Imagine the world

Chapter 17 Big Fish

Rochard watched Huazhenxing for a long time, and finally sighed: "I didn't want to say too much. I'm afraid you won't understand some things."

Hua Zhenxing said with a stern face: "I can escort you on foot through the wilderness, but that doesn't mean I'm just an ignorant savage."

Rochard: "Okay, I'm going to say goodbye tomorrow, I'll tell you today. This place is backward, stupid, and chaotic, but you know what the most advanced institution is here?"

Hua Zhenxing: "As you are asking this kind of question, the answer is of course International Hospital."

The Port Fiso International Hospital was developed from a refugee tent hospital 15 years ago. It has received funding from many international organizations, and its scale is now quite large.It has thousands of hospital beds, and even forms a relatively independent safe area in the city, which is often overcrowded.

To say it is advanced refers to those facilities that represent its highest level. There are world-class research rooms, operating rooms, laboratories, and intensive care units. The hundreds of high-end wards are not inferior to private hospitals in developed countries.But these conditions are generally not enjoyed by ordinary people. Most of the general wards and beds in the hospital are very poor, and the disposal and observation hall is overcrowded.

Rochard nodded: "Yes, it not only has the most advanced medical equipment and various wards, but also the most advanced laboratories and research departments. It has a large enough scale and enough patients to see to a wide variety of patients, so it has the best conditions for drug trials."

Hua Zhenxing frowned: "You guys are conducting illegal drug tests here?"

Rochard shook his head and said: "It's not us, it's them, I didn't participate. As for whether it's illegal or not, foreign laws can't control Fesuo Port, and the laws of Jili can't control international hospitals, not to mention they seem to be There is no clear law in this regard.

People in power in this country will not interfere in the affairs of the International Hospital, and in exchange for it, the International Hospital will also guarantee their medical safety.

As for drug trials, there are pretty much anything you can think of.At first, many institutions put their laboratories here because it is convenient to do animal experiments. For example, monkeys here are easy to get, and there is no interference from those animal protection organizations... But later, many people realized another convenience. .

Do you know the process of developing a new drug?First do pharmacological and biochemical analysis, then do animal experiments, and finally do clinical trials.The clinical trial is divided into one to four phases, and the cost is very, very high. If the research and development fails, all the investment will be wasted.

And here, the cost is very low.First do a good job of pharmacological and biochemical analysis abroad, and then come here to do the simplest animal experiments, sometimes it depends on your conscience..."

Hearing this, Hua Zhenxing interjected: "Does anyone still skip the animal testing stage and do clinical trials directly?"

Rochard: "Yes, although there are not many such cases, but I have found that a small dose is first tested on individual people, and if there is no serious reaction, then continue. But more cases are that the animal test is not complete, and the data The accumulation and observation period is not enough, so it goes directly to the clinic.

Clinical practice is strictly regulated.For example, in a phase I trial, the volunteers are usually healthy people.The volunteers in the Phase II to Phase IV trials are all patients with corresponding indications, that is, people who suffer from certain diseases take medicines to treat certain diseases.There is also a control group in the second phase of the trial, that is, people with the same disease cannot take this drug, and either take a placebo or other marketed drugs, it is best to only take a placebo..."

Hua Zhenxing: "Just say the main point! I can go back and check the information on all of these."

Rochard: "Drug trials need to sign a responsibility agreement with volunteers to ensure that volunteers are fully informed and adequately compensated. In Feso Harbor International Hospital, there are only patients, no volunteers, they are just data. sample."

Hua Zhenxing gasped: "Those people don't actually know about it? Not only are they not compensated, they are even spending money to do drug tests for others?"

Fesokang International Hospital has a charitable nature, but it is not a public institution in the country. It was first established by an international rescue organization and accepts donations from various organizations around the world.It also charges, and it's expensive, and few people can afford it, except for some simple glitch.

People who don't have money and want to see a doctor can apply for assistance, which requires filling out several forms.There are many illiterate people here, and many do not know foreign languages, so the forms are filled out by hospital staff, corresponding to different charity assistance projects.If you get assistance from a certain project, you can spend no or less money, but after all, some people spend their own money to see a doctor, at least part of the money.

Rochard nodded and said: "In fact, the most important thing is not these. The clinical trials here are not standardized. Sometimes, in order to get complete data in the shortest time and at the lowest cost, even the first to third clinical phases are mixed together. made."

Hua Zhenxing: "How to do this?"

Rochard: "Observation of direct administration, starting from a small dose, some people are given the drug and some are not given it. Those with corresponding symptoms are given this medicine, and those who do not have corresponding symptoms are also given this medicine... Sometimes you can get better results." Comprehensive data is hard to come by even through formal methods."

Hua Zhenxing: "I don't quite understand it."

Rochard: "Let's give an example, such as contraindications and new indications. Usually, the volunteers in drug trials cannot have other underlying diseases, and medicines for digestion cannot be given to people with heart disease. Knowing what the reaction will be, then you can know now, or you can discover that this drug can treat new conditions."

Hua Zhenxing was speechless for a while, and after a long silence he asked, "Are all the doctors in the international hospital involved?"

Rochard quickly shook his head: "No, no, most doctors didn't participate. They came to treat the disease, and their professional ethics didn't allow them to do that, and they didn't even know it."

Hua Zhenxing: "Why didn't you know about it?" Before he knew it, his tone was already interrogating.

Rochard explained: "The situation in international hospitals is also complicated. Doctors from different countries use drugs from various sources around the world, and it is normal that many situations are not understood.

In the most backward part of the world, hospitals often see the latest drugs developed in the most developed regions of the world.Some doctors also know that the sources of many medicines are irregular, but they have no evidence to question them.

In this place, it is good to have medicines to treat diseases. Basically, what medicines are used.Most doctors are still doing normal treatment and taking normal medication according to the instructions.After all, there are only a few people with problems, and even with the drugs in question, most of them can still be cured..."

Having said this, he sighed again: "There are still many doctors who are not even qualified to question, or have no ability to question. For example, doctors from many backward countries, they are just told that there are the latest advanced drugs in the world, It was donated by non-profit organizations through special channels.”

Hua Zhenxing: "There is also a chain of contempt, or a chain of discrimination, within the hospital. For example, doctors from foreign countries look down on local doctors in Jili, and Dr. Luo, you should be at the top of this chain of discrimination, right?"

Rochard didn't answer this question, and Hua Zhenxing asked again, "You found out this inside story in the hospital and collected evidence, so you were hunted down?"

Rochard nodded and said: "Yes, I have collected a lot of first-hand original materials, and I have also preserved some samples, and have mastered the secrets of some people. I don't know that this matter has been exposed, but you called and said Datou Jin was going to kill me, and I knew it at the time."

Hua Zhenxing: "What does this have to do with Jin Datou?"

Rochard: "Drug trials have strict rules, some of which are to protect volunteers, and failure to comply with these rules may lead to faster, lower-cost trials.

But on the other hand, it also has professional requirements, such as how to organize those who do not know to act as volunteers, how to ensure that they are not testing a new drug while testing another new drug, how to follow up and observe... These all need local people help.

This is what Jin Datou does. The Datou Gang organizes physical examinations, sees a doctor on their own territory, and even regularly makes them take drugs that are claimed to have preventive effects. There are special people who do statistical observation. "

Hua Zhenxing suddenly remembered something: "Do you know Shire, the big man who shot his accomplice to cover our escape yesterday. His aunt and two younger sisters fell ill last year, so I asked for your help. The big head gang organized People went to the hospital to be guinea pigs, so why didn't they help send them to the hospital?"

Rochard smiled bitterly: "That's because she is really sick, and it's a deadly infectious disease! The Datou gang members don't know the inside story, only Jin Datou knows that he has money to take it."

Hua Zhenxing: "No wonder Jin Datou wants to kill you, and the person who hired him has to kill you."

There was a hint of ridicule at the corner of Rochard's mouth: "For a mere [-] meters of gold, the big head of gold will be used as a gunman. The interests involved are so great that it can make several miles of countries go bankrupt."

Hua Zhenxing: "You can explain it again."

Rochard: "Actually, it's useless for Jin Datou to know about it. It's not something he can get at all. I'll give you a few small examples. Which group has developed the latest drug, how much does it cost, At what stage of the trial, these data are in the hands of professional people, and they can basically judge whether the new drug can be launched and the efficacy and profit after it is launched.

And knowing this, you will know how the stock price will change, and knowing how the shares will change, you can operate in advance and use leverage to enlarge.This is only one aspect. If these data fall to competitors, the value may be even greater.If some information is made public, it will cause scandals and bring huge losses to those pharmaceutical groups. "

Hua Zhenxing interjected: "Scandal? Scandal of illegal clinical trials?"

Rochard sighed again, shook his head lightly and said, "In Mi Jianguo, not too many people really care about the life and death of Jili people, most people don't even know where Jiliguo is, or even I don't know that there is another country in the world.

But it involves capital interests. If it can find operational flaws to attack, it will be a scandal in the capital market.Do you know how much the market capitalization will change if the stock price of some large groups falls or rises by a few percentage points? "

Hua Zhenxing: "According to this, how many pharmaceutical groups and how many drugs have you obtained illegal test data?"

Rochard: "Documents do not equal evidence. Even if you find out that someone is doing this kind of thing, it is often useless. It is legally difficult to prove that it has anything to do with the people behind the scenes. What I want to have is the complete chain of evidence. , who is leading what project, what are their names, what are their identities, and what experimental data are produced.

Then see which companies have applied these data to the documents required by law, have submitted new drugs for marketing or are in the process of submitting new drugs for marketing.I have evidence of more than a dozen pharmaceutical groups and dozens of drugs, all of which are the largest pharmaceutical groups in the world, some in Mijianguo and some in Luobazhou.

I have electronic backups, but electronic materials are not enough. In some cases, original documents are required. I also got some samples that can be stored at room temperature.The samples and materials are usually locked in the office. Yesterday, the situation was urgent, and I packed the most important things in my backpack. "

Hua Zhenxing: "I can escort you to Miri Airport, but in this situation, you will be safe when you return to Mijianguo?"

Rochard: "It's not that I'm unprepared, and I won't go directly back to Mijian."

Hua Zhenxing: "What are you going to do?"

Rochard avoided answering, raised his head and said, "You want to ask Jin Datou why he wanted to kill me, I have already told you. Now it's your turn to tell me, your training is called Yang Yuan, can you teach me? "

Hua Zhenxing summoned the "system" attentively, and suddenly found that the completion progress of "Task 90.00" had reached more than [-]%. It seems that what Dr. Luo said was basically the truth, but there were still some final situations that had not been clarified.

(End of this chapter)