godfather of surgery

Chapter 613 Inducing Substances
Imperial Union Hospital.

Professor Liang was sitting on an office chair, with the removed glasses placed on the front desk, and he was listening to Professor Hu Guolin's report on the arrangement of the phase II clinical trial of the spinal external fixator.

"Very good. If necessary, please invite Yang Ping to demonstrate the operation. After all, it is a new technology. We are only grasping it theoretically. It would be better to observe a few operations. In addition, 301 has already taken action and gave Yang Ping 10 beds. With a supporting team, we regularly invite Yang Ping to 301 for surgery. This kind of cooperation is feasible and we can follow suit. In terms of case resources, especially special cases, we have more than 301. Let’s also give Yang Ping 10 beds. A team will assist him, and this team will have Song Yun as the team leader, and select a few doctors at the attending level, so young people will feel more comfortable working together."

Professor Liang leaned back in the chair, narrowed his eyes slightly, and pinched the bridge of his nose.

Professor Hu Guolin suggested at the side: "301 has 10 beds, can we increase the number of beds, preferably doubled? It is much easier for us to increase the number of beds than them."

Professor Liang slowly shook his head and said: "Don't increase, don't engage in this kind of malicious competition. In the end, the tide will rise and all boats will be embarrassing. Invite Yang Ping into Xiehe through cooperation. Our purpose is the same as that of 301, to care for talents. Respect talents, I have to admit that this young man is a rare genius, at least among the young people I have met, no one can compare with him, you see, the data of this external spinal fixator was so beautiful at that time, I once I thought the data was flawed, but after verifying it myself, I found out that there is no problem. It is really unexpected to come up with this new technology in just a few months.”

"I heard that there will be further actions from 301. It seems that they are not as simple as cooperation." Professor Hu Guolin was a little worried.

Professor Liang smiled and said: "Don't worry, if Yang Ping changes places, it's better to come to our place than to go to 301. Our place is more suitable for him, but I have thought about it for a long time, and it is not the best to come to our place or go to 301." Things will limit his development. I'm still thinking about what is the best way to get him into the health care team. I have met Qin Shi and Liu Xingguo and mentioned this matter. They will handle it. "

"I also stayed in Sanbo Hospital for a while, and I still know a little about Yang Ping. This young man usually doesn't have much to say, and he always looks very deep. He doesn't usually attend any meetings in the hospital. The assistant, anyway, he only cares about his own patients and conditions, and seems to have no interest in other things, and he feels that it is difficult for others to get along with him." Hu Guolin concluded.

Professor Liang disagreed with Professor Hu's words: "Genius, who has no personality, is a genius because he is different, and is not a genius just like everyone else. It is very good that Sanbo Hospital has this, that is tolerance, we It can’t be that inclusive.”

"I agree with that. The dean of Sanbo Hospital is also a very individual person. He and Han Jiangong gave Yang Ping the entire surgical authority. You said that a young doctor has only worked for a few years and has not passed other specialties. Training, put it in other hospitals, it is impossible to give him so many surgical authorizations, what if he dies?" Professor Hu Guolin has never been able to understand why Sanbo Hospital is so bold.

At that time, a scoliosis correction operation was complicated by cardiopulmonary deformity adhesion, so Yang Ping was asked to perform cardiopulmonary surgery at the same time as spinal correction.

This kind of interdisciplinary surgery is absolutely impossible to happen in other hospitals. If anyone proposes such an idea, it will definitely be regarded as a joke.

"That's why he stayed in Sanbo. To be honest, I was obsessed with bringing him in before, but I gave up on it later. As long as he stays in China without going abroad, I'm satisfied. On the one hand, I can protect him. Outside of my field, can I protect him? Mu Xiuyu Lin Feng will destroy him. His personality is suitable for academics, but it is easy to offend people. In Sanbo, there are Xia Changjiang is protecting him, so this kid can make a name for himself, and if we put it here, the foundation alone will not be able to manage it. So much money will be directed to him to do scientific research alone. Can everyone agree? Can the above agree? The hospital leadership level Who dares to push forward this kind of thing like Xia Changjiang, if something goes wrong, Xia Changjiang will not be able to afford it." Professor Liang praised Dean Xia quite a lot.

"Well, that's true. The foundation was established at the time, but Xia Changjiang put in a lot of effort. I heard that he went to the provincial department, the civil affairs department, and the provincial government every day to lobby for signatures from all the big bosses." Professor Hu Guolin knew about this matter.

"This kid has a bright future in the future and can make a big difference. Sanbo Hospital is a hospital directly under the provincial government, but it's a bit weak, and it doesn't match his energy. I'm wondering if it can promote the upgrade of Sanbo Hospital. How to upgrade, I haven't figured it out yet, I have to discuss it with some old leaders." Professor Liang seemed to be thinking deeply.

"What happened to Hans last time almost destroyed the external fixator of the spine. Sanbo Hospital alone can't handle this kind of thing." Hu Guolin still had lingering fears.

Professor Liang's face darkened: "Hmph! Even if a company is a multinational giant, what can it do? Do you know that their behavior is against our entire medical industry? It is already polite not to kick them out. Fortunately, even if they Adjust, and finally surrender, if things escalate again, so what if they are swept out, without this company, the vacant market will be filled immediately.”

"What I mean is, this incident also exposed your old worry. Sanbo Hospital is too thin and does not match Yang Ping's ability. This is just a spinal external fixator. In the future, he will produce more valuable results. If you touch other people's cheese, you will get into trouble, this time you always intervene in time, so you may not be so lucky next time." Professor Hu Guolin said what he was worried about.

Professor Liang nodded: "Yes, so I was thinking, how to upgrade Sanbo, make this platform bigger and stronger, so that he can show his fists."

"Old Liang, there is one more thing?"

Professor Hu was quite embarrassed.

"What's the matter?" Professor Liang asked.

Professor Hu rationalized his thinking and said: "Our hospital proposed to visit the MIT Baitou Bioenergy Research Institute, but was rejected by the other party. Zhang Chunquan said that the current project refuses outside visits, and he has no choice. I heard that they have established an inducible The pluripotent stem cell has made the most breakthrough progress in the mechanism of stem cell regeneration and differentiation rearrangement, and it is a step closer to cloning complete organs. The biggest contribution to this project is actually Zhang Chunquan."

Professor Liang asked slowly: "Has Zhang Chunquan become an American citizen?"

"Yes!" Professor Hu whispered.

Professor Liang remained silent, feeling a twinge of pain in his heart.
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Before the shift, there is still a certain amount of time, and no one will disturb him. Yang Ping conducts experiments in the laboratory of the system space.

He often enters the system space for experiments in the morning, noon, and before going to bed. At this time, the system space is the most stable, and he stays in it for the longest time. Sometimes he also uses the operating room locker room to enter the system for experiments.In short, he used the time he could use.

Yang Ping used the teratoma experimental body purchased from the system mall as the research object to observe how the teratoma grows and develops, observes the teratoma tissue cells at each stage with an electron microscope, and observes how they divide and differentiate step by step, and then uses The electron microscope takes continuous pictures and arranges the pictures in order.

Yang Ping also extracted body fluids and tissues for research on the surrounding environment of teratoma generation, growth and development, to find out whether there is some kind of inducing substance in the surrounding environment, and to find out what induces the human body when pluripotent stem cells differentiate. , How to regulate the induction, whether it is induced by a single method or a combination of multiple methods.

It's a lot of work, but the instantaneous rules of system space make time very cheap.

However, there is a psychological limit to the time spent in the system space. Yang Ping's current psychological limit is getting higher and higher, and the time he stays in it is getting longer and longer.

Every time Yang Ping does experiments, try to stay until the limit time before coming out, and then rest in reality for a while, and then find a quiet time before going in.

The relief period set by the system space is like a man's sage time. After staying in the space for a period of time, he must come out to rest, spend the "sage time", and then go back in next time, and so on.

Having reached the psychological limit, it is meaningless to forcefully extend the time. The already unstable mental state cannot continue the experiment, and this forced extension of time is also a kind of psychological damage.

But in any case, compared to reality, time in system space is quite cheap.

Through this period of research, Yang Ping made some small breakthroughs.

He found that there are some "inducing substances" in the surrounding environment of teratomas. These substances are different around different differentiated tissues of teratomas, while the substances around the same differentiated tissues are the same.

For example, the biochemical substances distributed around the muscle and bone grown from teratoma are different, but they are also muscle tissue. Different experimental subjects have the same "inducing substances" around the muscle tissue of teratoma.

At present, Yang Ping only draws general conclusions from electron microscope observations. Whether they are the same or not still requires structural analysis of these substances.

If it is really the same, at least one question is suggested: there is a group of the same living substances around each differentiated tissue, and whether these substances play an inductive role will be further studied.

Yang Ping also observed a phenomenon that the distribution range of these substances is exactly the same as the distribution range of the corresponding specific tissue cells. If the range is exceeded, these substances will be automatically decomposed and eliminated.

Exactly how to do it, Yang Ping is not clear yet.

Yang Ping deduced that these substances should be the possible "inducing substances".

The next step is to extract these biochemical substances, and then use cryo-electron microscopy for structural analysis.

The structure of biochemical substances is analyzed one by one, and then they are accurately classified, equipped with teratoma differentiated tissues, and a paired "induced mass spectrum" is produced.

Then, according to the "inducing substance spectrum", some "inducing substances" are extracted from the experimental body to cultivate pluripotent stem cells. If the differentiation of pluripotent stem cells can proceed in the expected direction, then these biochemical substances can be identified as inducing substances.

If the target cells cannot be differentiated, it means that in addition to the inducing substance, there are other inducing ways to cooperate with the inducing differentiation, or these are not inducing substances at all.

This kind of work is extremely boring and cumbersome, and the workload is huge. In the laboratory of the system space, the mechanical assistant can only help with some unskilled work, that is, replace Yang Ping's hand, and cannot replace the work of Yang Ping's brain, so a lot of The work needs to be done by Yang Ping himself.

And sometimes the initial research direction is considered to be correct. When the research reaches a certain level, it is found that the overall direction is wrong.

Therefore, sometimes a scientist only gets a little breakthrough after decades of research, and some have not made a breakthrough in their entire lives.

In addition to inspiration, diligence, and an accurate grasp of the research direction, doing scientific research also has an element of luck. Of course, the element of luck is premised on diligence. Without persistence for more than ten or decades, any luck is in vain.

Just like there are tens of thousands of paths to the goal, only one is correct, and no one has more information to judge which path is correct when we set out. Wrong way, some people find out that they are wrong after walking this way, but no matter what, you have to go on it to have a chance of success.

Such basic research is very difficult to produce results, and the research is not profitable. Therefore, scientists are required to calm down and do research in a down-to-earth manner. At the same time, they are required to provide stable and good treatment for scientific talents in basic research. Get on with it.

And basic research is the most important part of the entire scientific research system, just like the cornerstone of a building, without the support of basic research, no matter how prosperous the applied research is, it is like building tall buildings on the beach.

Yang Ping recorded his stage research results and left the system laboratory.

He went through the emails in his mailbox.

August will report the Little Duke’s condition by email every day. His vital signs are stable and he has not found any neurological symptoms for the time being. After the postoperative magnetic resonance examination, there is no local signal change in the spinal cord, indicating that there is no embolism in the spinal cord blood vessels. The negative pressure drainage tube of the patient has been removed, the vicious cycle of the cardiovascular system has been corrected, the heart is improving, and the amount of blood circulation shared by ECMO has gradually begun to be reduced, and we are trying to slowly wean it off.

August sorted out the list of scientific research projects funded by the Duke Fund, and the list has been sent to Yang Ping.

Yang Ping printed it out, ticked a few projects related to his subject, and planned to arrange time to investigate and see how far his colleagues in the world have researched, communicate with each other, learn from each other, and avoid working behind closed doors.

After finishing these tasks, Yang Ping took a rest for a while, waiting for the handover operation.

This is a trilogy of his work, year after year and day after day.

(End of this chapter)