li, if...I'm not doubting you, I'm just saying this. If the medicine you invented is really effective, then you will receive countless honors. Why would you refuse?"

Li Yuan sighed, looked out the window with a sad face, and said: "Lid, you are lucky, Sweden is such a developed and rich country. Your compatriots can freely bathe in the spring afternoon sunshine and taste the afternoon sun. Tea. But my compatriots, hundreds of millions of them, are still in extreme poverty and pain. They take very poor and very poor medicines. Even so, most people cannot afford it. So, I must work hard to develop more useful drugs to accumulate wealth, and exchange their mature drug production processes with developed pharmaceutical companies. I have no time to enjoy personal glory."

Lieder Hoffman said with emotion: "So, this is the reason why you want Roche's process research and development team to come to Hong Kong Island, right?"

Li Yuan nodded and said, "That's right."

Li De stood up, held Li Yuan's hand, and said, "Li, you are a great doctor. Your kindness makes this world a better place!"

Li Yuan said humbly: "You are exaggerating. I just did something I should do, and it was so insignificant."

Lieder Hoffman thought for a while and then said: "Li, if the drug you developed can really treat herpes simplex virus, then in addition to this cooperation, Roche is willing to form a partnership with your Datang Medicine .”

This means that Datang Medicine can win the right to copy Roche's patented drugs after they expire, and share the rights to copy some of the patented drugs after they expire. Although it has not obtained the right to copy, Roche has spontaneously conquered the production process to manufacture drugs, such as first-generation cephalosporins.

These are the most attractive to Li Yuan.

Even though Glaxo had determined the efficacy of oseltamivir, it did not give him such rights.

Li Yuan squeezed Lieder Hoffman's hand and said, "Thank you."

Li De suddenly felt that this "thank you" was particularly sincere.

Of course I am sincere. If the first-generation cephalosporins of the original research drug, such as cephalexin itself, are quite nephrotoxic and are far inferior to the second-generation cephalosporins, let alone the third-generation cephalosporins which have almost no nephrotoxicity, then the cephalosporins currently produced in China... I think There are too many. At present, cephalosporins cannot be produced in China at all.

It would take another ten years to do so, but the side effects of the counterfeit cephalosporins produced at that time were unimaginable.

Not to mention liver toxicity and kidney toxicity, tens of thousands of children are deafened every year.

A few years later, among the performers of "Thousand-Hand Guanyin" that became popular all over the world, 21 out of [-] deaf-mute people were all caused by drug toxicity.

What Li Yuan did cannot change the general trend of history, because most of the medicines used by real big shots at home are imported special medicines.

However, he can still change the fate of countless ordinary people.

that's enough……

Roche acted quickly. Just one week later, it sent an expert team to Longhu Pharmaceutical Factory.

It took a month to repeatedly confirm that in addition to recruiting herpes virus patients on Hong Kong Island, a batch of drugs was specially brought to the research and development base in the United States for laboratory testing.

In the 70s and [-]s in the United States, the prevalence of hippies caused sexual diseases to become rampant.

Herpes simplex virus is one of the main pathogens.Two months later, Catherine, Margaret and her mother, Ms. Lorena, accompanied a team of Roche pharmaceutical technology researchers to Hong Kong Island.

……

"Mr. Gobert, welcome!"

At Kai Tak Airport, Li Yuan shook hands with a middle-aged foreigner who was still meticulously wearing a suit even in the summer and smiled.

Fritz Goebel, one of Roche’s vice presidents.

The current president Adolf Zahn is almost gone, and Fritz Gobert is one of the most promising successors by the board of directors.

Fritz Goebel exclaimed: "Lee, you are so incredibly young and such a genius."

Li Yuan smiled and said: "I am also grateful to Luo Shi for his generosity."

This time, Roche also brought the production technology of the penicillin drug ampicillin and the cephalosporin drug cephalexin.

Although the drugs have similar efficacy, cephalexin is much more potent.

When ampicillin is resistant or you are allergic to penicillin, cephalexin can be chosen.

Luo Linna, director of Glaxo Company, said in a strange tone: "Fritz, Roche is really good at finding opportunities. Datang is Glaxo's partner!"

Fritz nodded happily and said, "It's ours now."

Luo Linna was furious, looked at Li Yuan and said, "Li, why are you doing this to us?"

Li Yuan shook his head and said: "Not to you, but to Glaxo. Glaxo was the first partner I selected, and I thought we would have a happy cooperation. However, Glaxo has repeatedly used various reasons to threaten to increase the share. Now, Glaxo's share of the share has exceeded [-]%, and it is still putting pressure on it. Lorena, if Glaxo continues to break promises like this, Datang will change its partners. I think Roche will be responsible for any lawsuits caused by this. Interested in coming forward to help me solve this problem.”

Fritz laughed and said: "Two elephants fighting is the best marketing promotion in itself. Lorena, do you want to give it a try?"

Lorena yelled angrily: "Swiss, get out of here!"

Li Yuan said to An Wenchao: "Take Mr. Fritz to the hotel."

Fritz said hurriedly: "Is it okay to go to the pharmaceutical factory for a visit first?"

Li Yuan smiled and said: "Of course." After speaking, he shook hands with every process engineer.

After Luo's people left, Li Yuancai hugged Catherine and Margaret respectively.

Catherine looked at Li Yuan with joy and said, "Li, congratulations to you. Oseltamivir hasn't even been launched yet, but you have already made new results. You have worked too hard. Have you been living in the laboratory?" ?”

Li Yuan was surprised and said: "Catherine, how did you know? Did anyone around me inform you?"

Catherine was grinning from ear to ear, but Margaret might be a little shrewder and asked more tactfully: "Li, how many children do you have now?"

Li Yuan squinted: "Nine, what's wrong?"

Margaret laughed and said, "Did you make love with your wife in the laboratory?"

Catherine smiled and scolded: "Mary~"

Li Yuan said thoughtfully: "I underestimate you, Mary, but you still know how to play."

Margaret was "shocked and angry": "It's not me!"

Luolina said disgustedly: "Get in the car and go to the hotel first!"

In the midst of all kinds of eyes, Li Yuan took the three foreign women into his RV.

"Li, you are so mean. Why didn't you tell me about the new medicine? The problems you mentioned are not problems!"

After getting in the car, Luo Linna couldn't wait to ask the question.

Li Yuan smiled lightly and said: "Luolina, Datang wants to cooperate with Glaxo, not become a vassal of Glaxo." He looked back at Luolina and added: "Me too."

Feeling the slight sense of oppression, Luolina held on for a few seconds before she gave up and said, "Damn it, I wish I were a few years younger."

Li Yuan was curious: "Why?"

Lorena said confidently: "When I spread my legs, no man can walk out straight. Why should Fritz compete with me?"

After Catherine and Margaret made accusations for a while, Lorena said happily: "Okay, okay, let's not talk about it. But Li, your behavior really made the company's senior management angry."

Li Yuan said with a smile: "The senior management of Glaxo, are you going to make me angry?"

Lorena sighed: "Did you know? Glaxo's R&D team is only half a step behind you. In the third week after Roche helped you apply for a compound patent, Glaxo also produced this pharmaceutical compound. You Do you know how much the company has invested in this? Tens of millions of dollars! And the reason why it is half a step slower is because the company has increased its resource investment in oseltamivir. I don’t even know if this is a good thing or not. bad thing."

Li Yuandao: "Of course it's a good thing. The number of people in need of oseltamivir is by no means smaller than that of acyclovir."

Lorena frowned and said: "But the production line of oseltamivir is not in the UK, but in Hong Kong Island. We don't even have the initiative."

Li Yuan said with a smile: "That's because some raw materials originate in China and are produced on Hong Kong Island, which can greatly reduce costs." Having production capacity on Hong Kong Island ensures that Glaxo does not dare to go too far in financial settlements.

Li Yuan reminded again: "Luolina, Roche is already a partner company of Datang. We have begun to share some of Roche's generic drug production rights. In this regard, Glaxo Company has not reflected your sincerity."

Luolina smiled bitterly and said: "There is really no way to do this. Glaxo is different from Roche. Although the Hoffman family's shareholding in Roche is not high, Roche has a dual-class share structure, which ensures that the Hoffman family's shareholding in Roche is They have the right to speak, and their family can make decisions on many things. The Comolley family is far from having such a status in Glaxo, I'm sorry."

Li Yuan shrugged and said: "Of course I don't blame you. The Hoffman family gave you a surprise, but Glaxo followed normal company logic. How could I offend normal business logic? But, in that case, Glaxo also There’s no reason to accuse me of anything immoral, right?”

Luolina looked at the young man next to her again and said, "Li, you are really getting stronger and stronger."

Li Yuan smiled and said: "I'm just safeguarding my own legitimate interests... Let's go, I'll take you to the hotel, I'm going to take Catherine and Margaret home."

Luo Linna: "..."

Catherine was very happy and said: "Betty said that your little daughter Xiaojiu is an angel who has landed on earth. I really can't wait."

Margaret reminded: "Betty also said that Ninth Sister's mother is the Battle Angel Archangel, a very powerful woman."

Catherine didn't care: "I came to see Jiu Mei, not to fight for her. By the way, I also want to see Xiao Qi."

Luo Linna looked at Li Yuan meaningfully and said, "Li, you are really good at it."

Li Yuan: "..."

After sending Lorena to the Peninsula Hotel and witnessing her furiously convening a meeting with Glaxo people, Li Yuan really took Catherine and Margaret back to Tsing Yi Island Manor...

……

Forty-nine cities, flower hall.

Seeing Qin Daxue and two staff members carrying a basket of watermelons in, Mr. Cao stood up and stepped forward to look at it and said with a smile, "Did you get results? Oh, look at how thin you are!"

Qin Daxue has lost a lot of weight, but her eyes seem to be brighter than before. She smiled brightly and said: "It's better to lose weight and be more energetic! Mr. Cao, this is a watermelon grown in the greenhouse, brought to you Taste it.”

Mr. Cao said unhappily: "It's not the season to eat watermelon yet. It's so expensive. What should you give me? I thought it was a basket of vegetables."

Qin Daxue chuckled and said: "It's really not the first batch. The first batch was sold to foreigners in Forty-Nine City. They have money and are willing to spend money. Mr. Cao, I didn't expect that this batch of watermelons , It helped a lot. Half of the debt for the greenhouse was repaid, and the remaining half was almost done with the continuous harvest of fennel. After autumn, half of it was planted with fennel and half with vegetables. This year, there will be big profits! Isn’t that right? Is it a happy event? I’ll send you some watermelons to tell you the good news.”

Mr. Cao said happily: "Okay, okay! I knew you were capable, and you really got results. Sit down and have a rest."

After Qin Daxue helped Mr. Cao sit down, he said, "Mr. Cao, my movements were too big, and I have troubled you."

It is far from being fully open at the moment. Her extensive economic development in the suburbs of Beijing and her various methods are astonishing, which has really attracted a lot of criticism.

If Mr. Cao hadn't used Prime Minister Yu Wei to protect him, Qin Daxue would have been dismissed from office again even if he didn't go in for tea.

Struggle is still the theme of the moment...

Mr. Cao patted her hand and said with a smile: "Don't be afraid or worry about anything. As long as you do the right thing and serve the people wholeheartedly, it doesn't matter. Your district still uses the production brigade as the basic unit and it is still a collective system. Well. There are still people who criticize you, saying that you are a little girl and your methods are too cruel. You instruct the public case unit to hit the people who commit crimes in the district too hard and use too heavy blows. What do you call this? You can't do it just because you are against those people. If you raise the flag, you can do whatever you want. What is the difference between that and some people in the past ten years? Daxue, don’t worry, just let go. When Gu Gu came to see me yesterday, he specifically mentioned you. He spoke very highly of you. Gao, you are said to be a woman, no less than a man, with a heroic spirit!"

……

(End of this chapter)