godfather of surgery

After receiving Lan Xueping in the inpatient department, Yang Ping ordered the doctor in charge to seize the time to complete the patient's examination. Only with detailed examination information can the subsequent surgical plan be determined.

This new method has not been used by Yang Ping in reality, so Yang Ping plans to invite Professor Deng to formulate a surgical plan together after completing the examination.

Before retiring, Professor Deng worked at Tiantan Hospital in the Imperial Capital, which has the best neurosurgery in the country. For this type of new surgery, it is a sign of respect to discuss this type of new surgery with the old professor, and he can also listen to the old professor's opinions and brainstorm.

Fang Liu hired a female nurse to take care of Lan Xueping. Fang Liu was very attentive. He explained Lan Xueping's living habits and precautions in care to the nurse in detail.

After everything was arranged, Fang Liu left. Before leaving, he did not forget to say hello and thank Yang Ping.

Fang Liu and Lan Xueping were neighbors when they were young, and later they were classmates in elementary and middle school. Fang Liu has always been secretly in love with Lan Xueping.

After graduating from high school, Fang Liu went to the army, and Lan Xueping was admitted to the Normal University. Although the two were separated, Fang Liu had been silently paying attention to his crush. Later, when he learned that Lan Xueping was ill, Fang Liu immediately stayed up all night Unable to sleep, Fang Liu was already a firefighter at that time.

The next day, Fang Liu contacted Lankoping and desperately bought a plane ticket to rush to Lankoping's city. When he saw Lankoping sitting alone in a wheelchair and living in a dark and narrow rental house, he felt very painful. The beloved woman was actually in such a situation, Fang Liu immediately decided to take Lan Xueping to his city and take care of her for the rest of his life.

Lan Xueping knew that her condition was incurable. She had been seeking medical treatment while working, but various treatments were of no use and her condition was getting worse.

She knew that sooner or later, she would be paralyzed in bed and become a burden. She could not drag Fang Liu down in his prime.

Lan Xueping is also a quiet and motivated girl. After graduating from a normal university, she worked as a teacher in a training institution to teach English. Later, she fell ill and had to resign at home. However, in order to support herself, she worked part-time as an English translator online because her English skills were very good. High, so you can earn thousands of dollars on average a month to survive.

Her mother passed away relatively early, and her father also died of penguin disease a few years ago, so she was alone and helpless.

But Fang Liu didn't care about this at all. She packed her things in her simple rental and pushed her in a wheelchair to leave. Lan Xueping burst into tears: "You will regret it."

"I don't regret it. I regret not coming to pick you up sooner."

Without saying anything, Fang Liu contacted the landlord to check out, then took his luggage and pushed Lankoping back to the city where he worked and lived.

This care lasted for three years, and Fang Liu never regretted it. For three years, he took good care of Lan Xueping every day.

Due to the nature of his work, Fang Liu's working pattern is three shifts, with 24-hour shifts and two days of work.

On the day he was on duty, he made breakfast in the morning and had breakfast with Lankoping before going to work. He would prepare pastries and milk for Lankoping at noon and evening. He would put the pastries, milk and water within Lankoping's reach. When he came back the next day, he would make hot dishes and rice for Lankoping.

During his rest time, Fang Liu also sent Lankoping to the hospital for acupuncture and massage rehabilitation. Although these could not solve the fundamental problem, they could delay the progression of the disease to some extent.

In the past three years, apart from going to work, Fang Liu has spent all the time with Lankoping, pushing her to walk in the park, watch movies and eat snacks.

In order to better take care of Lankoping, Fang Liu is now ready to resign. He bought a cheap second-hand car and decided to take Lankoping around the country with his savings for many years. He wants to make her happy every day. Happy.

He has submitted his resignation application and will leave the fire brigade after one more month of service.

In the doctor's office, only the doctor on duty and his intern were busy writing medical records. The other doctors were still busy with operations and had not returned.

Yang Ping found a computer and pulled up Lankoping's MRI film to continue his research.

The arachnoid membrane of the cerebellomedullary cistern is removed, the arachnoid membrane of the cerebellum and brainstem is released, the dura mater is relaxed, the posterior cranial fossa craniectomy is performed, and the bilateral occipital muscle flaps with occipital arteries are applied on the cerebellar surface to achieve decompression of the cerebellar brainstem. With the dual function of increasing blood supply, Yang Ping mentally planned the operation.

Nurse Cai's ankle has no signs of recovery yet, but she cannot sit still during her daily work. For example, she has to participate in the afternoon nurse rounds.

How to do?

Xia Shu could only push her in a wheelchair, so the scene of the nurse's ward rounds in the afternoon was strange. A grown man pushed the head nurse and took a dozen nurses to the ward rounds.

Yang Ping observed Xia Shu's expression from a distance, and he didn't seem to be reluctant. He seemed to be more accepting of the job.

Nie Shun'e was preparing to be discharged from the hospital and bought fruit baskets for the doctors and nurses. They also bought one for Yang Ping. The couple thanked Yang Ping in person and bowed respectfully. It was so polite.

They planned to open a business on the overpass of Sanbo Hospital after being discharged from the hospital, so they decided to rent a house first and move here after the house was completed.

Pan Doudou was quickly transferred out of the ICU, and the operation was very smooth. Director Fang carried two boxes of cherries to the surgical institute. He also walked around the department to see if there was anyone who needed help, and he obviously regarded himself as a non-staff member.

When Director Fang saw Xia Shu pushing the head nurse out, he immediately stepped forward and volunteered: "Dr. Xia, take a break and I'll do the pushing."

At this time, all the nurses' eyes were focused on Director Fang. This was not a gaze, it was clearly an arrow. It felt like they were going to eat him. What's going on? Do good deeds and still be hated? Is the social atmosphere so bad now?

Director Fang subconsciously took a few steps back, not knowing where he went wrong. He could only stand in the corridor and think about life.

Yang Ping went back to the doctor's office to rest for a while and entered the system space laboratory. The system space was very efficient. The electron microscope photos of dead tumor cells had been completed. There was no way to process the billions of pictures manually.

Fortunately, the system's panel is equivalent to a supercomputer. Although the computing power is far less than the computer that the system promises to reward in the future, it is at least enough for now.

Yang Ping left the comparison and analysis of the pictures to the system panel, and began to pay attention to the newly developed muscles.

Under the guidance of spatial guidance genes, what can be cultured from stem cells is no longer a bunch of scattered cells, but a complete muscle. And as other parameters become clearer and clearer, the success rate of cultivation is getting higher and higher, and the success rate is now stable at more than 80%.

After finding the first spatial guidance gene, Yang Ping turned his attention to the next spatial guidance gene. He planned to look for the spatial guidance gene of cartilage, because compared with complex organs such as the heart, Yang Ping believed that the formation of muscles and cartilage The control must be very simple and simple.

Complex organs such as the heart may have more than one guidance gene, and the regulatory mechanisms between them must be very complex.

Start simple and go step by step.
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At this time, a large laboratory of a company in the United States, which is the world's top stem cell laboratory.

The spacious laboratory displays various top-notch experimental equipment, such as biological 3D printers, which are top-notch products worth over million yuan. These products are their core technologies and they refuse to export them like their competitors.

Dozens of incubators with transparent windows are placed in the laboratory, and now only the last one is left unopened. Dr. Conor hopes for a miracle.

As the transparent glass cover opened, Dr. Connell put on gloves and carefully took out the incubator inside. Unfortunately, there was no miracle and it failed again. He couldn't help but shake his head in disappointment.

None of the forty incubators succeeded, and the entire army was destroyed.

He had already predicted this result, because at this point in the experiment, he was already very confused. Without a breakthrough in basic research, it was no longer possible to move forward, and the way forward had been locked ruthlessly.

However, the company has great expectations for this technology. It is said that the greater the expectations, the greater the disappointment.

But the reality is this. No matter how stem cell technology develops, what will be cultured in the end will be cells, not organs, a pile of scattered cells instead of formed organs, and a pile of bricks instead of a house.

This new technology created by Dr. Cornell uses scaffolds to guide cells to crawl. In fact, it is not much different from biological 3D printing. They both use foreign scaffolds to passively accumulate cells.

At present, there has been no breakthrough in scaffold crawling technology, and bio-3D printing is not much better and is still lingering in the same place.

The printed reduced and simplified version of the "organ" can only be used for some experiments such as drug research, and cannot be used clinically for the time being, because it is not a real organ. Strictly speaking, it is just an "organ" made of cells stacked according to the shape of the organ. Does not have the microstructure of an organ.

Fortunately for Dr. Conor, although the progress of the experiment is very slow, their stem cell technology is still the most advanced in the world, at least ten years ahead of others.

The company has bet too much on this and lists stem cell technology as one of the major strategic technologies that will occupy the commanding heights of biotechnology in the future.

Dr. Conor's glasses were fogged up. He took them off and rested against the wall next to him, looking very depressed.

Seeing this, the assistant said to the side: "Should we change our thinking? Recently, a Chinese doctor published several articles, mentioning a series of new concepts such as space-guided genes and fine anatomy. If we can really figure out the space of organs, Will guidance genes and fine anatomy be of great help to experiments?"

Dr. Cornell shook his head. Why hadn’t he studied those papers?

"The spatial guidance gene is just a hypothesis. No experiments have been able to verify it so far. It can be said to be too advanced a hypothesis and will not be of any help to current research." "If we take this path, we will need to face a huge amount of data. .”

"First we need to decode the genes of stem cells, and then we need to find ways to identify these genes. This kind of project is larger than atomic bomb research and moon landing, and the cost of trial and error is immeasurable. Moreover, this is just a hypothesis. Since it is a hypothesis , it is very likely that you will invest huge human and financial resources and end up with nothing.”

"The most important thing you should not forget is that if you are very lucky and all of what you have just mentioned is successful, this is just the beginning, and there will be more and greater difficulties later."

''Think about it, is it possible to give up more than 20 years of hard work and start everything from scratch? "

''Do you say that Boeing will abandon all existing engine technology, change its route, and invest fully in researching the so-called curvature engine? "

The assistant understood that it was true that if a hypothesis was too advanced, it would be difficult to confirm.

Moreover, the laboratory now has more than ten years of accumulation and is still the world's advanced technology. How could it be given up?

If we don’t give up here, even if we invest in research on space-oriented genes and fine anatomy, it’s just a multi-lateral bet to occupy the track.

"What about microanatomy? I think it's very practical! With the corresponding bio-3D printing technology, it will be a good route to use bio-3D printing technology to achieve true replication of organs." The assistant is obviously a fan of Yang Ping , admiring the technology mentioned in Yang Ping's paper.

Dr. Conor still shook his head:

"Similarly, it seems possible to realize it, but in fact it is still too difficult, the threshold is very high, and it is not practical, because to truly understand the fine anatomy, we must re-establish a digital human based on the fine anatomy, which requires the study of digital Medical researchers are working with us."

"But you don't know that before you can create a digital human with fine anatomy, you have to do an extremely difficult job, which is to use a huge number of corpses to make slices, and then use an electron microscope to conduct comprehensive analysis of the cells of each organ of the living person. Oriental photography, use these tasks to collect raw data, and then hand over the raw data to supercomputers for processing and modeling. The early data collection is not only massive, but also unachievable. Where can you find volunteers to dissect each item for you? A site and then use an electron microscope to take pictures of the cells?”

The assistant was suddenly enlightened again. Perhaps because of his admiration, he did not study the technical details.

But Dr. Conor is different. He has done the most careful research on every detail of the technology.

"Mr. Conor, you don't have to be upset. In fact, in terms of regenerative medicine, we are already ahead. No one can catch up with us. The entire core technology is in our hands. As long as we impose a technological blockade on the whole world, the achievements we have established over the years will Technical barriers will only get higher and higher. Even if we hand over these laboratory data to them, they will not be able to understand it at all, let alone surpass us." The assistant comforted Dr. Cornell.

Regenerative medicine, anti-tumor and their derivative technologies are the core technologies of the future biomedical industry. Whoever masters these technologies will be able to control the future medical industry, which is why Dr. Cornell spares no effort.

"Well, I'm not upset, but confused. How should we go next?"

Dr. Conall was indeed confused.